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Griffithazanone A
Griffithazanone A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Griffithazanone A
Price:
CAS No.: 240122-30-9
Catalog No.: CFN97943
Molecular Formula: C14H11NO4
Molecular Weight: 257.2 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Yellow powder
Source: The herbs of Goniothalamus yunnanensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Reference standards.
In vitro:
Fitoterapia. 2010 Oct;81(7):894-6.
A new cytotoxic 1-azaanthraquinone from the stems of Goniothalamus laoticus.[Pubmed: 20554005]

METHODS AND RESULTS:
A new 1-azaanthraquinone, named laoticuzanone A (1), and a synthetically known 3-methyl-1H-1-azaanthracene-2,9,10-trione (2), together with four known compounds, Griffithazanone A (3), methyl sinapate (4), methyl p-coumarate (5), and p-hydroxyphenylethyl p-coumarate (6) were isolated from the stems of Goniothalamus laoticus. Their structures were established on the basis of spectroscopic data as well as comparisons with the previous literature data.
CONCLUSIONS:
Compound 1 showed the highest cytotoxicity against KB and HeLa cells with IC(50) values of 0.68 and 0.50 μg/ml, respectively.
Griffithazanone A Description
Source: The herbs of Goniothalamus yunnanensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.888 mL 19.4401 mL 38.8802 mL 77.7605 mL 97.2006 mL
5 mM 0.7776 mL 3.888 mL 7.776 mL 15.5521 mL 19.4401 mL
10 mM 0.3888 mL 1.944 mL 3.888 mL 7.776 mL 9.7201 mL
50 mM 0.0778 mL 0.3888 mL 0.7776 mL 1.5552 mL 1.944 mL
100 mM 0.0389 mL 0.1944 mL 0.3888 mL 0.7776 mL 0.972 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chem Pharm Bull (Tokyo). 2006 Jul;54(7):1040-3.
New constituents from stems of Goniothalamus amuyon.[Pubmed: 16819228]

METHODS AND RESULTS:
Two new compounds, goniothalesacetate (1) and goniothalesdiol A (2) together with goniodiol-7-monoacetate, goniodiol-8-monoacetate, leiocarpin C, liriodenine, Griffithazanone A, 4-methyl-2,9,10-(2H)-1-azaanthracencetrione, velutinam and aristolactam BII were isolated and characterized from the stems of Goniothalamus amuyon. Structures of new compounds were determined by spectral analysis.
CFN95782Epicatechin 3-O-(4-O-methylgallate)108907-44-4456.4C23H20O10
CFN92335N-Methylcorydaldine6514-05-2221.3C12H15NO3
CFN92336Thalifoline21796-15-6207.2C11H13NO3
CFN95441Oleracein E1021950-79-7219.2C12H13NO3
CFN956211-Methyl-6,8-dimethoxyquinoline-2 1H-one1210820-67-9219.2C12H13NO3
CFN96376Ravenine20105-22-0243.3C15H17NO2
CFN979554-Methoxy-1-methylquinolin-2-one32262-18-3189.2C11H11NO2
CFN92352Atanine7282-19-1243.3C15H17NO2
CFN95772Flindersine523-64-8227.3C14H13NO2
CFN92735N-Methylflindersine50333-13-6241.3C15H15NO2
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