Ganoderal A | CAS:104700-98-3 | Manufacturer ChemFaces

Ganoderal A

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Product Name	Ganoderal A
Price:	$488 / 5mg
CAS No.:	104700-98-3
Catalog No.:	CFN90306
Molecular Formula:	C₃₀H₄₄O₂
Molecular Weight:	436.68 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	White cryst.
Source:	The fruit body of Ganoderma lucidum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $413 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

The oxygenated sterols( 26-oxygenosterols ganoderol A, ganoderol B, ganoderal A, and ganoderic acid Y) from G. lucidum can inhibit cholesterol biosynthesis via conversion of acetate or mevalonate as a precursor of cholesterol.

In vitro:

Appl Environ Microbiol. 2005 Jul;71(7):3653-8.

Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors.[Pubmed: 16000773]

Ganoderma lucidum is a medicinal fungus belonging to the Polyporaceae family which has long been known in Japan as Reishi and has been used extensively in traditional Chinese medicine.
METHODS AND RESULTS:
We report the isolation and identification of the 26-oxygenosterols ganoderol A, ganoderol B, Ganoderal A, and ganoderic acid Y and their biological effects on cholesterol synthesis in a human hepatic cell line in vitro. We also investigated the site of inhibition in the cholesterol synthesis pathway. We found that these oxygenated sterols from G. lucidum inhibited cholesterol biosynthesis via conversion of acetate or mevalonate as a precursor of cholesterol. By incorporation of 24,25-dihydro-[24,25-3H2]lanosterol and [3-3H]lathosterol in the presence of ganoderol A, we determined that the point of inhibition of cholesterol synthesis is between lanosterol and lathosterol.
CONCLUSIONS:
These results demonstrate that the lanosterol 14alpha-demethylase, which converts 24,25-dihydrolanosterol to cholesterol, can be inhibited by the 26-oxygenosterols from G. lucidum. These 26-oxygenosterols could lead to novel therapeutic agents that lower blood cholesterol.

Ganoderal A Description

Source:	The fruit body of Ganoderma lucidum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-hyperlipidemic Compound Library Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.29 mL	11.45 mL	22.9001 mL	45.8001 mL	57.2502 mL
5 mM	0.458 mL	2.29 mL	4.58 mL	9.16 mL	11.45 mL
10 mM	0.229 mL	1.145 mL	2.29 mL	4.58 mL	5.725 mL
50 mM	0.0458 mL	0.229 mL	0.458 mL	0.916 mL	1.145 mL
100 mM	0.0229 mL	0.1145 mL	0.229 mL	0.458 mL	0.5725 mL

CFN99064	Ganoderol B	104700-96-1	440.7	C₃₀H₄₈O₂
CFN99065	Ganoderol A	104700-97-2	438.7	C₃₀H₄₆O₂
CFN95604	15,26-Dihydroxylanosta-7,9(11),24-trien-3-one	420781-85-7	454.7	C₃₀H₄₆O₃
CFN99244	Ganoderiol F	114567-47-4	454.7	C₃₀H₄₆O₃
CFN99085	Ganodermanondiol	107900-76-5	456.7	C₃₀H₄₈O₃
CFN80461	Ganoderiol A	106518-61-0	474.37	C₃₀H₅₀O₄
CFN99077	Ganodermanontriol	106518-63-2	472.7	C₃₀H₄₈O₄
CFN95617	New compound 25	N/A	470.7	C₃₀H₄₆O₄
CFN90304	Lucialdehyde A	420781-84-6	438.69	C₃₀H₄₆O₂
CFN90306	Ganoderal A	104700-98-3	436.68	C₃₀H₄₄O₂