Gymnemagenin | CAS:22467-07-8 | Manufacturer ChemFaces

Gymnemagenin

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Description:

Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity, it can be considered further for development into a potent anti-diabetic drug.

Targets:

Liver X Receptor

In vitro:

J Theor Biol. 2016 Feb 21;391:95-101.

In-silico analysis of gymnemagenin from Gymnema sylvestre (Retz.) R.Br. with targets related to diabetes.[Pubmed: 26711684 ]

Diabetes is a metabolic disorder characterized by higher than normal glucose in the blood. Most oral hypoglycemic drugs available in market produce adverse side effects which have resulted in continued search for new therapeutic agents with little or no side effects. Herbal drugs are considered relatively safer alternatives and Gymnema sylvestre is one of the most well established natural remedy for diabetes and is traded worldwide under several brands.
METHODS AND RESULTS:
In the present study an attempt has been made to use in silico techniques to understand and predict the drug likeliness of Gymnemagenin, one of the key constituents of G. sylvestre against 15 proteins having key role in carbohydrate metabolism. Gymnemagenin was found to dock well with crystallographic structures of 7 of the 15 selected targets and was found even better than the two known clinically used antidiabetic compounds, repaglinide and sitagliptin taken in the study for comparison.
CONCLUSIONS:
Gymnemagenin therefore can be considered further for development into a potent anti-diabetic drug.

In vivo:

J Agric Food Chem. 2012 Mar 14;60(10):2517-24.

Hypoglycemic activity of Gymnema sylvestre extracts on oxidative stress and antioxidant status in diabetic rats.[Pubmed: 22360666 ]

Diabetes mellitus, which is associated with oxidative damage, has a significant impact on health, quality of life, and life expectancy. An ethanol extract of Gymnema sylvestre leaf was examined in vitro and in vivo to investigate the role of antioxidants in diabetic rats.
METHODS AND RESULTS:
The extract exhibited strong antioxidant activity in the assays, including TBA (56%), SOD-like (92%), and ABTS (54%). Blood glucose levels in the diabetic rats fed G. sylvestre extract decreased to normal levels. The presence of the antihyperglycemic compounds Gymnemagenin and gymnemic acids in G. sylvestre extract was detected by LC/MS analysis. Lipid peroxidation levels were decreased by 31.7% in serum, 9.9% in liver, and 9.1% in kidney in the diabetic rats fed the extract. Feeding G. sylvestre extract to the diabetic rats decreased the activity of glutathione peroxidase in cytosolic liver and glutamate pyruvate transaminase in serum to normal levels.

Gymnemagenin Description

Source:	The leaves of Gymnema sylvestre.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Steroids. 2015 Apr;96:121-31.

Molecular decodification of gymnemic acids from Gymnema sylvestre. Discovery of a new class of liver X receptor antagonists.[Pubmed: 25668616]

The individual chemical components of commercial extract of Gymnema sylvestre, a medicinal plant used in the traditional systems of the Indian medicine for its antidiabetic and hypolipidemic properties, were isolated and evaluated for their capability to act as modulators of nuclear and membrane receptors involved in glucose and lipid homeostasis.
METHODS AND RESULTS:
The study disclosed for the first time that individual gymnemic acids are potent and selective antagonists for the β isoform of LXR. Indeed the above activity was shared by the most abundant aglycone Gymnemagenin (10) whereas gymnestrogenin (11) was endowed with a dual LXRα/β antagonistic profile. Deep pharmacological investigation demonstrated that gymnestrogenin, reducing the expression of SREBP1c and ABCA1 in vitro, is able to decrease lipid accumulation in HepG2 cells.
CONCLUSIONS:
The results of this study substantiate the use of G. sylvestre extract in LXR mediated dislypidemic diseases.

Product Name	Gymnemagenin
Price:	$268 / 10mg
CAS No.:	22467-07-8
Catalog No.:	CFN90961
Molecular Formula:	C₃₀H₅₀O₆
Molecular Weight:	506.71 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The leaves of Gymnema sylvestre.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antihyperglycemic Compound Library Anti-diabetic Compound Library Antagonists Compound Library Triterpenoids Compound Library Liver X Receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9735 mL	9.8676 mL	19.7352 mL	39.4703 mL	49.3379 mL
5 mM	0.3947 mL	1.9735 mL	3.947 mL	7.8941 mL	9.8676 mL
10 mM	0.1974 mL	0.9868 mL	1.9735 mL	3.947 mL	4.9338 mL
50 mM	0.0395 mL	0.1974 mL	0.3947 mL	0.7894 mL	0.9868 mL
100 mM	0.0197 mL	0.0987 mL	0.1974 mL	0.3947 mL	0.4934 mL

CFN99870	Melilotigenin C	188970-21-0	456.7	C₃₀H₄₈O₃
CFN97479	Melilotigenin B	91269-84-0	454.7	C₃₀H₄₆O₃
CFN98704	alpha-Boswellic acid	471-66-9	456.7	C₃₀H₄₈O₃
CFN90529	3-O-Acetyl-alpha-boswellic acid	89913-60-0	498.74	C₃₂H₅₀O₄
CFN95916	3-O-Acetyl-11-methoxy-alpha-boswellic acid	1619260-05-7	528.8	C₃₃H₅₂O₅
CFN96343	Beta-Peltoboykinolic acid	24778-48-1	456.7	C₃₀H₄₈O₃
CFN98004	Erythrodiol 3-palmitate	19833-13-7	681.1	C₄₆H₈₀O₃
CFN90948	23-Hydroxylongispinogenin	42483-24-9	474.72	C₃₀H₅₀O₄
CFN90966	Gymnestrogenin	19942-02-0	490.72	C₃₀H₅₀O₅
CFN90961	Gymnemagenin	22467-07-8	506.71	C₃₀H₅₀O₆