Gardenine | CAS:139682-36-3 | Manufacturer ChemFaces

Gardenine

ChemFaces products have been cited in many studies from excellent and top scientific journals

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Description:

Gardenin has regulatory effect on the gene expression in rats with focal cerebral ischemia.

In vivo:

Planta Med. 1991 Dec;57(6):536-42.

Formation of nitrogen-containing metabolites from geniposide and gardenoside by human intestinal bacteria.[Pubmed: 1818345]

METHODS AND RESULTS:
During the course of our studies on the metabolism of iridoid glycosides by human intestinal bacteria, we found that geniposide (1) and gardenoside (4) were transformed to new nitrogen-containing compounds, genipinine (3) and Gardenine (6), respectively, along with the known aglycones. Although the amounts of new metabolites were somewhat lower than those of the aglycones, they were quantitatively analyzed by means of liquid chromatography/mass spectrometry (LC/MS).
CONCLUSIONS:
Of 25 strains of human intestinal bacteria, Peptostreptococcus anaerobius, Klebsiella pneumoniae, Fusobacterium nucleatum, and Bacteroides fragilis ssp. thetaotus produced appreciable amounts of 3, while a bacterial mixture of human feces produced 10 times or more higher amounts of 3, as compared to the individual strains.

Gardenine Description

Source:	The herbs of Nauclea officinalis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005 Jan;25(1):42-4.

Effect of gardenin on gene expression profile in brain of rats with focal cerebral ischemia[Pubmed: 15719750]

Total RNAs were isolated from rats with FCI and those treated with gardenin.
METHODS AND RESULTS:
The mRNAs were reversely transcribed to cDNA with incorporation of fluorescent Cy5- or Cy3-dUTP to prepare hybridization probes. The PCR products of 4096 genes were spotted on the chip after a serial treatment. The mixed probes were hybridized to the cDNA microarray. Axon Genepix 4000B and GenePixPro 3.0 software were used to scan and analyze the fluorescent signals. In the group treated with gardenin, there were 70 genes had expression profiles different to that in the model group in the focal cerebral ischemic brain tissue, in which 68 were up-regulated and 2 down-regulated.
CONCLUSIONS:
Gardenin has regulatory effect on the gene expression in rats with focal cerebral ischemia, which elucidates part of the pharmacologic mechanism of Qingkailing in molecular level.

Product Name	Gardenine
Price:
CAS No.:	139682-36-3
Catalog No.:	CFN99447
Molecular Formula:	C₁₁H₁₃NO₄
Molecular Weight:	223.2 g/mol
Purity:	>=98%
Type of Compound:	Iridoids
Physical Desc.:	Oil
Source:	The herbs of Nauclea officinalis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-cerebral ischemia Compound Library Iridoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.4803 mL	22.4014 mL	44.8029 mL	89.6057 mL	112.0072 mL
5 mM	0.8961 mL	4.4803 mL	8.9606 mL	17.9211 mL	22.4014 mL
10 mM	0.448 mL	2.2401 mL	4.4803 mL	8.9606 mL	11.2007 mL
50 mM	0.0896 mL	0.448 mL	0.8961 mL	1.7921 mL	2.2401 mL
100 mM	0.0448 mL	0.224 mL	0.448 mL	0.8961 mL	1.1201 mL

CFN96355	Splendoside	81969-41-7	406.4	C₁₇H₂₆O₁₁
CFN90753	Dipsanoside A	889678-62-0	1475.4	C₆₆H₉₀O₃₇
CFN90754	Dipsanoside B	889678-64-2	1475.4	C₆₆H₉₀O₃₇
CFN89296	7-Deoxy-10-hydroxyloganetin	76267-48-6	228.24	C₁₁H₁₆O₅
CFN91452	Deoxyloganin	26660-57-1	374.4	C₁₇H₂₆O₉
CFN99858	Loganin	18524-94-2	390.4	C₁₇H₂₆O₁₀
CFN95478	8-Epiloganin	79172-04-6	390.4	C₁₇H₂₆O₁₀
CFN95452	10-Carboxyloganin	182172-02-7	420.4	C₁₇H₂₄O₁₂
CFN98160	Cornin	548-37-8	388.37	C₁₇H₂₄O₁₀
CFN96588	Hastatoside	50816-24-5	404.37	C₁₇H₂₄O₁₁