Esculentoside H | CAS:66656-92-6 | Manufacturer ChemFaces

Esculentoside H

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Description:

Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.

Targets:

TNF-α

In vitro:

Zhongguo Yao Li Xue Bao. 1993 Nov;14(6):550-2.

Effect of esculentoside H on release of tumor necrosis factor from mouse peritoneal macrophages.[Pubmed: 8010057]

METHODS AND RESULTS:
Effect of Esculentoside H (EH) on release of tumor necrosis factor (TNF) from murine peritoneal macrophage (Mphi) in vitro was studied. The results showed that Esculentoside H (12.5-200 micrograms.ml-1) induced the thioglycolate-broth elicited peritoneal Mphi to release TNF into supernatants in a dose-dependent manner, and higher levels of TNF activity were detected in the supernatants from Esculentoside H-stimulated calcimycin-primed Mø culture. Esculentoside H-induced TNF release had a different type of kinetics compared with that of lipopolysaccharides (LPS). LPS-induced release of TNF increased rapidly until 6 h after LPS stimulation, then declined gradually, while Esculentoside H-induced TNF release increased gradually after Esculentoside H stimulation and reached its peak at approximately 24 h later.
CONCLUSIONS:
These results suggested that the anti-tumor mechanisms of Phytolaccaceae may be related to the capacity of Esculentoside H for TNF release.

Esculentoside H Description

Source:	The roots of Phytolacca acinosa Roxb.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Esculentoside H
Price:	$138 / 20mg
CAS No.:	66656-92-6
Catalog No.:	CFN90657
Molecular Formula:	C₄₈H₇₆O₂₁
Molecular Weight:	989.1 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The roots of Phytolacca acinosa Roxb.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Triterpenoids Compound Library TNF-α Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.011 mL	5.0551 mL	10.1102 mL	20.2204 mL	25.2755 mL
5 mM	0.2022 mL	1.011 mL	2.022 mL	4.0441 mL	5.0551 mL
10 mM	0.1011 mL	0.5055 mL	1.011 mL	2.022 mL	2.5276 mL
50 mM	0.0202 mL	0.1011 mL	0.2022 mL	0.4044 mL	0.5055 mL
100 mM	0.0101 mL	0.0506 mL	0.1011 mL	0.2022 mL	0.2528 mL

CFN92914	24-Hydroxy-licoricesaponin A3	1262326-47-5	1001.07	C₄₈H₇₂O₂₂
CFN92912	Licoricesaponin E2	119417-96-8	820.92	C₄₂H₆₀O₁₆
CFN92913	Uralsaponin D	1262489-44-0	850.90	C₄₂H₅₈O₁₈
CFN92924	Uralsaponin C	1262326-46-4	824.95	C₄₂H₆₄O₁₆
CFN98163	Esculentoside B	60820-94-2	664.82	C₃₆H₅₆O₁₁
CFN98165	Esculentoside D	89808-50-4	694.85	C₃₇H₅₈O₁₂
CFN98164	Esculentoside C	65931-92-2	810.97	C₄₂H₆₆O₁₅
CFN98162	Esculentoside A	65497-07-6	826.96	C₄₂H₆₆O₁₆
CFN90657	Esculentoside H	66656-92-6	989.1	C₄₈H₇₆O₂₁
CFN90658	Esculentoside T	N/A	824.4	C₄₂H₆₄O₁₆