Science | Nature | Cell | View More
Natural Products
Heveaflavone
Heveaflavone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Heveaflavone
Price:
CAS No.: 23132-13-0
Catalog No.: CFN98236
Molecular Formula: C33H24O10
Molecular Weight: 580.6 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Source: The herbs of Selaginella tamariscina (P. Beauv.) Spring
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Tokyo Woman's Christian University (Japan)
  • Universita' Degli Studi Di Cagl... (Italy)
  • Kazusa DNA Research Institute (Japan)
  • Institute of Bioorganic Chemist... (Poland)
  • University of Lodz (Poland)
  • Institute of Pathophysiology Me... (Austria)
  • Sanford Burnham Medical Researc... (USA)
  • Shanghai Institute of Biochemis... (China)
  • Universidad de Ciencias y Artes... (Mexico)
  • University of British Columbia (Canada)
  • University of Maryland School o... (USA)
  • More...
Package
Featured Products
Sarsasapogenin

Catalog No: CFN99779
CAS No: 126-19-2
Price: $40/20mg
Coumestrol

Catalog No: CFN96040
CAS No: 479-13-0
Price: $178/10mg
Astilbin

Catalog No: CFN98371
CAS No: 29838-67-3
Price: $30/20mg
Moschamine

Catalog No: CFN94006
CAS No: 68573-23-9
Price: $218/5mg
Hirsuteine

Catalog No: CFN90615
CAS No: 35467-43-7
Price: $268/5mg
3-O-Acetyl-11-keto-beta-boswellic ...

Catalog No: CFN90531
CAS No: 67416-61-9
Price: $80/20mg
Cardamonin

Catalog No: CFN99890
CAS No: 19309-14-9
Price: $40/20mg
Soyasaponin Ab

Catalog No: CFN90773
CAS No: 118194-13-1
Price: $ / mg
Isorhoifolin

Catalog No: CFN98927
CAS No: 552-57-8
Price: $388/20mg
Ferruginol

Catalog No: CFN92178
CAS No: 514-62-5
Price: $ / mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Heveaflavone has anti-proliferation effects, it shows moderate Topoisomerase I inhibitory activity. It also possesses a good antioxidant activity via its DPPH free radical scavenging.
Targets: Topoisomerase
In vitro:
Phytochem Anal. 2014 Mar-Apr;25(2):127-33.
Preparative isolation of six anti-tumour biflavonoids from Selaginella doederleinii Hieron by high-speed counter-current chromatography.[Pubmed: 24115163]
Biflavonoids are the primary constituents of Selaginella doederleinii Hieron, to which different bioactivities have been attributed, including anti-cancer, anti-inflammatory, anti-oxidant, anti-fungal and anti-virus activity. However, effective methods for separation of these compounds are not currently available. To develop a high performance and bioassay-guided method for preparative isolation of biflavonoids from S. doederleini via high-speed counter-current chromatography (HSCCC).
METHODS AND RESULTS:
The anti-proliferation effects of four fractions (70% ethanol, petroleum ether, dichloromethane and acetic ether extracts) of S. doederleinii on five human cancer cells were monitored. The dichloromethane and acetic ether extracts showed good cytotoxicities to the studied cancer cell lines, guiding the subsequent separation. Two solvent systems composed of n-hexane:ethyl acetate:methanol:water (1:2:1.5:1.5, v/v) and n-hexane:ethyl acetate:methanol:water (3:2:3:2, v/v) were developed for separation of the active fractions, respectively. Identification of the biflavonoids was performed by EI-MS(n) , (1) H- and (13) C-NMR. Under the optimised conditions, 12.6 mg amentoflavone (91.4%), 6.6 mg robustaflavone (90.4%), 7.5 mg 2'', 3''-dihydro-3', 3'''-biapigenin (98.2%) and 7.3 mg 3', 3'''-binaringenin (90.3%) from acetic ether extract (500 mg) and 6.3 mg Heveaflavone (93.5%) and 5.3 mg 7, 4', 7'', 4'''-tetra-O-methyl-amentoflavone (94.5%) from dichloromethane extract (200 mg) were obtained, respectively. The anti-proliferation effects of the six biflavonoids on the five human cancer cells were further verified.
CONCLUSIONS:
The study provides methodological references for simultaneously preparative isolation of several bioactive biflavones from the herbal family of Selaginella. It is the first report discovering 2'', 3''-dihydro-3', 3'''-biapigenin and 3', 3'''-binaringenin from this herb and describing their cytotoxicities to human cancer cell lines.
J Tradit Complement Med. 2012 Jul;2(3):220-6.
Naturally Occurring Cytotoxic [3'→8″]-Biflavonoids from Podocarpus nakaii.[Pubmed: 24716136]

