Science | Nature | Cell | View More
Natural Products
Cyclo(Tyr-Gly)
Cyclo(Tyr-Gly)
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cyclo(Tyr-Gly)
Price: $238 / 10mg
CAS No.: 5625-49-0
Catalog No.: CFN90269
Molecular Formula: C11H12N2O3
Molecular Weight: 220.22 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: From Gliocladium virens
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $99.2 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Vigo (Spain)
  • University of Wisconsin-Madison (USA)
  • Kyushu University (Japan)
  • Sapienza University of Rome (Italy)
  • University of Otago (New Zealand)
  • The Australian National University (Australia)
  • Hamdard University (India)
  • Sant Gadge Baba Amravati Univer... (India)
  • Srinakharinwirot University (Thailand)
  • Sri Ramachandra University (India)
  • Technical University of Denmark (Denmark)
  • More...
Package
Featured Products
3,7-Di-O-methylquercetin

Catalog No: CFN96221
CAS No: 2068-02-2
Price: $/mg
Euphorbia factor L2

Catalog No: CFN92884
CAS No: 218916-51-9
Price: $40/20mg
8-Shogaol

Catalog No: CFN92299
CAS No: 36700-45-5
Price: $368/20mg
2'-Hydroxydaidzein

Catalog No: CFN97687
CAS No: 7678-85-5
Price: $ /
Acacetin

Catalog No: CFN98744
CAS No: 480-44-4
Price: $30/20mg
Astin C

Catalog No: CFN95189
CAS No: 148057-23-2
Price: $318/10mg
Stigmasterol

Catalog No: CFN97326
CAS No: 83-48-7
Price: $30/20mg
Tanshinone I

Catalog No: CFN98953
CAS No: 568-73-0
Price: $30/20mg
Myricetin

Catalog No: CFN98877
CAS No: 529-44-2
Price: $40/20mg
Kukoamine B

Catalog No: CFN93216
CAS No: 164991-67-7
Price: $268/10mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Reference standards.
In vitro:
Studies in Organic Chemistry, 1998, 53(98):167-171.
Microbial degradation of 2,5-diketopiperazines.[Reference: WebLink]

METHODS AND RESULTS:
Enrichment culture of soil samples with cyclo(Gly-Gly) and cyclo(Gly-l-Tyr) as a carbon and/or a nitrogen source resulted in the isolation of Arthrobacter sp. 1-3-1 and the coryneform rod bacterium, strain T-1-3-Y, as the bacteria which most highly assimilated cyclo(Gly-Gly) and cyclo(Gly-l-Tyr), respectively. Both bacteria had the enzyme activity hydrolyzing DKPs intracellularly in contrast to the extracellular cyclo(Gly-Gly) hydrolase reported previously. The cells of Arthrobacter sp. 1-3-1 degraded all diketopiperazines tested, including cyclo(Gly-Gly), cyclo(Gly-l-Ala), cyclo(Gly-l-Val), cyclo(Gly-l-Leu), cyclo(Gly-l-Ile), cyclo(Gly-l-Met), cyclo(Gly-l-Phe), cyclo(Gly-l-Tyr)(Cyclo(Tyr-Gly)), cyclo(l-Ala-l-Tyr), cyclo(l-Val-l-Tyr), cyclo(l-Leu-l-Tyr), cyclo(l-Tyr-l-Tyr), cyclo(l-Phe-l-Leu), cyclo(Gly-d-Ala), and cyclo(Gly-d-Leu). On the other hand, the degradation of d-amino acid-containing DKPs or cyclo(Gly-Gly) by the cells of the strain T-1-3-Y were detected hardly or not at all, respectively.
CONCLUSIONS:
From the result that DKP hydrolase in the strain T-1-3-Y had a higher stereospecificity than that in Arthrobacter sp. 1-3-1, the diversity of DKP hydrolases were found to be in nature.
Cyclo(Tyr-Gly) Description
Source: From Gliocladium virens
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Fuzitine

Catalog No: CFN95337
CAS No: 142287-96-5
Price: $318/5mg
Fortunellin-6''-beta-D-glucopyrano...

