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Episesartemin A
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Product Name Episesartemin A
Price:
CAS No.: 77449-31-1
Catalog No.: CFN96936
Molecular Formula: C23H26O8
Molecular Weight: 430.45 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The roots of Artemisia absinthium.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Episesartemin A is a natural product from Artemisia absinthium.
In vitro:
Phytochemistry. 2017 Mar;135:181-190.
Sensory active piperine analogues from Macropiper excelsum and their effects on intestinal nutrient uptake in Caco-2 cells.[Pubmed: 28065397]
The phytochemical profile of Macropiper excelsum (G.Forst.) Miq. subsp. excelsum (Piperaceae), a shrub which is widespread in New Zealand, was investigated by LC-MS-guided isolation and characterization via HR-ESI-TOF-MS and NMR spectroscopy.
METHODS AND RESULTS:
The isolated compounds were sensorily evaluated to identify their contribution to the overall taste of the crude extract with sweet, bitter, herbal and trigeminal impressions. Besides the known non-volatile Macropiper compounds, the lignans (+)-diayangambin and (+)-excelsin, four further excelsin isomers, (+)-diasesartemin, (+)-sesartemin, (+)-Episesartemin A and episesartemin B were newly characterized. Moreover, piperine and a number of piperine analogues as well as trans-pellitorine and two homologues, kalecide and (2E,4E)-tetradecadienoic acid N-isobutyl amide were identified in M. excelsum, some of them for the first time.
Episesartemin A Description
Source: The roots of Artemisia absinthium.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3232 mL 11.6158 mL 23.2315 mL 46.463 mL 58.0788 mL
5 mM 0.4646 mL 2.3232 mL 4.6463 mL 9.2926 mL 11.6158 mL
10 mM 0.2323 mL 1.1616 mL 2.3232 mL 4.6463 mL 5.8079 mL
50 mM 0.0465 mL 0.2323 mL 0.4646 mL 0.9293 mL 1.1616 mL
100 mM 0.0232 mL 0.1162 mL 0.2323 mL 0.4646 mL 0.5808 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Tetrahedron, 1980, 36(24):3551-3558.
New unsymmetrically substituted tetrahydrofurofuran lignans from artemisia absinthium: Assignment of the relative stereochemistry by lanthanide induced chemical shifts.[Reference: WebLink]
The isolation of thirteen tetrahydrofurofuran lignans from the roots of A. absinthium and six closely related species is reported.
METHODS AND RESULTS:
A new group of four lignans, all stereoisomers of 1- [(3,4-methylenedioxy-5-methoxy) phenyl]-4-(3,4,5-trimethoxyphenyl)-tetrahydro-1H,3H-furo[3,4-c]furan, was found. The compounds, named sesartemin, Episesartemin A, episesartemin B, and diasesartemin, were characterized by 1H NMR (including lanthanide induced shifts), UV, IR and MS.
CONCLUSIONS:
A fifth new lignan of the sesamin type (the eq/eq isomer of fargesin) could be identified as a minor constituent. The relative configurations of two further products (fargesin and epiashantin) could be confirmed by the lanthanide induced shift technique.
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