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Glochidone
Glochidone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Glochidone
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CAS No.: 6610-55-5
Catalog No.: CFN97127
Molecular Formula: C30H46O
Molecular Weight: 422.7 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The herbs of Glochidion puberum L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Glochidone shows pronounced antinociceptive properties in mice.
In vivo:
Revista Brasileira De Farmacognosia, 2012,22 (3) :682-713.
Review of the genus Ipomoea: traditional uses, chemistry and biological activities[Reference: WebLink]

METHODS AND RESULTS:
Study in mice indicated that both methanolic extract and two fractions (ethyl acetate and aqueous) exhibited antinociceptive activity against two classical models of pain, neurogenic and inflammatory. This study justifies at least in part, the traditional use of this plant to treat dolorous process (Souza et al., 2000).
CONCLUSIONS:
Some constituents isolated from I. pes-caprae, such as, quercetin 3-O-β-D-glucofuranoside (55), β-amyrin acetate (104) α-amyrin acetate (105), betulinic acid (107) and Glochidone (108) showed pronounced antinociceptive properties in mice.
Glochidone Description
Source: The herbs of Glochidion puberum L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3657 mL 11.8287 mL 23.6574 mL 47.3149 mL 59.1436 mL
5 mM 0.4731 mL 2.3657 mL 4.7315 mL 9.463 mL 11.8287 mL
10 mM 0.2366 mL 1.1829 mL 2.3657 mL 4.7315 mL 5.9144 mL
50 mM 0.0473 mL 0.2366 mL 0.4731 mL 0.9463 mL 1.1829 mL
100 mM 0.0237 mL 0.1183 mL 0.2366 mL 0.4731 mL 0.5914 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Australian Journal of Chemistry.1974;27(12):2711 - 2714.
Terpenoid constituents of Indian Glochidion species: Glochidion accuminatum and Glochidion thomsoni. Partial synthesis of glochidone.[Reference: WebLink]

METHODS AND RESULTS:
Glochidone (1), glochidonol(2) and β-sitosterol were isolated from Glochidion accuminatum while G. thomsoni furnished Glochidone (1), lup- 20(29)-ene-1β,3β-diol (3) and β-sitosterol. A partial synthesis of Glochidone has been achieved in 25% yield by the 2,3-dichloro-5,6- dicyanobenzoquinone dehydrogenation of lupenone.
CFN97717Lup-20(29)-ene-2alpha,3beta-diol61448-03-1442.73C30H50O2
CFN97128Glochidiol6610-56-6442.7 C30H50O2
CFN983603-Epiglochidiol29028-10-2442.7 C30H50O2
CFN971223-Epiglochidiol diacetate6587-37-7526.8 C34H54O4
CFN8928811beta-Hydroxylupeol49776-92-3442.72C30H50O2
CFN91560Obtusalin125164-64-9442.7C30H50O2
CFN89066Adiantulupanone51511-05-8412.70C29H48O
CFN9638829-Nor-20-oxolupeol19891-85-1428.7C29H48O2
CFN9638330-Oxolupeol64181-07-3440.7C30H48O2
CFN98248Glochidonol23963-54-4440.7 C30H48O2
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