Glycoborinine | CAS:233279-39-5 | Manufacturer ChemFaces

Glycoborinine

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Description:

Glycoborinine is a potential molecule against cancer cells, it can induce HepG2 apoptosis through the mitochondrial-dependent pathway. Glycoborinine has photo-activated antimicrobial activity, it shows moderate inhibition on Nde I, Xba I, Nco I and Bcl I.

Targets:

In vitro:

Yao Xue Xue Bao. 2012 Dec;47(12):1646-52.

Photo-activated DNA binding and antimicrobial activities of alkaloids from Glycosmis pentaphylla.[Pubmed: 23460971]

In our screening for photosensitizers from natural resources, four
METHODS AND RESULTS:
alkaloids were isolated from Glycosmis pentaphylla by various chromatography techniques.Their structures were identified as Glycoborinine (1), glybomine B (2), carbalexin A (3) and N-p-coumaroyltyramine (4) by spectral analysis. Their photoactivated antimicrobial activities were evaluated by thin-layer chromatography (TLC) agar overlay assay against Staphylococcus aureus and Bacillus subtilis. It was found that compounds 1 and 4 showed photo-activated antimicrobial activities. Meantime, photo-activated DNA binding activities of these compounds were also assessed by using a specially prepared 1.8 kb DNA fragment and restriction enzymes.
CONCLUSIONS:
Under UVA irradiation, compound 1 showed moderate inhibition on Nde I, Xba I, Nco I and Bcl I which have either 5'-TpA or 5'-ApT and trace or no inhibition on other restriction enzymes. It showed a similar inhibition pattern with the reference 8-methoxypsoralen. However, compounds 2-4 showed no inhibition against any of the restriction enzymes.

Glycoborinine Description

Source:	The herbs of Glycosmis pentaphylla.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

J Asian Nat Prod Res. 2014 Oct;16(10):991-9

Glycoborinine induces apoptosis through mitochondrial pathway in HepG2 cells.[Pubmed: 24930917]

Glycoborinine (GB), a natural carbazole alkaloid isolated from Glycosmis pentaphylla, has been shown to be a potential molecule against cancer cells.
METHODS AND RESULTS:
In this study, the cell-signaling pathway of its anti-tumor activity was investigated. MTT assay result showed that GB inhibited HepG2 cell proliferation in a dose- and time-dependent manner and 50% inhibiting concentration (IC50) of GB-induced cell death was 39.7 μM for a period of 48 h. GB-induced HepG2 apoptosis was confirmed by Hochest 33258 staining and PI staining. The level of reactive oxygen species (ROS) was measured with H2DCF-DA staining and the change of mitochondrial membrane potential (△Ψ(m)) was analyzed with tetrechloro-tetraethylbenzimidazolcarbocyanine iodide (JC-1) probe. Results showed that GB at 12.5, 25, and 50 μM promoted ROS production. GB induced HepG2 apoptosis through a mitochondrial apoptotic pathway, which was demonstrated by GB-induced increase in the ratio of Bax/Bcl-2, cytochrome C release, the ratio of cleaved caspase-3/procaspase-3, and the ratio of cleaved poly ADP-ribose polymerase (cleaved PARP)/poly ADP-ribose polymerase (PARP).
CONCLUSIONS:
To summarize, this study demonstrated that GB could induce HepG2 apoptosis through the mitochondrial-dependent pathway, which might provide a promising approach to cure liver cancer with GB.

Product Name	Glycoborinine
Price:
CAS No.:	233279-39-5
Catalog No.:	CFN89173
Molecular Formula:	C₁₈H₁₇NO₂
Molecular Weight:	279.33 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Glycosmis pentaphylla.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Inhibitors Compound Library Antibacterial Compound Library Antifungal Compound Library Pro-apoptotic Compound Library Alkaloids Compound Library ROS Inhibitor Library PARP Inhibitor Library Caspase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.58 mL	17.9 mL	35.7999 mL	71.5999 mL	89.4999 mL
5 mM	0.716 mL	3.58 mL	7.16 mL	14.32 mL	17.9 mL
10 mM	0.358 mL	1.79 mL	3.58 mL	7.16 mL	8.95 mL
50 mM	0.0716 mL	0.358 mL	0.716 mL	1.432 mL	1.79 mL
100 mM	0.0358 mL	0.179 mL	0.358 mL	0.716 mL	0.895 mL

CFN92201	Murrayanol	144525-81-5	363.5	C₂₄H₂₉NO₂
CFN89173	Glycoborinine	233279-39-5	279.33	C₁₈H₁₇NO₂
CFN96594	Carbazole	86-74-8	167.21	C₁₂H₉N
CFN97777	3-Methyl-9H-carbazol-2-ol	24224-30-4	197.23	C₁₃H₁₁NO
CFN98862	Glycozolinine	5257-08-9	197.2	C₁₃H₁₁NO
CFN97821	Clausine D	142846-95-5	279.34	C₁₈H₁₇NO₂
CFN97840	Demethylmurrayanine	123497-84-7	211.22	C₁₃H₉NO₂
CFN91484	Murrayanine	723-97-7	225.2	C₁₄H₁₁NO₂
CFN91823	Clausine E	182261-83-2	241.2	C₁₄H₁₁NO₃
CFN91427	Clausine G	186002-62-0	271.3	C₁₅H₁₃NO₄