Science | Nature | Cell | View More
Natural Products
Hautriwaic acid
Hautriwaic acid
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Hautriwaic acid
Price:
CAS No.: 18411-75-1
Catalog No.: CFN97799
Molecular Formula: C20H28O4
Molecular Weight: 332.44 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The herbs of Dodonaea viscosa
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Auburn University (USA)
  • Florida A&M University (USA)
  • Medizinische Universit?t Wien (Austria)
  • Macau University of Science and... (China)
  • Institute of Chinese Materia Me... (China)
  • Molecular Biology Institute of ... (Spain)
  • University of Limpopo (South Africa)
  • Complutense University of Madrid (Spain)
  • Universidad de La Salle (Mexico)
  • Kazusa DNA Research Institute (Japan)
  • More...
Package
Featured Products
Cyanidin-3-O-(6''-malonylglucoside...

Catalog No: CFN91864
CAS No: 171828-62-9
Price: $613/5mg
(+)-Camphor

Catalog No: CFN94889
CAS No: 464-49-3
Price: $30/20mg
Deoxyandrographolide

Catalog No: CFN90518
CAS No: 79233-15-1
Price: $288/20mg
Physcion

Catalog No: CFN98848
CAS No: 521-61-9
Price: $40/20mg
Semilicoisoflavone B

Catalog No: CFN90818
CAS No: 129280-33-7
Price: $318/5mg
9-Hydroxycalabaxanthone

Catalog No: CFN98467
CAS No: 35349-68-9
Price: $218/5mg
Daucosterol

Catalog No: CFN98713
CAS No: 474-58-8
Price: $80/20mg
Stylopine

Catalog No: CFN92812
CAS No: 84-39-9
Price: $ / mg
Limonin

Catalog No: CFN99280
CAS No: 1180-71-8
Price: $40/20mg
Glucobrassicin

Catalog No: CFN00484
CAS No: 143231-38-3
Price: $ / mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Hautriwaic acid shows anti-inflammatory activity in 12-O-tetradecanoylphorbol 13-acetate (TPA) mice ear edema models, it diminishes the joint edema induced by this mixture of polysaccharides (carrageenan), possibly by acting as immunomodulator of the inflammatory response. Hautriwaic acid present in the methanolic extract and its ethyl acetate, and aqueous fractions may be responsible for this hepatoprotective activity of Dodonaea viscosa which was confirmed by in vivo experiments.
Targets: Immunology & Inflammation related
In vivo:
Planta Med. 2015 Sep;81(14):1240-7.
Effect of Hautriwaic Acid Isolated from Dodonaea viscosa in a Model of Kaolin/Carrageenan-Induced Monoarthritis.[Pubmed: 26166136]
In the present work, the antiarthritic activity of Hautriwaic acid is reported.
METHODS AND RESULTS:
This ent-clerodane diterpene isolated from Dodonaea viscosa was evaluated in mice using a kaolin/carrageenan-induced monoarthritis model. The inflammation observed in the joint (knee) on days 1-8 ranged from 50-70 %. After 10 days of treatment with different doses of Hautriwaic acid (5, 10, 20 mg/kg), a decrease in knee inflammation was detected. This recovery was observed with both reference drugs, methotrexate (1 mg/kg) and diclofenac (0.75 mg/kg). In these groups of mice, the concentration of proinflammatory cytokines interleukin-1 beta, interleukin-6, and tumor necrosis factor alpha in the joint was significantly lower than that of the negative control group (animals with damage without any treatment). The negative control group presented a decrease in the concentration of interleukin-10, while the groups that received Hautriwaic acid at different dose exhibited an increase in this interleukin.
CONCLUSIONS:
This anti-inflammatory cytokine was not modified in the joint of mice with diclofenac, but in mice that received methotrexate, a significant decrease was observed. Hautriwaic acid isolated from D. viscosa diminished the joint edema induced by this mixture of polysaccharides (carrageenan), possibly by acting as immunomodulator of the inflammatory response.
Molecules. 2012 Apr 10;17(4):4292-9.
Anti-inflammatory activity of hautriwaic acid isolated from Dodonaea viscosa leaves.[Pubmed: 22491678]
The aim of this study was to identify an anti-inflammatory compound from D. viscosa leaves.
METHODS AND RESULTS:
The structure of this bioactive substance was elucidated by IR and NMR studies, which indicated that this natural product corresponds to Hautriwaic acid (HA). This diterpene exhibited good anti-inflammatory activity in 12-O-tetradecanoylphorbol 13-acetate (TPA) mice ear edema models by applications at doses of 0.25, 0.5 and 1.0 mg/ear (60.2, 70.2 and 87.1% inhibition, respectively); additionally Dodonaea viscosa dichloro-methane extract (DvDE) displays a 97.8% anti-inflammatory effect at 3 mg/kg. Multiple applications of DvDE at doses of 100 mg/kg on TPA mice ear edema inhibited the edema-associated inflammation by 71.8%, while HA at doses of 15 mg/kg, reduced edema to 64% and indomethacin 40%.
Hautriwaic acid Description
Source: The herbs of Dodonaea viscosa
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Deoxy euphorbia factor L1

Catalog No: CFN95340
CAS No: 247099-01-0
Price: $318/10mg
2,11,12-Trihydroxy-7,20-epoxy-8,11...

