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Ginkgolic acid C15:0
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Ginkgolic acid C15:0
Price:
CAS No.: 16611-84-0
Catalog No.: CFN90339
Molecular Formula: C22H36O3
Molecular Weight: 348.52 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The leaves of Ginkgo biloba L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Description: Reference standards.
Ginkgolic acid C15:0 Description
Source: The leaves of Ginkgo biloba L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8693 mL 14.3464 mL 28.6928 mL 57.3855 mL 71.7319 mL
5 mM 0.5739 mL 2.8693 mL 5.7386 mL 11.4771 mL 14.3464 mL
10 mM 0.2869 mL 1.4346 mL 2.8693 mL 5.7386 mL 7.1732 mL
50 mM 0.0574 mL 0.2869 mL 0.5739 mL 1.1477 mL 1.4346 mL
100 mM 0.0287 mL 0.1435 mL 0.2869 mL 0.5739 mL 0.7173 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Journal of Luminescence Volume 132, Issue 5, May 2012, Pages 1207–1214
Spectroscopic studies on the interaction of bovine serum albumin with ginkgolic acid: Binding characteristics and structural analysis[Reference: WebLink]
The interaction between Ginkgolic acid C15:0 and bovine serum albumin (BSA) is investigated by several spectroscopic methodologies.
METHODS AND RESULTS:
At first, the binding characteristics of Ginkgolic acid C15:0 and BSA are determined by fluorescence emission spectra. It is showed that Ginkgolic acid C15:0 quenches the fluorescence of BSA and the static quenching constant KLB is 11.7891×104 L mol−1 s−1 at 297 K. Ginkgolic acid C15:0 and BSA form a 1:1 complex with a binding constant of 9.12×105 L mol−1. Ginkgolic acid C15:0 binds to the Sudlow's drug binding site II in BSA, and the binding distance between them is calculated as 1.63 nm based on the Förster theory. The thermodynamic parameters indicate that the interaction between BSA and Ginkgolic acid C15:0 is driven mainly by hydrophobic forces. On the other hand, structural analysis indicates that Ginkgolic acid C15:0 binding results in an increased hydrophobicity around the tryptophan residues of BSA as revealed by the synchronous fluorescence spectra, and a decrease in α-helix as revealed by the far-UV CD spectra. In addition, ANS, UV–vis and RLS experiments confirmed that Ginkgolic acid C15:0 binding causes a certain structural changes in BSA.
CONCLUSIONS:
These findings provide the binding information between BSA and Ginkgolic acid C15:0), and may be helpful for pharmacokinetics and the design of dosage forms of Ginkgolic acid C15:0.
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