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Europine
Europine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Europine
Price:
CAS No.: 570-19-4
Catalog No.: CFN00264
Molecular Formula: C16H27NO6
Molecular Weight: 329.39 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Cynoglossum officinale L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Europine shows both antifungal and insect antifeedant activity.
Targets: Antifection
In vivo:
Vet Hum Toxicol. 2003 Aug;45(4):198-201.
Toxicity of dietary Heliotropium circinatum to rats.[Pubmed: 12882490]

METHODS AND RESULTS:
Pyrrolizidine alkaloid intoxication was produced in adult, male rats by feeding different levels (0, 1, 3, 5 or 10%) of Heliotropium circinatum for 20 w. Combined GC-MS revealed 0.15% total alkaloid content in the plant material of which 12% and 88% were basic and N-oxide forms, respectively. The specific alkaloids identified were Europine (67.33%), heliotrine (16.34%), lasiocarpine (8.12%), heleurine (4.18%), echinatine (1.56%), 7-angeylheliotrine (1.19%), and an unknown alkaloid (1.28%). Neither mortality nor significant clinical changes occurred in test groups. Mild to moderate, dose-related hepatic megalocytosis was the most prominent histopathological finding. In addition to chronic hepatotoxicity, notable medial thickening occurred in the pulmonary arterioles and arteries of the high-dosed groups.
CONCLUSIONS:
This study indicated that H. circinatum plant has limited toxic potential in rats with mild to moderate histological changes and no mortality at the dosing levels, total doses, or time of exposure employed.
Europine Description
Source: The herbs of Cynoglossum officinale L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0359 mL 15.1796 mL 30.3591 mL 60.7183 mL 75.8979 mL
5 mM 0.6072 mL 3.0359 mL 6.0718 mL 12.1437 mL 15.1796 mL
10 mM 0.3036 mL 1.518 mL 3.0359 mL 6.0718 mL 7.5898 mL
50 mM 0.0607 mL 0.3036 mL 0.6072 mL 1.2144 mL 1.518 mL
100 mM 0.0304 mL 0.1518 mL 0.3036 mL 0.6072 mL 0.759 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Phytochemistry,1995,38( 2):355-8.
Pyrrolizidine alkaloids from Heliotropium bovei[Reference: WebLink]

METHODS AND RESULTS:
Heliotropium bovei was shown to contain lasiocarpine, Europine, 5′-acetyllasiocarpine and a new alkaloid 7-acetylEuropine. Lasiocarpine N-oxide and 5′-acetyllasiocarpine N-oxide are also present in this plant species.
CONCLUSIONS:
These structures were established from spectral and chemical studies including 2D NMR. Europine showed both antifungal and insect antifeedant activity, while 7-acetylEuropine was inactive.
Oleocanthal

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Bacopaside II

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Carlinoside

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Eurycomanone

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Alisol O

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Geniposide

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Shuterin

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Catalpol

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