Deacetyltaxol | CAS:78432-77-6 | Manufacturer ChemFaces

Deacetyltaxol

ChemFaces products have been cited in many studies from excellent and top scientific journals

Product Name	Deacetyltaxol
Price:	$90 / 20mg
CAS No.:	78432-77-6
Catalog No.:	CFN90687
Molecular Formula:	C₄₅H₄₉NO₁₃
Molecular Weight:	811.87 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The barks of Taxus chinensis (Pilger) Rehd.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $36.3 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

10-Deacetyltaxol and cephalomannine have cytotoxicity in human glial and neuroblastoma cell-lines, the tumors of the central and peripheral nervous system are sensitive to 10-deacetyltaxol and cephalomannine and these drugs are less toxic than taxol but remain within a therapeutic range.

In vitro:

Int. J.Oncol., 1993, 2(2):297-9.

Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines.[Pubmed: 21573554]

METHODS AND RESULTS:
The cytotoxic effects of taxol, 10-Deacetyltaxol, and cephalomannine at concentrations of 0.1 mug/ml to 10.0 mug/ml for one and 24 hours exposure were determined in two human glioblastoma multiforme and two neuroblastoma cell lines using the MTT method. The neuroblastoma cell lines were established from previously treated patients, while the glioblastomas were from untreated patients. There was a proportionate concentration-toxicity relationship for all four cell lines. The neuroblastoma SK-N-FI was consistently the most resistant to all three drugs. The order of potency after a one hour exposure was taxol, 10-Deacetyltaxol and cephalomannine. Cephalomannine contained 1.5% taxol impurity and 10-Deacetyltaxol, 4.5% taxol hence the contribution of taxol to these substances' toxic effects was minimal.
CONCLUSIONS:
We conclude that tumors of the central and peripheral nervous system are sensitive to 10-Deacetyltaxol and cephalomannine and these drugs are less toxic than taxol but remain within a therapeutic range.

Deacetyltaxol Description

Source:	The barks of Taxus chinensis (Pilger) Rehd.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Cytotoxic Compound Library Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2317 mL	6.1586 mL	12.3172 mL	24.6345 mL	30.7931 mL
5 mM	0.2463 mL	1.2317 mL	2.4634 mL	4.9269 mL	6.1586 mL
10 mM	0.1232 mL	0.6159 mL	1.2317 mL	2.4634 mL	3.0793 mL
50 mM	0.0246 mL	0.1232 mL	0.2463 mL	0.4927 mL	0.6159 mL
100 mM	0.0123 mL	0.0616 mL	0.1232 mL	0.2463 mL	0.3079 mL

CFN98516	N-Debenzoyl-N-(tert-butoxycarbonyl)taxol	125354-16-7	849.92	C₄₅H₅₅NO₁₅
CFN98518	Cephalomannine	71610-00-9	831.91	C₄₅H₅₃NO₁₄
CFN90687	Deacetyltaxol	78432-77-6	811.87	C₄₅H₄₉NO₁₃
CFN90371	7-Epitaxol	105454-04-4	853.91	C₄₇H₅₁NO₁₄
CFN97759	Paclitaxel	33069-62-4	853.92	C₄₇H₅₁NO₁₄
CFN98515	7-Xylosyltaxol	90332-66-4	986.0	C₅₂H₅₉NO₁₈
CFN90837	10-Deacetyl-7-xylosyl paclitaxel	90332-63-1	944.0	C₅₀H₅₇NO₁₇
CFN89397	7-Epi-10-deacetyltaxol	78454-17-8	811.86	C₄₅H₄₉NO₁₃
CFN89395	7-Epi-10-deacetylcephalomannine	78479-12-6	789.86	C₄₃H₅₁NO₁₃
CFN95519	10-Deacetylcephalomannine	76429-85-1	789.9	C₄₃H₅₁NO₁₃