Cyclo(Pro-Ala) | CAS:65556-33-4 | Manufacturer ChemFaces

Cyclo(Pro-Ala)

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Product Name	Cyclo(Pro-Ala)
Price:	$218 / 10mg
CAS No.:	65556-33-4
Catalog No.:	CFN90282
Molecular Formula:	C₈H₁₂N₂O₂
Molecular Weight:	168.20 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The roots of Rubia schumanniana Pritzel
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / $77.9 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Cyclo(Pro-Ala) is a new cell cycle inhibitor.

In vitro:

Journal of Shenyang Pharmaceutical University, 2015(2):107 -10.

Cyclic dipeptides as new cell cycle inhibitors produced by Streptomyces flavoretus [Reference: WebLink]

To find the cell cycle inhibitors from the metabolites of Streptomyces flavoretus 18522.
METHODS AND RESULTS:
Activity-guided isolation was performed on the chloroform extract of the fermentation broth and mycelia of Streptomyces flavoretus 18522 by using ts FT210 cells.Compounds were isolated through various chromatoghraphic methods and elucidated by spectroscopic means.The flow cytometry was used to evaluate the cell cycle inhibiting activity of the fractions and compounds. Six cyclic dipeptides were obtained and identified as cyclo(Ala-Leu)(1),cyclo(Ala-Ile)(2),cyclo(Ala-Val)(3),cyclo(Phe-Leu)(4),Cyclo(Pro-Ala)(5) and cyclo(Phe-Val)(6).
CONCLUSIONS:
Compounds 1-6 are reported as new cell cycle inhibitors for the first time.

Cyclo(Pro-Ala) Description

Source:	The roots of Rubia schumanniana Pritzel
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Int J Pept Protein Res. 1985 Nov;26(5):518-27.

Theoretical pi-pi* absorption and circular dichroic spectra of cyclic dipeptides.[Pubmed: 4086166]

METHODS AND RESULTS:
The dipole interaction model, treated by the partially dispersive normal mode method, is used to calculate circular dichroic spectra of cyclo(Gly-Gly), cyclo (Ala-Gly), cyclo(Ala-Ala), cyclo(Pro-Gly), Cyclo(Pro-Ala), cyclo(Pro-Val), cyclo (Pro-D-Val), and cyclo(Pro-Pro) in the amide pi-pi* absorption band near 190 nm. Assuming a standard backbone geometry, spectra which are in fair to good agreement with experiment are obtained for these molecules. The spectra are predicted to be sensitive to conformations of Pro and Val side chains. The effects of dipeptide ring folding on calculated CD spectra are mostly consistent with those found by other workers, except that it is found that a planar ring conformation of cyclo (Ala-Ala) and cyclo (Ala-Gly) gives predicted spectra comparable to experiment.
CONCLUSIONS:
The same model gives theoretical absorption spectra consistent with available experimental data.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Anti-mitotic Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.9453 mL	29.7265 mL	59.453 mL	118.9061 mL	148.6326 mL
5 mM	1.1891 mL	5.9453 mL	11.8906 mL	23.7812 mL	29.7265 mL
10 mM	0.5945 mL	2.9727 mL	5.9453 mL	11.8906 mL	14.8633 mL
50 mM	0.1189 mL	0.5945 mL	1.1891 mL	2.3781 mL	2.9727 mL
100 mM	0.0595 mL	0.2973 mL	0.5945 mL	1.1891 mL	1.4863 mL

CFN96160	Cyclo(Gly-L-Pro)	3705-27-9	154.2	C₇H₁₀N₂O₂
CFN90282	Cyclo(Pro-Ala)	65556-33-4	168.20	C₈H₁₂N₂O₂
CFN96111	Cyclo(L-Ala-L-Pro)	36357-32-1	168.2	C₈H₁₂N₂O₂
CFN91572	Cyclo(Ser-Pro)	1355217-25-2	184.2	C₈H₁₂N₂O₃
CFN90275	Cyclo(Pro-Val)	5654-87-5	196.25	C₁₀H₁₆N₂O₂
CFN96114	Cyclo(D-Val-L-Pro)	27483-18-7	196.3	C₁₀H₁₆N₂O₂
CFN91062	Cyclo(Hyp-Val)	1425501-89-8	212.2	C₁₀H₁₆N₂O₃
CFN90281	Cyclo(Pro-Leu)	5654-86-4	210.27	C₁₁H₁₈N₂O₂
CFN96128	Cyclo(D-Leu-L-Pro)	36238-67-2	210.3	C₁₁H₁₈N₂O₂
CFN90285	Cyclo(Hpro-Leu)	1016899-93-6	226.27	C₁₁H₁₈N₂O₃