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Cyclo(Phe-Gly)
Cyclo(Phe-Gly)
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cyclo(Phe-Gly)
Price: $238 / 10mg
CAS No.: 5037-75-2
Catalog No.: CFN90286
Molecular Formula: C11H12N2O2
Molecular Weight: 204.23 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: From Pantoea agglomerans
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $99.2 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cyclo(Phe-Gly) shows weak antagonistic activity against VEGFR2 -CD, it also shows strong inhibitory activity against human cancer cells(KB,KBv200) with LD50 at 6.5 and 11.2 umol/L,respectively.
Targets: IFN-γ | IL Receptor | HSP (e.g. HSP90) | VEGFR
In vitro:
Chinese Journal of Antibiotics,2014,6:408-12,421.
Discovery on antagonists of VEGFR2-CD produced by Streptomyces strain I06A-02832[Reference: WebLink]
To discover antagonists of VEGFR2-CD from the fermentation broth produced by streptomyces strain I06A-02832.
METHODS AND RESULTS:
Under the guidance of ELISA assay against VEGFR2-CD, Compounds 2832 B and 2832 C were isolated and purified by combination of different column chromatographies and HPLC. The structures of compounds 2832 B and C were identified by combination of analysis of UV, IR, MS and 1D-NMR, 2D-NMR. Compounds 2832 B and 2832 C were purified and structurally identified as cyclic dipeptides, and were the same with cyclo-(Pro-Tyr) and Cyclo(Phe-Gly) respectively. Compounds 2832 B and 2832 C showed weak antagonistic activity against VEGFR2-CD by ELISA assay.
CONCLUSIONS:
They are firstly reported compounds 2832 B and 2832 C had antagonistic activity against VEGFR2-CD.
Hubei Agricultural Sciences, 2013, 52 (11) :2558- 61.
Study on the Metabolites of Mangrove Endophytic Fungus GX-3 from the South China Sea[Reference: WebLink]

METHODS AND RESULTS:
The secondary metabolite compounds of mangrove endophytic fungus GX-3 from the South China Sea were isolated by column chromatography and identified on the basis of physic-chemical constants and spectral analysis.Six metabolites were obtained and elucidated as Cyclo(Phe-Gly) (1),cyclo-(Leu-Gly)(2),Fusaric acid(3),3,6-di-sec-butyl-1,4-dihydroxypiperazine-2,5-dione(4),cyclo-(pro-leu)(5),cyclo-(Gly-Leu)(6).
CONCLUSIONS:
In the preliminary bioassay,1 showed strong inhibitory activity against KB,KBv200 with LD50 at 6.5 and 11.2 μmol/L,respectively.The six metabolites were obtained from endophytic fungus GX-3 for the first time.
Cyclo(Phe-Gly) Description
Source: From Pantoea agglomerans
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.8964 mL 24.4822 mL 48.9644 mL 97.9288 mL 122.411 mL
5 mM 0.9793 mL 4.8964 mL 9.7929 mL 19.5858 mL 24.4822 mL
10 mM 0.4896 mL 2.4482 mL 4.8964 mL 9.7929 mL 12.2411 mL
50 mM 0.0979 mL 0.4896 mL 0.9793 mL 1.9586 mL 2.4482 mL
100 mM 0.049 mL 0.2448 mL 0.4896 mL 0.9793 mL 1.2241 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Animal Research:
Fish Shellfish Immunol. 2015 Jul;45(1):124-31.
Enhancement of secondary metabolites from Bacillus Licheniformis XY-52 on immune response and expression of some immune-related genes in common carp, Cyprinus carpio.[Pubmed: 25703710]

METHODS AND RESULTS:
This study was undertaken to isolate active secondary metabolites from immunostimulatory Bacillus Licheniformis XY-52 and evaluate their activities at 0%, 0.5%, 1.0%, and 2.0% doses supplementation with feed on immune response in common carp at weeks 1, 2, and 3. By applying chromatography techniques and successive recrystallization, two purified metabolites were obtained and identified by spectral data (mass spectrometry and nuclear magnetic resonance) as: Cyclo(Phe-Tyr) and Cyclo(Phe-Gly). The results revealed that humoral innate immune parameters (lysozyme activity, phagocytic activity and bactericidal activity) were significantly (P < 0.05) increased after feeding on the two active compounds-supplemented diet. Furthermore, administration of the two active compounds significantly (P < 0.05) up regulated IL-1β, Type 1 IFN, IFN g2b, IL10 and TNF-α gene expression. Heat shock protein 70 (HSP70) gene expression was significantly (P < 0.05) lower as compared to control group at the end of trial. Common carp fed with the two compounds had higher survival rates (69.3%) compared to the controls (32.0%) after challenged with the pathogen, Aeromonas hydrophila.
CONCLUSIONS:
The present study indicates that the two isolated active compounds could positively influence immune response and enhance disease resistance of common carp against A. hydrophila infection.
Structure Identification:
Nat Prod Commun. 2013 Dec;8(12):1753-4.
A new cyclopeptide from endophytic Streptomyces sp. YIM 64018.[Pubmed: 24555291]
One new cyclopeptide, cyclo(L-Phe-L-Ala-L-Phe-Gly), named as vinaceuline (1) and three known cyclodipeptides, Cyclo(Phe-Gly), cyclo(Phe-4-hydroxyl-Pro) and cyclo(Phe-Ile) were isolated from broth culture of endophytic Streptomyces YIM 64018 associated with Paraboea sinensis.
METHODS AND RESULTS:
The planar structure of the new compound was assigned on the basis of 1D and 2D NMR spectroscopic techniques, while t he a bsolute configurations of the amino acid residueswere determined by application of the advanced Marfey method.

CONCLUSIONS:
Cyclotetrapeptides are rarely found as Streptomycete metabolites.
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