Alloimperatorin | CAS:642-05-7 | Manufacturer ChemFaces

Alloimperatorin

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Description:

Alloimperatorin exhibits in vitro antitumor activity in HL-60 acute myeloid leukemia cancer cells via inducing apoptosis, cell cycle disruption and inhibition of cell migration. It photosensitizes efficiently the hemolysis of erythrocytes.

In vitro:

Bangladesh Journal of Pharmacology, 2016, 11(1):194.

Alloimperatorin and its epoxide derivative exhibit in vitro antitumor activity in HL-60 acute myeloid leukemia cancer cells via inducing apoptosis, cell cycle disruption and inhibition of cell migration[Reference: WebLink]

The aim of the present study was to synthesize epoxide derivative of Alloimperatorin and evaluating its antitumor and apoptotic effects in acute myeloid leukemia HL-60 cells.
METHODS AND RESULTS:
The cytotoxic effects were demonstrated by MTT assay. Fluorescence microscopy along with flow cytometry were performed to evaluate the effect of Alloimperatorin epoxide on apoptosis and cell cycle. In vitro wound healing assay was performed to study compounds effect on cancer cell migration.
METHODS AND RESULTS:
The results indicated that Alloimperatorin epoxide (IC50 = 32.1 μM) was much more effective in inhibiting HL-60 cancer cell growth as compared to Alloimperatorin (IC50 = 128 μM). Further, Alloimperatorin epoxide induced apoptosis related morphological alterations in HL-60 cells including blebbing of plasma membrane, DNA fragmentation and formation of apoptotic bodies. Alloimperatorin epoxide also led to G2/M phase cell cycle arrest and suppressed HL-60 cancer cell migration indicating that this compound may be a promising candidate for the treatment of cancer metastasis.

Photochemistry & Photobiology, 2014, 90(1):162-170.

Photohemolysis Sensitized by the Furocoumarin Derivative Alloimperatorin and its Hydroperoxide Photooxidation Product.[Pubmed: 24117477]

METHODS AND RESULTS:
The dark and photosensitized effects of Alloimperatorin methyl ether 1 (hereafter simply Alloimperatorin) and its photooxygenation product Alloimperatorin hydroperoxide 2 were investigated on human erythrocytes. The results reveal that the furocoumarin 1 photosensitizes efficiently the hemolysis of erythrocytes. The rate of photohemolysis increases on raising the temperature of the postirradiated incubation from 4°C to 37°C. Thermal activation of the photohemolysis and inhibition by 2,6-di-tert-butyl-p-cresol (BHT) suggest that the furocoumarin 1 photosensitizes lipid peroxidation, increasing permeability in the erythrocyte membrane. The hydroperoxide 2 induces dark and photosensitized hemolysis more efficiently than the furocoumarin 1. The rate of hemolysis induced by 2 increases with the incubation temperature and decreases in the presence of tert-butanol and BHT. The hydroperoxide 2 photosensitizes the formation of lipid peroxidation products as shown by the reaction with thiobarbituric acid. This process is diminished by BHT.
CONCLUSIONS:
Our data imply that the photohemolysis sensitized by the furocoumarin 1 is caused by the in situ-formed photooxygenation product 2. Such hydroperoxides are potent hemolytic agents in the dark and especially on photosensitization.

Alloimperatorin Description

Source:	The herbs of Angelica dahurica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Alloimperatorin
Price:	$298 / 10mg
CAS No.:	642-05-7
Catalog No.:	CFN93037
Molecular Formula:	C₁₆H₁₄O₄
Molecular Weight:	270.28 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Source:	The herbs of Angelica dahurica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Coumarins Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.6999 mL	18.4993 mL	36.9987 mL	73.9973 mL	92.4967 mL
5 mM	0.74 mL	3.6999 mL	7.3997 mL	14.7995 mL	18.4993 mL
10 mM	0.37 mL	1.8499 mL	3.6999 mL	7.3997 mL	9.2497 mL
50 mM	0.074 mL	0.37 mL	0.74 mL	1.4799 mL	1.8499 mL
100 mM	0.037 mL	0.185 mL	0.37 mL	0.74 mL	0.925 mL

CFN95012	Alloisoimperatorin	35214-83-6	270.3	C₁₆H₁₄O₄
CFN93037	Alloimperatorin	642-05-7	270.28	C₁₆H₁₄O₄
CFN90495	Phellopterin	2543-94-4	300.3	C₁₇H₁₆O₅
CFN98167	Byakangelicol	26091-79-2	316.31	C₁₇H₁₆O₆
CFN98152	Byakangelicin	482-25-7	334.32	C₁₇H₁₈O₇
CFN98462	Neobyakangelicol	35214-82-5	316.3	C₁₇H₁₆O₆