Grayanotoxin I | CAS:4720-09-6 | Manufacturer ChemFaces

Grayanotoxin I

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Description:

Grayanotoxin I has an inhibitory effect on the initiation of action potentials of fibers of both muscles. This toxin causes a gradual decrease of the resting potential and an elevation of the critical firing level.

Targets:

Sodium Channel

In vitro:

The Japanese Journal of Physiology, 1970, 20(4):381-393.

Effect of grayanotoxin I on the electrical properties of rat skeletal muscle.[Reference: WebLink]

METHODS AND RESULTS:
1. Effect of Grayanotoxin I on the soleus and extensor digitorum longus muscles of rats was studied by the electrophysiological methods.2. Grayanotoxin I has an inhibitory effect on the initiation of action potentials of fibers of both muscles. This toxin causes a gradual decrease of the resting potential and an elevation of the critical firing level.
CONCLUSIONS:
3. As decrease in resting potential induced by this toxin was always associated with reduction of the effective membrane resistance and these phenomena were not observed upon withdrawal of Na from the medium, depolarization of the membrane in the toxic solution is considered to be due to increased permeability of the membrane to Na ions.

Grayanotoxin I Description

Source:	The herbs of Pieris japonica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Grayanotoxin I
Price:
CAS No.:	4720-09-6
Catalog No.:	CFN70369
Molecular Formula:	C₂₂H₃₆O₇
Molecular Weight:	412.5 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The herbs of Pieris japonica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Diterpenoids Compound Library Sodium Channel Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4242 mL	12.1212 mL	24.2424 mL	48.4848 mL	60.6061 mL
5 mM	0.4848 mL	2.4242 mL	4.8485 mL	9.697 mL	12.1212 mL
10 mM	0.2424 mL	1.2121 mL	2.4242 mL	4.8485 mL	6.0606 mL
50 mM	0.0485 mL	0.2424 mL	0.4848 mL	0.9697 mL	1.2121 mL
100 mM	0.0242 mL	0.1212 mL	0.2424 mL	0.4848 mL	0.6061 mL

CFN60447	PHA-680632	398493-79-3	501.62	C₂₈H₃₅N₇O₂
CFN91870	Delphinidin-3-O-sambubioside-5-O-glucoside chloride	36415-91-5	795.1	C₃₂H₃₉ClO₂₁
CFN98347	Tomentin	28449-62-9	222.2	C₁₁H₁₀O₅
CFN70349	Vescalagin	36001-47-5	934.6	C₄₁H₂₆O₂₆