Gramodendrine | CAS:83905-67-3 | Manufacturer ChemFaces

Gramodendrine

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Gramodendrine and ammodendrine are moderately potent (300 mg/kg, ip) in reducing spontaneous motor activity (30% of control) and in causing central nervous system depression (50% of control). spect.

In vivo:

Journal of Agricultural & Food Chemistry, 1985,33 (5) :909-912.

Identification of toxic alkaloids from the calcaratus subspecies of Lupinus arbustus.[Reference: WebLink]

A recent chemical study of the previously uninvestigated Lupinus arbustus subspecies calcaratus resulted in the isolation and characterization of the novel bipiperidyl-indole alkaloid Gramodendrine.
METHODS AND RESULTS:
The present study describes the identification of three additional structurally diverse alkaloids from the title plant. These include the quinolizidine base lusitanine, the piperidine derivative ammodendrine, and the indole alkylamine gramine. The total alkaloid fraction as well as the first three of the above individual alkaloids were tested for gross locomotor activity and for rotorod performance in mice.
CONCLUSIONS:
Pharmacologic data indicated that Gramodendrine and ammodendrine were moderately potent (300 mg/kg, ip) in reducing spontaneous motor activity (30% of control) and in causing central nervous system depression (50% of control).

Gramodendrine Description

Source:	The herbs of Lupinus arbustus subsp. calcaratus.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Gramodendrine
Price:
CAS No.:	83905-67-3
Catalog No.:	CFN00443
Molecular Formula:	C₂₁H₂₇N₃O
Molecular Weight:	337.40 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Lupinus arbustus subsp. calcaratus.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Central nervous system depressant action Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9638 mL	14.8192 mL	29.6384 mL	59.2768 mL	74.096 mL
5 mM	0.5928 mL	2.9638 mL	5.9277 mL	11.8554 mL	14.8192 mL
10 mM	0.2964 mL	1.4819 mL	2.9638 mL	5.9277 mL	7.4096 mL
50 mM	0.0593 mL	0.2964 mL	0.5928 mL	1.1855 mL	1.4819 mL
100 mM	0.0296 mL	0.1482 mL	0.2964 mL	0.5928 mL	0.741 mL

CFN00443	Gramodendrine	83905-67-3	337.40	C₂₁H₂₇N₃O
CFN90001	5-[(2R)-2-Aminopropyl]-2,3-dihydro-1-[3-(phenylmethoxy)propyl]-1H-indole-7-carbonitrile	459868-73-6	349.47	C₂₂H₂₇N₃O
CFN90023	5-[(2R)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate	239463-85-5	513.55	C₂₆H₃₁N₃O₈
CFN96171	3-Hydroxy-3-acetonyloxindole	33417-17-3	205.2	C₁₁H₁₁NO₃
CFN93321	Tamoxifen	10540-29-1	371.51	C₂₆H₂₉NO