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Cyclo(Tyr-Gly)
Cyclo(Tyr-Gly)
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cyclo(Tyr-Gly)
Price: $238 / 10mg
CAS No.: 5625-49-0
Catalog No.: CFN90269
Molecular Formula: C11H12N2O3
Molecular Weight: 220.22 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: From Gliocladium virens
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Reference standards.
In vitro:
Studies in Organic Chemistry, 1998, 53(98):167-171.
Microbial degradation of 2,5-diketopiperazines.[Reference: WebLink]

METHODS AND RESULTS:
Enrichment culture of soil samples with cyclo(Gly-Gly) and cyclo(Gly-l-Tyr) as a carbon and/or a nitrogen source resulted in the isolation of Arthrobacter sp. 1-3-1 and the coryneform rod bacterium, strain T-1-3-Y, as the bacteria which most highly assimilated cyclo(Gly-Gly) and cyclo(Gly-l-Tyr), respectively. Both bacteria had the enzyme activity hydrolyzing DKPs intracellularly in contrast to the extracellular cyclo(Gly-Gly) hydrolase reported previously. The cells of Arthrobacter sp. 1-3-1 degraded all diketopiperazines tested, including cyclo(Gly-Gly), cyclo(Gly-l-Ala), cyclo(Gly-l-Val), cyclo(Gly-l-Leu), cyclo(Gly-l-Ile), cyclo(Gly-l-Met), cyclo(Gly-l-Phe), cyclo(Gly-l-Tyr)(Cyclo(Tyr-Gly)), cyclo(l-Ala-l-Tyr), cyclo(l-Val-l-Tyr), cyclo(l-Leu-l-Tyr), cyclo(l-Tyr-l-Tyr), cyclo(l-Phe-l-Leu), cyclo(Gly-d-Ala), and cyclo(Gly-d-Leu). On the other hand, the degradation of d-amino acid-containing DKPs or cyclo(Gly-Gly) by the cells of the strain T-1-3-Y were detected hardly or not at all, respectively.
CONCLUSIONS:
From the result that DKP hydrolase in the strain T-1-3-Y had a higher stereospecificity than that in Arthrobacter sp. 1-3-1, the diversity of DKP hydrolases were found to be in nature.
Cyclo(Tyr-Gly) Description
Source: From Gliocladium virens
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

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doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.5409 mL 22.7046 mL 45.4091 mL 90.8183 mL 113.5228 mL
5 mM 0.9082 mL 4.5409 mL 9.0818 mL 18.1637 mL 22.7046 mL
10 mM 0.4541 mL 2.2705 mL 4.5409 mL 9.0818 mL 11.3523 mL
50 mM 0.0908 mL 0.4541 mL 0.9082 mL 1.8164 mL 2.2705 mL
100 mM 0.0454 mL 0.227 mL 0.4541 mL 0.9082 mL 1.1352 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chinese Journal of Antibiotics, 2005-08.
Antitumor components from marine actinomycete 11014: I. Cyclic dipeptides.[Reference: WebLink]

METHODS AND RESULTS:
To explore the antitumor active components in fermentation of a marine actinomycete 11014, 13 cyclic dipetides were isolated and purified by using solvent extraction, silica gel column and preparation HPLC. The separation procedure was guided by a bioassay using tsFT210 cell lines. By means of physicochemical properties and spectral analysis, their structures were respectively determined as: cyclo-(Leu-Ala), cyclo-(Leu-Gly), cyclo-(Ile-Ala), cyclo-(Val-Ala), cyclo-(Ala-Phe), cyclo-(Phe-Gly), Cyclo(Tyr-Gly), cyclo-(Pro-Tyr), cyclo-(Pro-Phe), cyclo-(4-hydroxyl-Pro-Phe), cyclo-(4-hydroxyl-Pro-Leu), cyclo-(Pro-Val), cyclo-(Pro-Leu). The antitumor activities of these compounds were firstly assayed by sulfo rhodamine B method.
CONCLUSIONS:
Cyclo-(4-hydroxyl-Pro-Phe) showed cytotoxicity against tsFT210 cell lines with inhibitory rate of 48. 3% at the concentration of 5 μg/ml.
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