Eupalinolide I | CAS:1402067-84-8 | Manufacturer ChemFaces

Eupalinolide I

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Description:

Eupalinolide I is a natural product from Eupatorium lindleyanum.

Targets:

STAT

In vitro:

Nat Prod Res. 2017 Oct 31:1-9.

Precise discovery of a STAT3 inhibitor from Eupatorium lindleyanum and evaluation of its activity of anti-triple-negative breast cancer.[Pubmed: 29086600]

Michael reaction acceptors (MRAs) are a class of active compounds. There is a great prospect to screen STAT3 inhibitors from Eupatorium lindleyanum, furthermore, to discover lead compounds for anti-triple-negative breast cancer (TNBC).
METHODS AND RESULTS:
In this study, glutathione (GSH) was employed, and a UPLC-MS screening method was developed to discover MRAs. We screened MRAs which can inhibit STAT3 using a STAT3-dependent reporter system. Six sesquiterpene lactones, including a new compound Eupalinolide O (1), together with five known compounds, Eupalinolide I (2), Eupalinolide K (3), Eupalinolide H (4), Eupalinolide J (5) and Eupalinolide G (6) were isolated. Eupalinolide J was identified as MRA that decreased luciferase activity of STAT3.
CONCLUSIONS:
Preliminary activity assessment showed that Eupalinolide J could inhibit the viability of TNBC cell lines. We demonstrated that Eupalinolide J, which is a natural typical MRA, has a notable inhibition of STAT3 activity and a potential cytotoxic activity against TNBC cell lines.

Eupalinolide I Description

Source:	The aerial plants of Eupatorium lindleyanum.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Eupalinolide I
Price:
CAS No.:	1402067-84-8
Catalog No.:	CFN89073
Molecular Formula:	C₂₄H₃₀O₉
Molecular Weight:	462.49 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Oil
Source:	The aerial plants of Eupatorium lindleyanum.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Sesquiterpenoids Compound Library STAT Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1622 mL	10.811 mL	21.6221 mL	43.2442 mL	54.0552 mL
5 mM	0.4324 mL	2.1622 mL	4.3244 mL	8.6488 mL	10.811 mL
10 mM	0.2162 mL	1.0811 mL	2.1622 mL	4.3244 mL	5.4055 mL
50 mM	0.0432 mL	0.2162 mL	0.4324 mL	0.8649 mL	1.0811 mL
100 mM	0.0216 mL	0.1081 mL	0.2162 mL	0.4324 mL	0.5406 mL

CFN89039	2alpha-Hydroxyeupatolide 8-O-angelate	72229-39-1	346.42	C₂₀H₂₆O₅
CFN96924	Deacetyleupaserrin	38456-39-2	362.42	C₂₀H₂₆O₆
CFN96933	Mollisorin A	72704-04-2	346.42	C₂₀H₂₆O₅
CFN89018	2alpha-Hydroxy-8beta-(2-methylbutyryloxy)costunolide	128286-87-3	348.43	C₂₀H₂₈O₅
CFN89040	Chromolaenide	66148-25-2	404.45	C₂₂H₂₈O₇
CFN96938	3-Epichromolaenide	89913-53-1	404.45	C₂₂H₂₈O₇
CFN96960	4E-Deacetylchromolaenide 4'-O-acetate	104736-09-6	404.45	C₂₂H₂₈O₇
CFN96916	Eucannabinolide	38458-58-1	420.45	C₂₂H₂₈O₈
CFN96931	Eupahualin C	108525-39-9	360.40	C₂₀H₂₄O₆
CFN89073	Eupalinolide I	1402067-84-8	462.49	C₂₄H₃₀O₉