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Hederacoside D
Hederacoside D
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Hederacoside D
Price: $118 / 20mg
CAS No.: 760961-03-3
Catalog No.: CFN90184
Molecular Formula: C53H86O22
Molecular Weight: 1074.56 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: White powder
Source: The herbs of Hedera nepalensis.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $68.5 / In-stock
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Hederacoside D is a narural product from Hedera nepalensis.
Hederacoside D Description
Source: The herbs of Hedera nepalensis.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 0.9306 mL 4.6531 mL 9.3061 mL 18.6123 mL 23.2653 mL
5 mM 0.1861 mL 0.9306 mL 1.8612 mL 3.7225 mL 4.6531 mL
10 mM 0.0931 mL 0.4653 mL 0.9306 mL 1.8612 mL 2.3265 mL
50 mM 0.0186 mL 0.0931 mL 0.1861 mL 0.3722 mL 0.4653 mL
100 mM 0.0093 mL 0.0465 mL 0.0931 mL 0.1861 mL 0.2327 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Sep Sci. 2016 Sep;39(17):3292-301.
Pharmacokinetic parameters of three active ingredients hederacoside C, hederacoside D, and ɑ-hederin in Hedera helix in rats.[Pubmed: 27377040 ]
In Hedera helix hederacoside C, Hederacoside D, and ɑ-hederin are three major bioactive saponins and play pivotal roles in the overall biological activity.
METHODS AND RESULTS:
In this study, a specific and sensitive ultra-high performance liquid chromatography with tandem mass spectrometry method has been developed and validated for the quantification of three major bioactive saponins in rat plasma. Chromatographic separation was performed on a reversed-phase Thermo Hypersil GOLD C18 column (2.1 mm × 50 mm, 1.9 μm) using a gradient mobile phase system of acetonitrile-water containing 0.1% formic acid. The assay was successfully applied to study the pharmacokinetic behavior of the three analytes in rats after oral and intravenous administration of a mixture of saponins (hederacoside C, Hederacoside D, and ɑ-hederin). Further research was performed to compare the pharmacokinetic behavior of the three analytes after the oral administration of a mixture of saponins and an extract of saponins from Hedera helix, and results showed that double peaks were evident on concentration-time profile for each of the three saponins.
CONCLUSIONS:
The difference in the pharmacokinetic characteristics of three saponins between a mixture of saponins and an extract of saponins from Hedera helix was found in rat, which would be beneficial for the preclinical research and clinical use of Hedera helix.
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CFN91669Celosin H1623405-28-6957.06C47H72O20
CFN91061Celosin I1807732-38-21103.2C53H82O24
CFN91152Celosin J1623405-29-71235.3C58H90O28
CFN95176Polygalasaponin XXXV184479-28-51351.5C63H98O31
CFN90600Onjisaponin B35906-36-61573.69C75H112O35
CFN90728Polygalasaponin XXXI79103-90-51589.67C75H112O36
CFN95117Polygalasaponin XLIX1033593-12-21399.47C64H102O33
CFN91698Ilexoside XLVIII129095-76-7811.0C42H66O15
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