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Dihydrophaseic acid
Dihydrophaseic acid
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Dihydrophaseic acid
Price:
CAS No.: 41756-77-8
Catalog No.: CFN98657
Molecular Formula: C15H22O5
Molecular Weight: 282.3 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Powder
Source: The herbs of Echinocystis macrocarpa
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Dihydrophaseic acid 3’-O-b-D-glucopyranoside (D3G) can increase the proliferation and differentiation of osteoblast cells and enhance bone formation, suggests that D3G may be a good candidate for the treatment of osteoporosis.
In vitro:
Osteoporosis and Sarcopenia 2015,1(2):137-8.
Antiosteoporotic Activity of Dihydrophaseic Acid 3′-O-b-D-Glucopyranoside Derivatives from Lycii Radicis Cortex.[Reference: WebLink]
Our previous study demonstrated that ethanol extract of Lycii Radicis Cortex (LRC) prevented the ovariectomized-induced bone mineral density loss in mice via promoting the differentiation of osteoblast linage cells. A single compound, D3G, was isolated from the LRC extract as a candidate component enhancing bone formation. The aim of this study was to investigate the antiosteoporotic effects of Dihydrophaseic acid 3ʹ-O-b-D-glucopyranoside (D3G).
METHODS AND RESULTS:
The highest alkaline phosphatase activity was observed with 5 μg/ml of D3G in both cell lines: C3H10T1/2 and MC3T3-E1. The D3G treatment for 21 days increased the mineralized nodule formation in the MC3T3-E1 cell line. The expression of osteoblastic markers, Alpl, Runx2, and Bglap, was significantly increased in the D3G-treated cells compared to the non-treated control cells. The D3G treatment did not influence osteoclast differentiation in primary-cultured monocytes of mouse bone marrow. In coculture of monocytes and MC3T3-E1 cells, however, D3G induced both osteoblast and osteoclast differentiation.
CONCLUSIONS:
This study demonstrated that D3G increased the proliferation and differentiation of osteoblast cells and enhanced bone formation. These results suggest that D3G may be a good candidate for the treatment of osteoporosis
Dihydrophaseic acid Description
Source: The herbs of Echinocystis macrocarpa
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
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IF=36.216(2019)

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doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

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IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5423 mL 17.7117 mL 35.4233 mL 70.8466 mL 88.5583 mL
5 mM 0.7085 mL 3.5423 mL 7.0847 mL 14.1693 mL 17.7117 mL
10 mM 0.3542 mL 1.7712 mL 3.5423 mL 7.0847 mL 8.8558 mL
50 mM 0.0708 mL 0.3542 mL 0.7085 mL 1.4169 mL 1.7712 mL
100 mM 0.0354 mL 0.1771 mL 0.3542 mL 0.7085 mL 0.8856 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Plant Physiol. 1981 Jul;68(1):93-5.
Identification of a dihydrophaseic Acid aldopyranoside from soybean tissue.[Pubmed: 16661896 ]

METHODS AND RESULTS:
A previously unidentified abscisic acid metabolite has been isolated and characterized. (+/-)-[2-(14)C]Abscisic acid was incubated in intact soybean leaves and pods; the radiolabeled metabolite was purified by high performance liquid chromatography with on-line scintillation spectrometry detection. Gas chromatography-mass spectrometry was used to obtain spectra of the acetylated and methyl esterified derivatives.
CONCLUSIONS:
The data were consistent with a proposed Dihydrophaseic acid-aldopyranoside identity. Conjugation through the 4'-hydroxyl of Dihydrophaseic acid is suggested.
CFN98414Ascleposide E325686-49-5388.5 C19H32O8
CFN96992Citroside A120330-44-1386.44C19H30O8
CFN96968Icariside B1109062-00-2386.44C19H30O8
CFN98657Dihydrophaseic acid41756-77-8282.3 C15H22O5
CFN95393Dihydrophaseic acid 4'-O-beta-D-glucopyranoside78914-56-4444.5C21H32O10
CFN967418'-Oxo-6-hydroxydihydrophaseic acid1388075-44-2312.31C15H20O7
CFN90051Abscisic acid21293-29-8264.32C15H20O4
CFN953088'-O-(3-hydroxy-3-methylglutaryl)-8'-hydroxyabscisic acid69790-31-4424.4C21H28O9
CFN96810Breyniaionoside A823182-23-6404.45C19H32O9
CFN97498Cucumegastigmane I929881-46-9240.3 C13H20O4
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