Isocurcumenol | CAS:24063-71-6 | Manufacturer ChemFaces

Isocurcumenol

ChemFaces products have been cited in many studies from excellent and top scientific journals

Product Name	Isocurcumenol
Price:	$238 / 20mg
CAS No.:	24063-71-6
Catalog No.:	CFN92618
Molecular Formula:	C₁₅H₂₂O₂
Molecular Weight:	234.3 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The rhizomes of Curcuma wenyujin Y.H.Chen et C.Ling.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $52.6 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Isocurcumenol inhibits 5α-reductase which converts testosterone to dihydrotestosterone (DHT).

Targets:

5α-Reductase

In vivo:

Fitoterapia. 2012 Jul;83(5):864-71.

Anti-androgenic effect of sesquiterpenes isolated from the rhizomes of Curcuma aeruginosa Roxb.[Pubmed: 22465508]

METHODS AND RESULTS:
Six sesquiterpenes: germacrone (1), zederone (2), dehydrocurdione (3), curcumenol (4), zedoarondiol (5) and Isocurcumenol (6) were isolated from rhizomes of Curcuma aeruginosa Roxb. (Zingiberaceae). They inhibited 5α-reductase which converts testosterone to dihydrotestosterone (DHT). Germacrone (1) was the most potent (IC(50)=0.42±0.05 mg/mL). Compound 1 was anti-androgenic in LNCaP cells when proliferation was testosterone-induced. The growth of flank gland of male Syrian hamsters is dependent on circulating androgen and when maintained with testosterone, 1 (3, 30, 100μg) inhibited growth but was ineffective against DHT. The similar activity profile was observed on the 5α-reductase inhibitor, finasteride (100 μg) treatment group. The androgen receptor binding assay showed that 1 did not bind to the androgen receptor.
CONCLUSIONS:
In conclusion, 1 showed anti-androgenic effect on in vitro and in vivo assays. One of the possible mechanisms was inhibition 5α-reductase activity. Thus, 1 is a potential lead compound for treatment of androgen-dependent disorders.

Isocurcumenol Description

Source:	The rhizomes of Curcuma wenyujin Y.H.Chen et C.Ling.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Nat Prod Res. 2014;28(20):1680-4.

Comparative study on the chemical constituents of essential oils from different organs of the Sicilian Kundmannia (Kundmannia sicula L.) DC. (Apiaceae) growing spontaneously in Tunisia.[Pubmed: 25022439]

Essential oils from odorous and volatile compounds possessing several therapeutic benefits are considered of a paramount importance in everyday human life.
METHODS AND RESULTS:
This study deals with a comparative study of essential oils from different parts of an aromatic plant Kundmannia sicula (L.) DC. (Apiaceae) growing in Tunisia. The hydro-distilled essential oils of the leaves and inflorescences with mature seeds (IMS) of K. sicula were analysed for the first time by gas chromatography equipped with flame ionisation detector and gas chromatography coupled with mass spectrometry. Fifty leaves and 47 IMS constituents were identified, accounting for 97.9% and 98.2% of the total oil, respectively.
CONCLUSIONS:
The major compounds identified from the leaves and IMS oils were Isocurcumenol (9.9-10.1%), hexadecanoic acid (9.5-10.9%), spathulenol (6.9-3.4%), 10-epi-γ-eudesmol (6.3-5.5%), α-cubebene (5.9-6.1%) and trans-dihydro occidentalol (52-6.6%). The essential oil consists mainly of oxygenated monoterpenes (50.7-53.2%).

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-proliferation Compound Library Sesquiterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.268 mL	21.3402 mL	42.6803 mL	85.3606 mL	106.7008 mL
5 mM	0.8536 mL	4.268 mL	8.5361 mL	17.0721 mL	21.3402 mL
10 mM	0.4268 mL	2.134 mL	4.268 mL	8.5361 mL	10.6701 mL
50 mM	0.0854 mL	0.4268 mL	0.8536 mL	1.7072 mL	2.134 mL
100 mM	0.0427 mL	0.2134 mL	0.4268 mL	0.8536 mL	1.067 mL

CFN97446	Alismol	87827-55-2	220.4	C₁₅H₂₄O
CFN99775	Alismoxide	87701-68-6	238.37	C₁₅H₂₆O₂
CFN96326	Guaiol	489-86-1	222.4	C₁₅H₂₆O
CFN99634	Teuclatriol	152110-17-3	256.4	C₁₅H₂₈O₃
CFN98560	Atractyloside A	126054-77-1	448.5	C₂₁H₃₆O₁₀
CFN89350	Isonardoperoxide	205248-65-3	266.33	C₁₅H₂₂O₄
CFN92654	Orobanone	78916-35-5	216.3	C₁₅H₂₀O
CFN92652	Zedoarondiol	98644-24-7	252.4	C₁₅H₂₄O₃
CFN92620	Isoprocurcumenol	102130-90-5	234.3	C₁₅H₂₂O₂
CFN92647	Procurcumenol	21698-40-8	234.3	C₁₅H₂₂O₂