Ermanin | CAS:20869-95-8 | Manufacturer ChemFaces

Ermanin

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $203.3 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Senecionine

Catalog No: CFN00417
CAS No: 130-01-8
Price: $ /

Proanthocyanidins

Catalog No: CFN99556
CAS No: 4852-22-6
Price: $70/20mg

Phloretin

Catalog No: CFN97040
CAS No: 60-82-2
Price: $40/20mg

Soyasaponin Aa

Catalog No: CFN90455
CAS No: 117230-33-8
Price: $ / mg

Aurantio-obtusin

Catalog No: CFN99732
CAS No: 67979-25-3
Price: $90/20mg

Pinostrobin chalcone

Catalog No: CFN99878
CAS No: 18956-15-5
Price: $368/20mg

Tetramethylpyrazine

Catalog No: CFN99909
CAS No: 1124-11-4
Price: $30/20mg

Aloenin A

Catalog No: CFN93235
CAS No: 38412-46-3
Price: $ / mg

Orientin

Catalog No: CFN98136
CAS No: 28608-75-5
Price: $70/20mg

Obtusifolin

Catalog No: CFN90394
CAS No: 477-85-0
Price: $268/20mg

Description:

Ermanin shows anti-inflammatory activity by suppressing the iNOS and COX-2 expression. Ermanin may have anti-HIV-1activity. Ermanin also has a high deterrent activity at 40 ppm against Dione juno larvae.

Targets:

NO | PGE | NOS | COX | HIV | Antifection

In vitro:

Planta Med. 2010 May;76(7):721-5.

Anti-HIV-1 diterpenoids from leaves and twigs of Polyalthia sclerophylla.[Pubmed: 20013639]

METHODS AND RESULTS:
Bioassay-guided fractionation and purification of the anti-HIV-1-active MeOH extract from the leaves and twigs of Polyalthia sclerophylla led to the isolation of two new compounds, ENT-kaur-sclerodimer ( 1) and cyclotucanol 3-palmitate ( 2), along with the known ENT-kaur-16-en-19-oic acid ( 3), 15 beta-hydroxy- ENT-kaur-16-en-19-oic acid ( 4), 15 beta-acetoxy- ENT-kaur-16-en-19-oic acid ( 5), 15-oxo- ENT-kaur-16-en-19-oic acid ( 6), 16 alpha,17-dihydroxy- ENT-kauran-19-oic acid ( 7), 16 alpha-hydroxy- ENT-kauran-19-oic acid (xylopic acid) ( 8), a pseudodimer (15 alpha-hydroxy- ENT-kaur-16-en-19-oic acid/17-hydroxy- ENT-kaur-15-en-19-oic acid) ( 9), Ermanin, nicotiflorin, and allantoin.
CONCLUSIONS:
Among these isolates, compound 3 was the most active in both anti-syncytium (EC (50) 13.7 microg/mL and selectivity index 3.1) and HIV-1 reverse transcriptase (IC (50) 34.1 microg/mL) assays.

Phytochemistry, 1991, 30(1):153-5.

Ermanin: An insect deterrent flavonoid from Passiflora foetida resin.[Reference: WebLink]

METHODS AND RESULTS:
Ten flavonoids were isolated from Passiflora foetida L. resin. One of them, Ermanin, has a high deterrent activity at 40 ppm against Dione juno larvae.

Ermanin Description

Source:	The herbs of Tanacetum parthenium.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Int Immunopharmacol. 2006 Nov;6(11):1723-8.

Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids isolated from Tanacetum microphyllum.[Pubmed: 16979127]

Plant flavonoids show anti-inflammatory activity both in vitro and in vivo. Some flavonoids have been reported previously to inhibit nitric oxide (NO) and prostaglandin E2 (PGE2) production by suppressing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression.
METHODS AND RESULTS:
The present study focuses on the effect of various naturally occurring flavonoids (santin, Ermanin, centaureidin and 5,3'-dihydroxy-4'-methoxy-7-methoxycarbonylflavonol) on modulation of lipopolysaccharide (LPS)-induced iNOS and COX-2 expression in RAW 264.7 cells. Western blotting showed that all flavonoids suppressed the induction of both iNOS and COX-2. Ermanin and 5,3'-dihydroxy-4'-methoxy-7-methoxycarbonylflavonol were the most potent inhibitors.
CONCLUSIONS:
This study suggests that inhibition of iNOS and COX-2 expression by flavonoids may be one of the mechanisms responsible for their anti-inflammatory effects, and that they may be potential agents for use in the treatment of inflammatory diseases.

Product Name	Ermanin
Price:	$388 / 10mg
CAS No.:	20869-95-8
Catalog No.:	CFN98050
Molecular Formula:	C₁₇H₁₄O₆
Molecular Weight:	314.3 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Source:	The herbs of Tanacetum parthenium.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Insecticides Compound Library Flavonoids Compound Library PGE Inhibitor Library NOS Inhibitor Library NO Inhibitor Library HIV Inhibitor Library COX Inhibitor Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1817 mL	15.9084 mL	31.8167 mL	63.6335 mL	79.5418 mL
5 mM	0.6363 mL	3.1817 mL	6.3633 mL	12.7267 mL	15.9084 mL
10 mM	0.3182 mL	1.5908 mL	3.1817 mL	6.3633 mL	7.9542 mL
50 mM	0.0636 mL	0.3182 mL	0.6363 mL	1.2727 mL	1.5908 mL
100 mM	0.0318 mL	0.1591 mL	0.3182 mL	0.6363 mL	0.7954 mL

CFN93002	Isokaempferide	1592-70-7	300.3	C₁₆H₁₂O₆
CFN92510	Kaempferol 5-methyl ether	22044-80-0	300.3	C₁₆H₁₂O₆
CFN97724	Rhamnocitrin	569-92-6	300.27	C₁₆H₁₂O₆
CFN98782	Kaempferide	491-54-3	300.3	C₁₆H₁₂O₆
CFN98423	Kumatakenin	3301-49-3	314.3	C₁₇H₁₄O₆
CFN99651	3,5-Dihydroxy-4',7-dimethoxyflavone	15486-33-6	314.3	C₁₇H₁₄O₆
CFN98050	Ermanin	20869-95-8	314.3	C₁₇H₁₄O₆
CFN96191	Kaempferol 3,7,4'-trimethylether	15486-34-7	328.3	C₁₈H₁₆O₆
CFN96292	Kaempferol 5,7,4'-trimethyl ether	1098-92-6	328.3	C₁₈H₁₆O₆
CFN91889	Tetramethylkaempferol	16692-52-7	342.34	C₁₉H₁₈O₆