Structure Identification: |
Chem Biodivers. 2008 Jul;5(7):1369-76. | Two new triterpene saponins from the anti-inflammatory saponin fraction of Ilex pubescens root.[Pubmed: 18649303] | The saponin fraction from the ethanolic extracts of the root of Ilex pubescens Hook. et Arn. (Ilexaceae) was found to exhibit potent anti-inflammatory effects on carrageenan-induced paw edema in rats.
METHODS AND RESULTS:
Two novel triterpene saponins, pubescenoside C and pubescenoside D (1 and 2, resp.), together with five known saponins were isolated from this saponin fraction. The structures of 1 and 2 were elucidated as (20beta)-3-O-[beta-D-glucopyranosyl-(1-->2)-beta-D-xylopyranosyl]ursa-12,18-dien-28-oic acid 28-O-beta-D-glucopyranosyl ester, and (20beta)-3-O-[alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranosyl-(1-->2)-beta-D-xylopyranosyl]ursa- 12,18-dien-28-oic acid 28-O-beta-D-glucopyranosyl ester, respectively, on the basis of chemical and spectroscopic data.
CONCLUSIONS:
Five known saponins isolated from the saponin fraction were identified as ilexsaponin B(1), ilexsaponin B(2),ilexsaponin B(3), Ilexsaponin A(1), and chikusetsusaponin IV(a). |
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