Ganoderenic acid A | CAS:100665-40-5 | Manufacturer ChemFaces

Ganoderenic acid A

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Product Name	Ganoderenic acid A
Price:	$318 / 10mg
CAS No.:	100665-40-5
Catalog No.:	CFN92236
Molecular Formula:	C₃₀H₄₂O₇
Molecular Weight:	514.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The fruiting bodys of Ganoderma lucidum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $229.0 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Ganoderenic acid A has a potent hepatoprotective, and cytotoxic effects, it shows inhibitory activity on human aldose reductase in vitro.

In vitro:

Planta Med. 2010 Oct;76(15):1691-3.

Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum.[Pubmed: 20379959]

CHCl(3) extract of the fruiting body of Ganoderma lucidum was found to show inhibitory activity on human aldose reductase in vitro.
METHODS AND RESULTS:
From the acidic fraction, potent human aldose reductase inhibitors, ganoderic acid C2 (1) and Ganoderenic acid A (2), were isolated together with three related compounds.
CONCLUSIONS:
It was found that the free carboxyl group of ganoderic acid C2 and Ganoderenic acid A is essential in eliciting the inhibitory activity considering the much lower activity of their methyl esters.

Ganoderenic acid A Description

Source:	The fruiting bodys of Ganoderma lucidum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Biol Pharm Bull. 1999 Feb;22(2):162-4.

Beta-glucuronidase-inhibitory activity and hepatoprotective effect of Ganoderma lucidum.[Pubmed: 10077435]

To prove the relationship between the fluctuation in serum beta-glucuronidase level and hepatotoxicity, an inhibitor of beta-glucuronidase from G. lucidum was isolated and its hepatoprotective activity was investigated.
METHODS AND RESULTS:
The ether fraction of G. lucidum, which had potent beta-glucuronidase-inhibitory activity, protected against CCl4-induced liver injury. From this ether fraction, Ganoderenic acid A, was isolated as the potent inhibitor of beta-glucuronidase. It had a potent hepatoprotective effect against CCl4-induced liver injury.
CONCLUSIONS:
These results suggest that the beta-glucuronidase seems to be closely related to liver injury, which could be prevented by beta-glucuronidase inhibitors.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Hepatoprotective Compound Library Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9429 mL	9.7144 mL	19.4288 mL	38.8576 mL	48.572 mL
5 mM	0.3886 mL	1.9429 mL	3.8858 mL	7.7715 mL	9.7144 mL
10 mM	0.1943 mL	0.9714 mL	1.9429 mL	3.8858 mL	4.8572 mL
50 mM	0.0389 mL	0.1943 mL	0.3886 mL	0.7772 mL	0.9714 mL
100 mM	0.0194 mL	0.0971 mL	0.1943 mL	0.3886 mL	0.4857 mL

CFN91763	(5alpha)-11-dioxo-7,15-dihydroxy-4,4,14-trimethyl-3-Chol-8-en-24-oic acid	942936-54-1	460.61	C₂₇H₄₀O₆
CFN90574	Lucidenic acid A	95311-94-7	458.59	C₂₇H₃₈O₆
CFN95583	Methyl lucidenate A	105742-79-8	472.6	C₂₈H₄₀O₆
CFN93125	Lucidenic acid E	98665-17-9	516.63	C₂₉H₄₀O₈
CFN95569	Methyl lucidenate E2	98665-12-4	530.7	C₃₀H₄₂O₈
CFN95020	Lucidenic acid D2	98665-16-8	514.6	C₂₉H₃₈O₈
CFN92995	Lucidenic acid C	95311-96-9	476.60	C₂₇H₄₀O₇
CFN95541	Methyl lucidenate C	N/A	490.6	C₂₈H₄₂O₇
CFN92994	Lucidenic acid SP1 (Lucidenic acid LM1)	364622-33-3	460.60	C₂₇H₄₀O₆
CFN90829	20(21)-Dehydrolucidenic acid A	852936-69-7	456.6	C₂₇H₃₆O₆