Catalog No: CFN95315
CAS No: 1218774-64-1
Price: $318/5mg
4-O-Coumaroylquinic acid

Catalog No: CFN95508
CAS No: 53539-37-0
Price: $318/5mg
12-Acetoxy ganoderic acid D

Catalog No: CFN95535
CAS No: N/A
Price: $318/5mg
New compound 16

Catalog No: CFN95465
CAS No: N/A
Price: $413/5mg
Cannabisin P

Catalog No: CFN95456
CAS No: 2756983-19-2
Price: $318/5mg
Apigenin 4'-O-(2'',6''-di-O-E-p-co...

Catalog No: CFN95276
CAS No: 71781-79-8
Price: $318/10mg
Somnifericin

Catalog No: CFN95280
CAS No: 173693-57-7
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.5409 mL 22.7046 mL 45.4091 mL 90.8183 mL 113.5228 mL
5 mM 0.9082 mL 4.5409 mL 9.0818 mL 18.1637 mL 22.7046 mL
10 mM 0.4541 mL 2.2705 mL 4.5409 mL 9.0818 mL 11.3523 mL
50 mM 0.0908 mL 0.4541 mL 0.9082 mL 1.8164 mL 2.2705 mL
100 mM 0.0454 mL 0.227 mL 0.4541 mL 0.9082 mL 1.1352 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chinese Journal of Antibiotics, 2005-08.
Antitumor components from marine actinomycete 11014: I. Cyclic dipeptides.[Reference: WebLink]

METHODS AND RESULTS:
To explore the antitumor active components in fermentation of a marine actinomycete 11014, 13 cyclic dipetides were isolated and purified by using solvent extraction, silica gel column and preparation HPLC. The separation procedure was guided by a bioassay using tsFT210 cell lines. By means of physicochemical properties and spectral analysis, their structures were respectively determined as: cyclo-(Leu-Ala), cyclo-(Leu-Gly), cyclo-(Ile-Ala), cyclo-(Val-Ala), cyclo-(Ala-Phe), cyclo-(Phe-Gly), Cyclo(Tyr-Gly), cyclo-(Pro-Tyr), cyclo-(Pro-Phe), cyclo-(4-hydroxyl-Pro-Phe), cyclo-(4-hydroxyl-Pro-Leu), cyclo-(Pro-Val), cyclo-(Pro-Leu). The antitumor activities of these compounds were firstly assayed by sulfo rhodamine B method.
CONCLUSIONS:
Cyclo-(4-hydroxyl-Pro-Phe) showed cytotoxicity against tsFT210 cell lines with inhibitory rate of 48. 3% at the concentration of 5 μg/ml.
3,7-Di-O-methylquercetin

Catalog No: CFN96221
CAS No: 2068-02-2
Price: $/mg
Euphorbia factor L2

Catalog No: CFN92884
CAS No: 218916-51-9
Price: $40/20mg
8-Shogaol

Catalog No: CFN92299
CAS No: 36700-45-5
Price: $368/20mg
2'-Hydroxydaidzein

Catalog No: CFN97687
CAS No: 7678-85-5
Price: $ /
Acacetin

Catalog No: CFN98744
CAS No: 480-44-4
Price: $30/20mg
Astin C

Catalog No: CFN95189
CAS No: 148057-23-2
Price: $318/10mg
Stigmasterol

Catalog No: CFN97326
CAS No: 83-48-7
Price: $30/20mg
Tanshinone I

Catalog No: CFN98953
CAS No: 568-73-0
Price: $30/20mg
Myricetin

Catalog No: CFN98877
CAS No: 529-44-2
Price: $40/20mg
Kukoamine B

Catalog No: CFN93216
CAS No: 164991-67-7
Price: $268/10mg
Tags: buy Cyclo(Tyr-Gly) | Cyclo(Tyr-Gly) supplier | purchase Cyclo(Tyr-Gly) | Cyclo(Tyr-Gly) cost | Cyclo(Tyr-Gly) manufacturer | order Cyclo(Tyr-Gly) | Cyclo(Tyr-Gly) distributor