Dehydrocorydaline nitrate | CAS:13005-09-9

Dehydrocorydaline nitrate

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Dehydrocorydaline nitrate Description

Source:	The tubers of Corydalis ambigua
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Int. Immunopharmacol., 2011, 11(9):1362-7.

Dehydrocorydaline inhibits elevated mitochondrial membrane potential in lipopolysaccharide-stimulated macrophages.[Pubmed: 21575743 ]

Activated macrophages play a critical role in the pathogenesis of numerous diseases by producing pro-inflammatory cytokines such as interleukin (IL)-1β and IL-6. While the mechanisms of bacterial component recognition and signal transduction have been well investigated, viability regulation in activated macrophages remains unclear.
METHODS AND RESULTS:
We screened herbal ingredients to find an agent that reduces the viability of lipopolysaccharide (LPS)-stimulated macrophages and observed that dehydrocorydaline, a component of Corydalis yanhusuo, reduced the viability of macrophage-derived RAW264.7 cells and primary macrophages in the presence of LPS. Dehydrocorydaline inhibited the elevation of mitochondrial membrane potential and induced ATP depletion in LPS-stimulated macrophages but neither affected basal mitochondrial membrane potential nor ATP content in non-stimulated macrophages. Dehydrocorydaline also prevented increased concentrations of IL-1β and IL-6 in culture media of LPS-stimulated macrophages.
CONCLUSIONS:
Mode of dehydrocorydaline action indicates that elevated mitochondrial membrane potential may be a novel target to specifically reduce viability and suppress cytokine production in LPS-stimulated macrophages.

Product Name	Dehydrocorydaline nitrate
Price:
CAS No.:	13005-09-9
Catalog No.:	CFN90604
Molecular Formula:	C₂₂H₂₄NO₄.NO₃
Molecular Weight:	428.44 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The tubers of Corydalis ambigua
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Analgesia Compound Library Anti-allergy Compound Library Alkaloids Compound Library IL Receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.334 mL	11.6702 mL	23.3405 mL	46.681 mL	58.3512 mL
5 mM	0.4668 mL	2.334 mL	4.6681 mL	9.3362 mL	11.6702 mL
10 mM	0.2334 mL	1.167 mL	2.334 mL	4.6681 mL	5.8351 mL
50 mM	0.0467 mL	0.2334 mL	0.4668 mL	0.9336 mL	1.167 mL
100 mM	0.0233 mL	0.1167 mL	0.2334 mL	0.4668 mL	0.5835 mL

CFN95179	Yuanhunine	104387-15-7	355.4	C₂₁H₂₅NO₄
CFN90196	Corydaline	518-69-4	369.44	C₂₂H₂₇NO₄
CFN90330	Dehydrocorydalin	30045-16-0	366.44	C₂₂H₂₄NO₄
CFN91411	Tetradehydrothalictrifoline	114073-47-1	350.4	C₂₁H₂₀NO₄
CFN90407	Dehydrocavidine	83218-34-2	348.4	C₂₁H₁₈NO₄
CFN90604	Dehydrocorydaline nitrate	13005-09-9	428.44	C₂₂H₂₄NO₄.NO₃
CFN90415	Worenine	38763-29-0	334.11	C₂₀H₁₆NO₄+
CFN95587	New compound 23	N/A	334.4	C₂₀H₁₆NO₄+
CFN91710	Corysamine chloride	11028-77-6	369.8	C₂₀H₁₆ClNO₄