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Dehydroglaucine
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Product Name Dehydroglaucine
Price:
CAS No.: 22212-26-6
Catalog No.: CFN90406
Molecular Formula: C21H23NO4
Molecular Weight: 353.41 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Cryst.
Source: The tubers of Corydalis yanhusuo
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Dehydroglaucine is an acetylcholinesterase inhibitor, it shows antimicrobial activity against Staphylococcus aureus, Mycobacterium smegmatis, Candida albicans, and Aspergillus niger.
Targets: Antifection
In vitro:
Journal of Pharmaceutical Sciences, 1975, 64(5):789-792.
Two antimicrobial alkaloids from heartwood of Liriodendron tulipifera L.[Reference: WebLink]
Alcoholic extracts of the heartwood of Liriodendron tulipifera have demonstrated antimicrobial activity against Staphylococcus aureus, Mycobacterium smegmatis, Candida albicans, and Aspergillus niger. The antimicrobial activity was associated only with the alkaloidal fraction.
METHODS AND RESULTS:
Separation of the active alkaloidal fraction by chromatography led to the isolation and identification of Dehydroglaucine and liriodenine as the active components.
CONCLUSIONS:
Several other alkaloidal derivatives were prepared and tested. In addition to the active alkaloids, michelabine was also identified in the tertiary nonphenolic base fraction along with the lignan, lirioresinol-B-dimethyl ether, and two N-acetylnoraporphine alkaloids from the nonbasic fraction.
Dehydroglaucine Description
Source: The tubers of Corydalis yanhusuo
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8296 mL 14.1479 mL 28.2957 mL 56.5915 mL 70.7394 mL
5 mM 0.5659 mL 2.8296 mL 5.6591 mL 11.3183 mL 14.1479 mL
10 mM 0.283 mL 1.4148 mL 2.8296 mL 5.6591 mL 7.0739 mL
50 mM 0.0566 mL 0.283 mL 0.5659 mL 1.1318 mL 1.4148 mL
100 mM 0.0283 mL 0.1415 mL 0.283 mL 0.5659 mL 0.7074 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
RSC Adv. 2016, 6(100):98476-98486.
Zeolite based solid-phase extraction coupled with UPLC-Q-TOF-MS for rapid analysis of acetylcholinesterase binders from crude extract of Corydalis yanhusuo.[Reference: WebLink]
A very convenient, sensitive and precise solid-phase extraction approach was established for extract and analysis of acetylcholinesterase binders from crude extract of Corydalis yanhusuo.
METHODS AND RESULTS:
This approach was based on the retention of binders by acetylcholinesterase immobilized zeolite. The retained acetylcholinesterase binders were eluted and analyzed by ultra-high performance liquid chromatography and quadrupole-time-of-flight mass spectrometry. The powder X-ray diffraction (XRD), transmission electron microscopy (TEM), and Fourier transform infrared (FT-IR) spectroscopy techniques were employed for the characterization of acetylcholinesterase immobilized zeolite. Some experimental conditions such as incubation temperature, time, buffer pH and ion strength, which may affect binding capability, were investigated by using coptisine as a model inhibitor. The optimal incubation conditions were as follows: wash times: 4, wash solvent: 50% methanol-water, incubation time: 20 min, temperature: 37 °C, ion strength: 10 mM, pH: 7.4. The proposed approach was successfully applied for the extraction of acetylcholinesterase binders from crude extract of Corydalis yanhusuo. These binders were further validated by acetylcholinesterase inhibitory assay.
CONCLUSIONS:
Fourteen acetylcholinesterase inhibitors were identified, and ten of which, including dehydrocorydaline, allocryptopine, corydaline, Dehydroglaucine, protopine, tetrahydrocoptisine, tetrahydropalmatine, corynoline, tetrahydrocolumbamne and tetrahydroberberine, were reported for the first time. In addition, the merits and shortcomings of zeolite based solid-phase extraction approach were compared with that of magnetic nanoparticles based solid-phase extraction approach.
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