Ervamycine | CAS:27773-39-3 | Manufacturer ChemFaces

Ervamycine

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

11-Methoxytabersonine(Ervamycine) exhibits inhibitory effects against five human cancer cell lines , with IC(50) values comparable to those of cisplatin and vinorelbine.

In vitro:

J Nat Prod. 2010 Jun 25;73(6):1075-9.

Cytotoxic indole alkaloids from Melodinus tenuicaudatus.[Pubmed: 20462230]

METHODS AND RESULTS:
Four new bisindole alkaloids, melodinines H-K (1-4), a new monomer, melodinine L (5), and 11 known alkaloids were isolated from Melodinus tenuicaudatus. The structures of 1-5 were elucidated by extensive spectroscopic methods, and the known compounds were identified by comparison with data in the literature. All of the compounds were evaluated for their cytotoxicity against five human cancer cell lines.
CONCLUSIONS:
Alkaloids 1, 3, and 4 and the known compound 11-methoxytabersonine (Ervamycine,8) exhibited inhibitory effects, with IC(50) values comparable to those of cisplatin and vinorelbine.

Ervamycine Description

Source:	The herbs of Melodinus khasianus.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Ervamycine
Price:
CAS No.:	27773-39-3
Catalog No.:	CFN98338
Molecular Formula:	C₂₂H₂₆N₂O₃
Molecular Weight:	366.5 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Melodinus khasianus.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Cytotoxic Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7285 mL	13.6426 mL	27.2851 mL	54.5703 mL	68.2128 mL
5 mM	0.5457 mL	2.7285 mL	5.457 mL	10.9141 mL	13.6426 mL
10 mM	0.2729 mL	1.3643 mL	2.7285 mL	5.457 mL	6.8213 mL
50 mM	0.0546 mL	0.2729 mL	0.5457 mL	1.0914 mL	1.3643 mL
100 mM	0.0273 mL	0.1364 mL	0.2729 mL	0.5457 mL	0.6821 mL

CFN90926	Vindolinine	5980-02-9	336.43	C₂₁H₂₄N₂O₂
CFN98256	Scandine	24314-59-8	350.4	C₂₁H₂₂N₂O₃
CFN89217	Scandine Nb-oxide	140701-69-5	366.41	C₂₁H₂₂N₂O₄
CFN96730	10-Acetoxyscandine	1432058-90-6	408.45	C₂₃H₂₄N₂O₅
CFN96116	Tubotaiwine	6711-69-9	324.4	C₂₀H₂₄N₂O₂
CFN89178	Hecubine	62874-52-6	310.44	C₂₀H₂₆N₂O
CFN97570	Scholaricine	99694-90-3	356.4	C₂₀H₂₄N₂O₄
CFN98205	11-Hydroxytabersonine	22149-28-6	352.4	C₂₁H₂₄N₂O₃
CFN98338	Ervamycine	27773-39-3	366.5	C₂₂H₂₆N₂O₃
CFN89194	Echitovenidine	7222-35-7	436.55	C₂₆H₃₂N₂O₄