(+/-)-Forbesione | CAS:667914-50-3 | Manufacturer ChemFaces

(+/-)-Forbesione

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Apigenin-7-glucuronide

Catalog No: CFN98500
CAS No: 29741-09-1
Price: $80/20mg

Spinosin

Catalog No: CFN99600
CAS No: 72063-39-9
Price: $80/20mg

epsilon-Viniferin

Catalog No: CFN97067
CAS No: 62218-08-0
Price: $338/10mg

Chebulinic acid

Catalog No: CFN92296
CAS No: 18942-26-2
Price: $138/20mg

Juglanin

Catalog No: CFN96238
CAS No: 5041-67-8
Price: $318/5mg

Nodakenin

Catalog No: CFN90232
CAS No: 495-31-8
Price: $70/20mg

Notoginsenoside R1

Catalog No: CFN99999
CAS No: 80418-24-2
Price: $50/20mg

Cyclocurcumin

Catalog No: CFN95103
CAS No: 153127-42-5
Price: $338/10mg

Poricoic acid A(F)

Catalog No: CFN92838
CAS No: 137551-38-3
Price: $218/20mg

Deoxypodophyllotoxin

Catalog No: CFN99888
CAS No: 19186-35-7
Price: $268/10mg

Description:

Forbesione exhibits anti-HIV-1 activity. Forbesione also has antitumor effects, it combined with 5-FU strongly induced apoptosis in Ham-1 cells.

Targets:

Bcl-2/Bax | Caspase | p53 | p65 | NF-kB | IkB | HIV | IKK

In vitro:

Planta Med. 2007 Jan;73(1):33-40.

Cytotoxic and anti-HIV-1 caged xanthones from the resin and fruits of Garcinia hanburyi.[Pubmed: 17117343 ]

Three new caged xanthones, 7-methoxydesoxymorellin (1), 2-isoprenylforbesione (2) and 8,8a-epoxymorellic acid (3), together with nine known caged xanthones were isolated from the EtOAc extracts of resin and fruits of Garcinia hanburyi.
METHODS AND RESULTS:
The structures were determined by spectroscopic methods. Most of the isolated compounds showed significant cytotoxicities against a panel of mammalian cancer cell lines. Compound 3, together with the known compounds desoxymorellin, morellic acid, gambogic acid, hanburin, forbesione and dihydroisomorellin, exhibited anti-HIV-1 activity in the reverse transcriptase (RT) assay while the known compounds desoxygambogenin and dihydroisomorellin were found moderately active in the syncytium assay.
CONCLUSIONS:
This work represents the first report on the anti-HIV-1 activities of caged xanthones.

In vivo:

Asian Pac J Cancer Prev. 2017 Dec 29;18(12):3343-3351.

Synergistic Effect of Forbesione From Garcinia hanburyi in Combination with 5-Fluorouracil on Cholangiocarcinoma[Pubmed: 29286229 ]

Chemotherapy for advanced cholangiocarcinoma (CCA) is largely ineffective; thus innovative combinations of chemotherapeutic agents and natural compounds represent a promising strategy. This study aimed to investigate the synergistic effects of forbesione combined with 5-fluorouracil (5-FU) in hamster cholangiocarcinoma (Ham-1) cells both in vitro and in vivo.
METHODS AND RESULTS:
The anti-tumor effects of 5-FU combined with forbesione in vitro were determined using the Sulforhodamine B (SRB) assay and the effects in vivo were assessed in transplanted Ham-1 allograph models. Using ethidium bromide/acridine orange (EB/AO) staining, the morphological changes of apoptotic cells was investigated. The expressions of apoptosis-related molecules after combined treatment with forbesione and 5-FU were determined using real-time RT-PCR and western blot analysis. Forbesione or 5-FU alone inhibited proliferation of Ham-1 cells in a dose-dependent manner and their combination showed a synergistic proliferation inhibitory effect in vitro. In vivo studies, forbesione in combination with 5-FU exhibited greater inhibition of the tumor in the hamster model compared with treatment using either drug alone. Forbesione combined with 5-FU exerted stronger apoptotic induction in Ham-1 cells than did single drug treatment. The combination of drugs strongly suppressed the expression of B-cell lymphoma 2 (Bcl-2) and procaspase-3 while enhancing the expression of p53, Bcl-2-associated X protein (Bax), apoptotic protease activating factor-1 (Apaf-1), caspase-9 and caspase-3, compared with single drug treatments. These results explained the decreased expression of cytokeratin 19 (CK19) positive cells and proliferation cell nuclear antigen (PCNA) positive cells in Ham-1 cell tumor tissues of the treated hamsters. There was no apparent systemic toxicity observed in the treated animals compared with the control groups. Forbesione combined with 5-FU strongly induced apoptosis in Ham-1 cells.
CONCLUSIONS:
The growth inhibitory effect of combined treatment using these two drugs was much greater than treatment with either drug alone, both in vitro and in vivo.

