Dopamine hydrochloride | CAS:62-31-7 | Manufacturer ChemFaces

Dopamine hydrochloride

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $7.0 / In-stock
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Description:

Dopamine hydrochloride is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.

Targets:

Dopamine Receptor

In vivo:

Am J Vet Res. 2015 Feb;76(2):116-21.

Cardiovascular effects of dopamine hydrochloride and phenylephrine hydrochloride in healthy isoflurane-anesthetized New Zealand White rabbits (Oryctolagus cuniculus).[Pubmed: 25629908]

To determine the cardiopulmonary effects of progressively increasing infusion rates of Dopamine hydrochloride and phenylephrine hydrochloride in healthy adult New Zealand White rabbits anesthetized with isoflurane. ANIMALS: 6 New Zealand White rabbits. (Oryctolagus cuniculus).
METHODS AND RESULTS:
Each rabbit was anesthetized on 2 occasions (≥ 2 weeks apart) with isoflurane in oxygen at 1.5 times the published isoflurane minimum alveolar concentration of 2.07%. Carotid artery and pulmonary artery catheters were placed. During each anesthetic episode, each rabbit received 5 progressively increasing doses of either dopamine (5, 10, 15, 20, or 30 μg/kg/min) or phenylephrine (0.125, 0.25, 0.5, 1.0, and 2.0 μg/kg/min). Blood gas and cardiopulmonary measurements were obtained after a 20-minute equilibration period prior to administration of the first drug dose (baseline) and after each subsequent dose administration. Dopamine increased stroke index at the highest infusion rate of 30 μg/kg/min; however, cardiac output and mean arterial blood pressure remained unchanged from baseline values. Administration of phenylephrine at a rate of 2 μg/kg/min increased mean arterial blood pressure to 62 mm Hg from the baseline value of 45 mm Hg. This was a result of an increase in systemic vascular resistance with a concomitant decrease in heart rate and no change in cardiac output. Blood lactate concentration increased with time when rabbits received either treatment.
CONCLUSIONS:
Within the dose range of 5 to 30 μg/kg/min, dopamine was not an effective treatment for isoflurane-induced hypotension in rabbits and phenylephrine was only minimally effective at a dose of 2 μg/kg/min.

Dopamine hydrochloride Description

Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

J Chem Phys. 2015 Jan 7;142(1):014502.

Conformation and interactions of dopamine hydrochloride in solution.[Pubmed: 25573567]

METHODS AND RESULTS:
The aqueous solution of Dopamine hydrochloride has been investigated using neutron and X-ray total scattering data together with Monte-Carlo based modelling using Empirical Potential Structure Refinement. The conformation of the protonated dopamine molecule is presented and the results compared to the conformations found in crystal structures, dopamine-complexed protein crystal structures and predicted from theoretical calculations and pharmacophoric models. It is found that protonated dopamine adopts a range of conformations in solution, highlighting the low rotational energy barrier between different conformations, with the preferred conformation being trans-perpendicular.
CONCLUSIONS:
The interactions between each of the species present (protonated dopamine molecules, water molecules, and chloride anions) have been determined and are discussed with reference to interactions observed in similar systems both in the liquid and crystalline state, and predicted from theoretical calculations. The expected strong hydrogen bonds between the strong hydrogen bond donors and acceptors are observed, together with evidence of weaker CH hydrogen bonds and π interactions also playing a significant role in determining the arrangement of adjacent molecules.

Product Name	Dopamine hydrochloride
Price:	$30 / 20mg
CAS No.:	62-31-7
Catalog No.:	CFN90036
Molecular Formula:	C₈H₁₁NO₂
Molecular Weight:	153.18 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	White powder
Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library Dopamine Receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.5283 mL	32.6413 mL	65.2827 mL	130.5653 mL	163.2067 mL
5 mM	1.3057 mL	6.5283 mL	13.0565 mL	26.1131 mL	32.6413 mL
10 mM	0.6528 mL	3.2641 mL	6.5283 mL	13.0565 mL	16.3207 mL
50 mM	0.1306 mL	0.6528 mL	1.3057 mL	2.6113 mL	3.2641 mL
100 mM	0.0653 mL	0.3264 mL	0.6528 mL	1.3057 mL	1.6321 mL

CFN90036	Dopamine hydrochloride	62-31-7	153.18	C₈H₁₁NO₂
CFN90032	Adrenaline	51-43-4	183.2	C₉H₁₃NO₃
CFN90047	Norepinephrine	51-41-2	169.18	C₈H₁₁NO₃
CFN94011	3-Hydroxy-2-phenyl-propanamide	56598-62-0	165.19	C₉H₁₁NO₂
CFN98187	2-(Acetylamino)-3-phenyl-2-propenoic acid	5469-45-4	205.21	C₁₁H₁₁NO₃
CFN99551	Synephrine	94-07-5	167.21	C₉H₁₃NO₂
CFN99901	Hordenine	539-15-1	165.24	C₁₀H₁₅NO
CFN91816	Candicine	6656-13-9	180.3	C₁₁H₁₈NO
CFN91803	Coryneine	7224-66-0	196.3	C₁₁H₁₈NO₂
CFN94479	Procaine	59-46-1	236.31	C₁₃H₂₀N₂O₂