| In vitro: |
| Phytomedicine. 2003;10(6-7):490-3. | | Trypanocidal activity of Lychnophora staavioides Mart. (Vernonieae, Asteraceae).[Pubmed: 13678232] |
METHODS AND RESULTS:
In the continuing search for new compounds with trypanocidal activity for use in blood banks to prevent the transmission of Chagas' disease, a trypanocidal extract of Lychnophora staavioides Mart. (Vernonieae, Asteraceae) was fractionated using several chromatographic techniques and afforded the following flavonoids: tectochrysin, pinostrobin, pinobanksin, pinobanksin 3-acetate, pinocembrin, chrysin, Galangin 3-methyl ether, quercetin 3-methyl ether, chrysoeriol and vicenin-2.
CONCLUSIONS:
The most active compound was quercetin 3-methyl ether, which showed no blood lysis activity and which represents a promising compound for use against T. cruzi in blood banks. | | Z Naturforsch C. 2009 Jul-Aug;64(7-8):509-12. | | Bioactivity of flavonoids isolated from Lychnophora markgravii against Leishmania amazonensis amastigotes.[Pubmed: 19791501] |
METHODS AND RESULTS:
The bioactivity of the flavonoids pinostrobin (1), pinocembrin (2), tectochrysin (3), Galangin 3-methyl ether (4), and tiliroside (5) isolated from Lychnophora markgravii aerial parts was investigated in vitro against amastigote stages of Leishmania amazonensis. The compounds were isolated by several chromatographic techniques and their chemical structures were established by ESI-MS and NMR spectroscopic data.
CONCLUSIONS:
The flavonoids 1 and 3 were the most active compounds; they markedly reduced the viability of Leishmania amastigotes. |
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