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Flavanomarein
Flavanomarein
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Flavanomarein
Price: $358 / 5mg
CAS No.: 577-38-8
Catalog No.: CFN91006
Molecular Formula: C21H22O11
Molecular Weight: 450.4 g/mol
Purity: >=98%
Type of Compound: Chalcones
Physical Desc.: Powder
Source: The herbs of Laurentia atropurpurea
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $318 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Flavanomarein demonstrates potent antioxidative property, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid‑lowering effects in human HepG2 hepatocellular carcinoma cells treated with free fatty acids (FFAs).
In vitro:
Mol Med Rep. 2017 Aug;16(2):1298-1306.
Eriodictyol 7‑O‑β‑D glucopyranoside from Coreopsis tinctoria Nutt. ameliorates lipid disorders via protecting mitochondrial function and suppressing lipogenesis.[Pubmed: 28627652]
Coreopsis tinctoria (snow chrysanthemum) has been reported to exert antihyperlipidemic effects.
METHODS AND RESULTS:
The present study aimed to identify the active compounds of Coreopsis tinctoria and to investigate the molecular mechanisms underlying its effects on lipid dysregulation by measuring lipid levels, reactive oxygen species, lipid peroxidation and fatty acid synthesis. The present results demonstrated that snow chrysanthemum aqueous extracts significantly reduced serum lipid levels and oxidative stress in vivo. The main compounds that were isolated were identified as Flavanomarein (compound 1) and eriodictyol 7‑O‑β‑D glucopyranoside (compound 2). Compounds 1 and 2 demonstrated potent antioxidative properties, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid‑lowering effects in human HepG2 hepatocellular carcinoma cells treated with free fatty acids (FFAs). Compound 2 was revealed to suppress the elevation of triglyceride levels and inhibit lipid peroxidation following FFA treatment. In addition, it was demonstrated to significantly reduce intracellular levels of reactive oxygen species and improve the mitochondrial membrane potential and adenosine triphosphate levels, thus protecting mitochondrial function in FFA‑treated HepG2 cells. Furthermore, compound 2 markedly suppressed the protein expression levels of disulfide‑isomerase A3 precursor and fatty acid synthase, thus suppressing FFA‑induced lipogenesis in HepG2 cells.
CONCLUSIONS:
In conclusion, the present study identified compound 2 as one of the main active compounds in Coreopsis tinctoria responsible for its lipid‑lowering effects. Compound 2 was revealed to possess antihyperlipidemic properties, exerted via reducing oxidative stress, protecting mitochondrial function and suppressing lipogenesis.
Acta Pol Pharm. 2007 Sep-Oct;64(5):441-7.
Antioxidant activity of extracts and flavonoids from Bidens tripartita.[Pubmed: 18540165]
Extracts from herb and flowers of Bidens tripartita L. (Asteraceae), obtained using solvents of different polarity, were studied for their radical scavenging effects.
METHODS AND RESULTS:
Antioxidant activities of pure flavonoids: Flavanomarein (isookanin 7-O-glucoside), cynaroside (luteolin 7-O-glucoside) and luteolin, which had been isolated from this plant, were also evaluated. Radical-scavenging activity was measured by electron paramagnetic resonance (EPR) spectroscopy using stable 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. The content of flavonoids in flower heads is half of that found in the herb; however, the extract from flowers showed that the antioxidant activity was almost two times higher there. Some extracts (n-BuOH fraction) showed long lasting radical scavenging activity and the EPR spectra were recorded in time to follow the reaction kinetics.
CONCLUSIONS:
Scavenging of DPPH showed second-order kinetics at the beginning of the assay period and later the first-order one. Different kinetics suggested the presence of polymerized and/or less active antioxidants with different scavenging mechanisms for particular polyphenolic compounds. Bur-marigold extracts are a potential source of natural antioxidants that may be used in pharmaceutical or food industry.
Flavanomarein Description
Source: The herbs of Laurentia atropurpurea
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
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IF=13.903(2019)

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Nature Plants. 2016 Dec 22;3: 16206.
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IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2202 mL 11.1012 mL 22.2025 mL 44.405 mL 55.5062 mL
5 mM 0.444 mL 2.2202 mL 4.4405 mL 8.881 mL 11.1012 mL
10 mM 0.222 mL 1.1101 mL 2.2202 mL 4.4405 mL 5.5506 mL
50 mM 0.0444 mL 0.222 mL 0.444 mL 0.8881 mL 1.1101 mL
100 mM 0.0222 mL 0.111 mL 0.222 mL 0.444 mL 0.5551 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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