Cannabisin B | CAS:144506-17-2 | Manufacturer ChemFaces

Cannabisin B

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Description:

Cannabisin B possesses considerable antiproliferative activity and that it may be utilised as a promising chemopreventive agent against hepatoblastoma disease. It induces autophagic cell death by inhibiting the AKT/mTOR pathway and S phase cell cycle arrest in HepG2 cell.

Targets:

Akt | mTOR

In vitro:

Food Chemistry, 2013,138(2-3):1034-41.

Cannabisin B induces autophagic cell death by inhibiting the AKT/mTOR pathway and S phase cell cycle arrest in HepG2 cells.[Reference: WebLink]

METHODS AND RESULTS:
This study investigates the anticancer properties of Cannabisin B, purified from hempseed hull, in HepG2 human hepatoblastoma cells. The results indicate that Cannabisin B significantly inhibited cell proliferation by inducing autophagic cell death rather than typical apoptosis. Cell viability transiently increased upon the addition of a low concentration of Cannabisin B but decreased upon the addition of high concentrations. Cannabisin B-induced changes in cell viability were completely inhibited by pre-treatment with 3-methyladenine (3-MA), indicating that the induction of autophagy by Cannabisin B caused cell death. Additionally, Cannabisin B induced S phase cell cycle arrest in a dose-dependent manner. Moreover, Cannabisin B was found to inhibit survival signaling by blocking the activation of AKT and down-stream targets of the mammalian target of rapamycin (mTOR).
CONCLUSIONS:
These findings suggest that Cannabisin B possesses considerable antiproliferative activity and that it may be utilised as a promising chemopreventive agent against hepatoblastoma disease.

Cannabisin B Description

Source:	The herbs of Cannabis sativa L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Cannabisin B
Price:	$413 / 5mg
CAS No.:	144506-17-2
Catalog No.:	CFN95268
Molecular Formula:	C₃₄H₃₂N₂O₈
Molecular Weight:	596.6 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Cannabis sativa L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library mTOR Inhibitor Library Akt Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6762 mL	8.3808 mL	16.7616 mL	33.5233 mL	41.9041 mL
5 mM	0.3352 mL	1.6762 mL	3.3523 mL	6.7047 mL	8.3808 mL
10 mM	0.1676 mL	0.8381 mL	1.6762 mL	3.3523 mL	4.1904 mL
50 mM	0.0335 mL	0.1676 mL	0.3352 mL	0.6705 mL	0.8381 mL
100 mM	0.0168 mL	0.0838 mL	0.1676 mL	0.3352 mL	0.419 mL

CFN92966	Tamgermanetin	640235-90-1	313.35	C₁₈H₁₉NO₄
CFN92826	Cis-N-Feruloyltyramine	80510-09-4	313.4	C₁₈H₁₉NO₄
CFN97707	N-Feruloyloctopamine	66648-44-0	329.35	C₁₈H₁₉NO₅
CFN95768	cis-N-Feruloyloctopamine	180050-83-3	329.4	C₁₈H₁₉NO₅
CFN97809	Cannabisin F	163136-19-4	624.69	C₃₆H₃₆N₂O₈
CFN95286	Lyciumamide B	1647111-41-8	624.7	C₃₆H₃₆N₂O₈
CFN94001	Cannabisin H	403647-08-5	509.55	C₂₈H₃₁NO₈
CFN93215	Kukoamine A	75288-96-9	530.7	C₂₈H₄₂N₄O₆
CFN93216	Kukoamine B	164991-67-7	530.7	C₂₈H₄₂N₄O₆
CFN98937	Asperglaucide	56121-42-7	444.5	C₂₇H₂₈N₂O₄