Daturametelin I | CAS:904667-65-8 | Manufacturer ChemFaces

Daturametelin I

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Description:

Reference standards.

In vitro:

Chemistry & Biodiversity, 2006, 3(2):180-6

Daturametelins H, I, and J: Three New Withanolide Glycosides from Datura metel L.[Reference: WebLink]

METHODS AND RESULTS:
Three new withanolide glycosides named daturametelins H, Daturametelin I, daturametelin J (1-3), together with two known ones, daturataturin A (4) and 7,27-dihydroxy-1-oxowitha-2,5,24-trienolide (5), were isolated from the MeOH extract of the aerial parts of Datura metel L. (Solanaceae). Their structures were determined mainly by spectroscopic techniques including 2D-NMR (HMBC, HMQC, (1)H,(1)H-COSY, NOESY) and MS experiments. Compounds 1-5 were tested for their antiproliferative activity towards the human colorectal carcinoma (HCT-116) cell line.
CONCLUSIONS:
The nonglycosidic compound 5 exhibited the highest activity of the tested withanolides, with an IC(50) value of 3.2+/-0.2 microM (Table 3).

Daturametelin I Description

Source:	The herbs of Datura tatura.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Frontiers in Pharmacology, 2018, 9:731.

Metabolites Identification of Bioactive Compounds Daturataturin A, Daturametelin I, N-Trans-Feruloyltyramine, and Cannabisin F From the Seeds of Datura metel in Rats.[Reference: WebLink]

Datura metel L. is a widely used traditional herbal medicine, and withanolides and amides are the two groups of main bioactive constituents in Datura metel seeds. This study aimed to elucidate the metabolism of four representative bioactive compositions containing daturataturin A (1), Daturametelin I (2), N-trans-feruloyltyramine (3), and cannabisin F (4) in rats.
METHODS AND RESULTS:
After separately oral administration of 20 mg/kg withanolides (1, 2) and amides (3, 4) to rats, a total of 12, 24, and 21 metabolites were detected in the plasma, urine, and fecal samples, respectively. Among them, three hydroxylated metabolites, 1-M3, 2-M2, and 3-M5, were detected in plasma and rat liver microsome incubation system in high abundance. Two metabolites of 1 and 2 were unambiguously identified by comparing with reference standards. Particularly, the methylated metabolite 27α-methoxy-(22R)-22,26-epoxy-27-[(β-D-glucopyranosyl)oxy]ergosta-2,4,6,24-tetraene-1,26-dione (daturametelin L) is a new compound.
CONCLUSIONS:
The withanolides could readily get hydroxylation or methylation metabolism. Meanwhile, the phase II metabolism (glucuronidation or sulfation) was the major reaction for the amides. This is the first study on in vivo metabolism of these active compounds in seeds of Datura metel.

Product Name	Daturametelin I
Price:
CAS No.:	904667-65-8
Catalog No.:	CFN97468
Molecular Formula:	C₃₄H₄₈O₁₀
Molecular Weight:	616.8 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The herbs of Datura tatura.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Steroids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6213 mL	8.1064 mL	16.2127 mL	32.4254 mL	40.5318 mL
5 mM	0.3243 mL	1.6213 mL	3.2425 mL	6.4851 mL	8.1064 mL
10 mM	0.1621 mL	0.8106 mL	1.6213 mL	3.2425 mL	4.0532 mL
50 mM	0.0324 mL	0.1621 mL	0.3243 mL	0.6485 mL	0.8106 mL
100 mM	0.0162 mL	0.0811 mL	0.1621 mL	0.3243 mL	0.4053 mL

CFN96435	Withanolide C	108030-78-0	523.05	C₂₈H₃₉ClO₇
CFN91964	Withanolide A	32911-62-9	470.60	C₂₈H₃₈O₆
CFN91967	6alpha-Chloro-5beta-hydroxywithaferin A	52329-20-1	507.06	C₂₈H₃₉ClO₆
CFN91963	Withanolide B	56973-41-2	454.60	C₂₈H₃₈O₅
CFN89289	4beta-Hydroxywithanolide E	54334-04-2	502.60	C₂₈H₃₈O₈
CFN95280	Somnifericin	173693-57-7	490.6	C₂₈H₄₂O₇
CFN91969	2,3-Didehydrosomnifericin	173614-88-5	488.61	C₂₈H₄₀O₇
CFN91965	Baimantuoluoside C	60124-17-6	470.60	C₂₈H₃₈O₆
CFN97467	Daturataturin A aglycone	904665-71-0	454.6	C₂₈H₃₈O₅
CFN96990	Phyperunolide E	1198400-52-0	520.61	C₂₈H₄₀O₉