Catalog No: CFN95428
CAS No: 1608462-12-9
Price: $318/10mg
Jacquilenin

Catalog No: CFN95434
CAS No: 7726-34-3
Price: $318/5mg
Tuberosin

Catalog No: CFN95107
CAS No: 41347-45-9
Price: $218/5mg
(1S,2S)-threo-Honokitriol

Catalog No: CFN95076
CAS No: 1099687-80-5
Price: $413/5mg
Tessaric acid

Catalog No: CFN95182
CAS No: 58142-10-2
Price: $318/5mg
Moreollic acid

Catalog No: CFN95437
CAS No: 173792-68-2
Price: $318/5mg
11alpha-hydroxy-3,7-dioxo-5alpha-l...

Catalog No: CFN95592
CAS No: 1245703-70-1
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0081 mL 15.0403 mL 30.0806 mL 60.1612 mL 75.2015 mL
5 mM 0.6016 mL 3.0081 mL 6.0161 mL 12.0322 mL 15.0403 mL
10 mM 0.3008 mL 1.504 mL 3.0081 mL 6.0161 mL 7.5202 mL
50 mM 0.0602 mL 0.3008 mL 0.6016 mL 1.2032 mL 1.504 mL
100 mM 0.0301 mL 0.1504 mL 0.3008 mL 0.6016 mL 0.752 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Animal Research:
Phytomedicine. 2014 Jan 15;21(2):131-40.
Hautriwaic acid as one of the hepatoprotective constituent of Dodonaea viscosa.[Pubmed: 24075215]
It is widely known that hepatitis and its complications such as cirrhosis or hepatocellular carcinoma are one of the major health problems of the world especially since no specific treatment is available.
METHODS AND RESULTS:
In the present study we investigated the hepatoprotective potential of the methanolic extract of the whole plant of Dodonaea viscosa and its ethyl acetate, aqueous, butanol and n-hexane fractions against carbon tetrachloride (CCl₄) induced hepatoxicity in rats. Hepatoprotection was assessed in terms of reduction in serum enzymes (ALT, AST, and ALP) that occur after CCl₄ injury, and by histopathology and immunohistochemistry. The methanolic extract reduced the serum enzyme level (ALT, AST, and ALP) down to control levels despite CCl₄ treatment. It also reduced the CCl₄-induced damaged area to 0% as assessed by histopathology. The CD68+ macrophages were also reduced in number around the central vein area by the methanolic extract. These hepatoprotective effects were better than the positive control silymarin. Similar hepatoprotective activities were found with the ethyl acetate, and aqueous fractions of the methanolic extract. The butanol and n-hexane fractions showed elevated levels of ALT, AST and ALP as compared to the positive control silymarin. Histopathology showed ∼30% damage to the liver cells with the butanol and n-hexane fractions which still showed some protective activity compared to the CCl₄ treated control.
CONCLUSIONS:
HPLC fingerprinting suggested that Hautriwaic acid present in the methanolic extract and its ethyl acetate, and aqueous fractions may be responsible for this hepatoprotective activity of Dodonaea viscosa which was confirmed by in vivo experiments.
Cyanidin-3-O-(6''-malonylglucoside...

Catalog No: CFN91864
CAS No: 171828-62-9
Price: $613/5mg
(+)-Camphor

Catalog No: CFN94889
CAS No: 464-49-3
Price: $30/20mg
Deoxyandrographolide

Catalog No: CFN90518
CAS No: 79233-15-1
Price: $288/20mg
Physcion

Catalog No: CFN98848
CAS No: 521-61-9
Price: $40/20mg
Semilicoisoflavone B

Catalog No: CFN90818
CAS No: 129280-33-7
Price: $318/5mg
9-Hydroxycalabaxanthone

Catalog No: CFN98467
CAS No: 35349-68-9
Price: $218/5mg
Daucosterol

Catalog No: CFN98713
CAS No: 474-58-8
Price: $80/20mg
Stylopine

Catalog No: CFN92812
CAS No: 84-39-9
Price: $ / mg
Limonin

Catalog No: CFN99280
CAS No: 1180-71-8
Price: $40/20mg
Glucobrassicin

Catalog No: CFN00484
CAS No: 143231-38-3
Price: $ / mg
Tags: buy Hautriwaic acid | Hautriwaic acid supplier | purchase Hautriwaic acid | Hautriwaic acid cost | Hautriwaic acid manufacturer | order Hautriwaic acid | Hautriwaic acid distributor