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Ervamycine
Ervamycine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Ervamycine
Price:
CAS No.: 27773-39-3
Catalog No.: CFN98338
Molecular Formula: C22H26N2O3
Molecular Weight: 366.5 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Melodinus khasianus.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 11-Methoxytabersonine(Ervamycine) exhibits inhibitory effects against five human cancer cell lines , with IC(50) values comparable to those of cisplatin and vinorelbine.
In vitro:
J Nat Prod. 2010 Jun 25;73(6):1075-9.
Cytotoxic indole alkaloids from Melodinus tenuicaudatus.[Pubmed: 20462230]

METHODS AND RESULTS:
Four new bisindole alkaloids, melodinines H-K (1-4), a new monomer, melodinine L (5), and 11 known alkaloids were isolated from Melodinus tenuicaudatus. The structures of 1-5 were elucidated by extensive spectroscopic methods, and the known compounds were identified by comparison with data in the literature. All of the compounds were evaluated for their cytotoxicity against five human cancer cell lines.
CONCLUSIONS:
Alkaloids 1, 3, and 4 and the known compound 11-methoxytabersonine (Ervamycine,8) exhibited inhibitory effects, with IC(50) values comparable to those of cisplatin and vinorelbine.
Ervamycine Description
Source: The herbs of Melodinus khasianus.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
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IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
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Nature Plants. 2016 Dec 22;3: 16206.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7285 mL 13.6426 mL 27.2851 mL 54.5703 mL 68.2128 mL
5 mM 0.5457 mL 2.7285 mL 5.457 mL 10.9141 mL 13.6426 mL
10 mM 0.2729 mL 1.3643 mL 2.7285 mL 5.457 mL 6.8213 mL
50 mM 0.0546 mL 0.2729 mL 0.5457 mL 1.0914 mL 1.3643 mL
100 mM 0.0273 mL 0.1364 mL 0.2729 mL 0.5457 mL 0.6821 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN96116Tubotaiwine6711-69-9324.4C20H24N2O2
CFN89178Hecubine62874-52-6310.44C20H26N2O
CFN97570Scholaricine99694-90-3356.4 C20H24N2O4
CFN9820511-Hydroxytabersonine22149-28-6352.4 C21H24N2O3
CFN98338Ervamycine27773-39-3366.5 C22H26N2O3
CFN89194Echitovenidine7222-35-7436.55C26H32N2O4
CFN89203Echitoveniline72855-79-9548.63C31H36N2O7
CFN98799Vandrikidine50656-92-3382.5 C22H26N2O4
CFN98853Vindorosine5231-60-7426.5 C24H30N2O5
CFN98083Vindoline2182-14-1456.5 C25H32N2O6
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