(+/-)-Forbesione Description

Source:	The herbs of Garcinia hanburyi Hook. f.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

Cancer Cell Int. 2014 Oct 24;14:68.

Synergistic effects of isomorellin and forbesione with doxorubicin on apoptosis induction in human cholangiocarcinoma cell lines.[Pubmed: 25866479 ]

Chemotherapy for advanced cholangiocarcinoma (CCA) is largely ineffective, but innovative combinations of chemotherapeutic agents and natural compounds represent a promising strategy. In our previous studies, isomorellin and forbesione, caged xanthones isolated from Garcinia hanburyi, were found to induce cell cycle arrest and apoptosis in CCA cell lines. The subject of our inquiry is the synergistic effect(s) of these caged xanthones with doxorubicin on growth inhibition and apoptosis induction in human CCA cell lines.
METHODS AND RESULTS:
KKU-100, KKU-M139 and KKU-M156 cell lines and Chang cells were treated with either isomorellin or forbesione alone or in combination with doxorubicin. Cell viability was determined using the sulforhodamine B assay. The combined effects of plant compounds with doxorubicin were analyzed using the isobologram and combination index method of Chou-Talalay. Apoptosis was determined by ethidium bromide/acridine orange staining. Protein expressions were determined by Western blot analysis. Isomorellin or forbesione alone inhibited the growth of these CCA cell lines in a dose-dependent manner and showed selective cytotoxicity against CCA cells but not against Chang cells. Isomorellin/doxorubicin combination showed a synergistic growth inhibitory effect on KKU-M139 and KKU-M156 cells, while the forbesione/doxorubicin combination showed a synergistic growth inhibitory effect on KKU-100 and KKU-M139 cells. The percentages of apoptotic cells were significantly higher in the combined treatments than in the respective single drug treatments. The combined treatments strongly enhanced the expression of Bax/Bcl-2, activated caspase-9 and caspase-3, while suppressing the expression of survivin, procaspase-9 and procaspase-3, compared with single drug treatments. The degree of suppression of NF-κB activation mediated by a decrease in the expression of NF-κB/p65, a reduction of the pIκB-α level and an increase in the IκB-α protein level, was significantly higher in the combined treatment groups than in the single drug treatment groups. The degree of suppression of MRP1 protein expression was also significantly higher in the combined treatment than in the single drug treatment groups.
CONCLUSIONS:
The combinations of isomorellin/doxorubicin and forbesione/doxorubicin showed significant synergistic effects on the growth inhibition and apoptosis induction in KKU-M156 and KKU-100 cells. Caged xanthones may be useful adjunct treatments with chemotherapy for Opisthorchis viverrini (OV)-associated CCA.

Product Name	(+/-)-Forbesione
Price:
CAS No.:	667914-50-3
Catalog No.:	CFN92958
Molecular Formula:	C₂₈H₃₂O₆
Molecular Weight:	464.55 g/mol
Purity:	>=98%
Type of Compound:	Miscellaneous
Physical Desc.:	Powder
Source:	The herbs of Garcinia hanburyi Hook. f.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Miscellaneous Compound Library p65 Inhibitor Library p53 Inhibitor Library NF-kB Inhibitor Library IKK Inhibitor Library IkB Inhibitor Library HIV Inhibitor Library Caspase Inhibitor Library Bcl-2/Bax Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1526 mL	10.7631 mL	21.5262 mL	43.0524 mL	53.8155 mL
5 mM	0.4305 mL	2.1526 mL	4.3052 mL	8.6105 mL	10.7631 mL
10 mM	0.2153 mL	1.0763 mL	2.1526 mL	4.3052 mL	5.3816 mL
50 mM	0.0431 mL	0.2153 mL	0.4305 mL	0.861 mL	1.0763 mL
100 mM	0.0215 mL	0.1076 mL	0.2153 mL	0.4305 mL	0.5382 mL

CFN90172	Gambogic acid	2752-65-0	628.75	C₃₈H₄₄O₈
CFN90175	Neogambogic acid	93772-31-7	646.77	C₃₈H₄₆O₉
CFN95440	Isogambogic acid	149655-52-7	628.8	C₃₈H₄₄O₈
CFN92089	Gambogin	173792-67-1	598.8	C₃₈H₄₆O₆
CFN92098	Epigambogic acid	887606-04-4	628.8	C₃₈H₄₄O₈
CFN92101	30-Hydroxygambogic acid	881027-36-7	644.8	C₃₈H₄₄O₉
CFN92099	9R-10alpha-Hydroxyepigambogic acid	1097882-33-1	646.8	C₃₈H₄₆O₉
CFN92100	10alpha-Hydroxyepigambogic acid	1164201-85-7	646.8	C₃₈H₄₆O₉
CFN95439	Gambogoic acid A	887923-49-1	660.8	C₃₉H₄₈O₉
CFN92957	Gambogoic acid B	887923-50-4	674.82	C₄₀H₅₀O₉