METHODS AND RESULTS:
Bioassay-guided fractionation of the EtOH extract of the dried twigs of Podocarpus nakaii Hayata (Podocarpaceae), endemic plant in Taiwan has resulted in isolation of four [3'→8″]-biflavonoid derivatives, amenotoflavone (AF), podocarpusflavone-A (PF), II-4″,I-7-dimethoxyamentoflavone (DAF), and Heveaflavone (HF). Their structures were determined by physical and extensive spectroscopic analyses such as (1)H, (13)C, (1)H-(1)H COSY, HMQC, and HMBC, as well as comparison with literature values.
CONCLUSIONS:
Compounds PF and DAF showed significant inhibitions against DLD, KB, MCF-7, HEp-2 tumor cell lines (ED50 ca. 4.56-16.24 μg/mL) and induced cell apoptosis in MCF-7 via mainly sub-G1/S phase arrest. Furthermore, these compounds exhibited moderate Topoisomerase I inhibitory activity.
Heveaflavone Description
Source: The herbs of Selaginella tamariscina (P. Beauv.) Spring
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Isoeuphorbetin

Catalog No: CFN95207
CAS No: 50677-55-9
Price: $318/5mg
Euphorbia factor L24

Catalog No: CFN95334
CAS No: 1613700-13-2
Price: $318/5mg
Quercetin 3,5-O-diglucoside

Catalog No: CFN95486
CAS No: 206257-35-4
Price: $318/5mg
13(S)-Hydroxyoctadeca-9(Z),11(E)-d...

Catalog No: CFN95307
CAS No: 18104-45-5
Price: $318/10mg
Astin B

Catalog No: CFN95188
CAS No: 151201-76-2
Price: $318/10mg
Malabaricone C

Catalog No: CFN95475
CAS No: 63335-25-1
Price: $318/10mg
(E)-6-O-(p-coumaroyl)scandoside me...

Catalog No: CFN95192
CAS No: 83946-90-1
Price: $218/10mg
5-Hydroxy-4a,8-dimethyl-3-methylen...

Catalog No: CFN95522
CAS No: 114579-31-6
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7224 mL 8.6118 mL 17.2236 mL 34.4471 mL 43.0589 mL
5 mM 0.3445 mL 1.7224 mL 3.4447 mL 6.8894 mL 8.6118 mL
10 mM 0.1722 mL 0.8612 mL 1.7224 mL 3.4447 mL 4.3059 mL
50 mM 0.0344 mL 0.1722 mL 0.3445 mL 0.6889 mL 0.8612 mL
100 mM 0.0172 mL 0.0861 mL 0.1722 mL 0.3445 mL 0.4306 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Int J Anal Chem. 2015;2015:849769.
Rapid Screening and Structural Characterization of Antioxidants from the Extract of Selaginella doederleinii Hieron with DPPH-UPLC-Q-TOF/MS Method.[Pubmed: 25792983]

METHODS AND RESULTS:
2,2-Diphenyl-1-picrylhydrazyl-ultra-high performance liquid chromatography-Q-time-of-flight mass spectrometry (DPPH-UPLC-Q-TOF/MS), as a rapid and efficient means, now was used for the first time to screen antioxidants from Selaginella doederleinii. The nine biflavone compounds were screened as potential antioxidants. The biflavones were structurally identified and divided into the three types, that is, amentoflavone-type, robustaflavone-type, and hinokiflavone-type biflavonoids. Among the compounds bilobetin (3) and putraflavone (8) were found from Selaginella doederleinii for the first time and others including amentoflavone (1), robustaflavone (2), 4'-methoxy robustaflavone (4), podocarpusflavone A (5), hinokiflavone (6), ginkgetin (7), and Heveaflavone (9) were identified previously in the plant. Moreover, nine biflavones possessed a good antioxidant activity via their DPPH free radical scavenging.
CONCLUSIONS:
It demonstrates that DPPH-UPLC-Q-TOF/MS exhibits strong capacity in separation and identification for small molecule. The method is suitable for rapid screening of antioxidants without the need for complicated systems and additional instruments.
Sarsasapogenin

Catalog No: CFN99779
CAS No: 126-19-2
Price: $40/20mg
Coumestrol

Catalog No: CFN96040
CAS No: 479-13-0
Price: $178/10mg
Astilbin

Catalog No: CFN98371
CAS No: 29838-67-3
Price: $30/20mg
Moschamine

Catalog No: CFN94006
CAS No: 68573-23-9
Price: $218/5mg
Hirsuteine

Catalog No: CFN90615
CAS No: 35467-43-7
Price: $268/5mg
3-O-Acetyl-11-keto-beta-boswellic ...

Catalog No: CFN90531
CAS No: 67416-61-9
Price: $80/20mg
Cardamonin

Catalog No: CFN99890
CAS No: 19309-14-9
Price: $40/20mg
Soyasaponin Ab

Catalog No: CFN90773
CAS No: 118194-13-1
Price: $ / mg
Isorhoifolin

Catalog No: CFN98927
CAS No: 552-57-8
Price: $388/20mg
Ferruginol

Catalog No: CFN92178
CAS No: 514-62-5
Price: $ / mg
Tags: buy Heveaflavone | Heveaflavone supplier | purchase Heveaflavone | Heveaflavone cost | Heveaflavone manufacturer | order Heveaflavone | Heveaflavone distributor