| Description: |
Isomartynoside has inhibition against the angiotensin converting enzyme (ACE) activities, the IC 50 value is 505±26.7μg/ml, it may have antihypertensive effect. Isomartynoside also shows obvious anti-fatigue activity. |
| In vitro: |
| J. Ethnopharmacol., 2003, 89(1):151-4. | | Angiotensin converting enzyme inhibitory phenylpropanoid glycosides from Clerodendron trichotomum.[Pubmed: 14522447] |
The stems of Clerodendron trichotomum have been traditionally used for treatment of hypertension in far East Asia including China, Korea, and Japan.
METHODS AND RESULTS:
Bioassay-guided fractionation and purification of the EtOAc-soluble extract of Clerodendron trichotomum afforded acteoside (1), leucosceptoside A (2), martynoside (3), acteoside isomer (4), and Isomartynoside (5). The angiotensin converting enzyme (ACE) activities were significantly inhibited by the addition of these phenylpropanoid glycosides (1-5) in a dose-dependent manner of which IC(50) values were 373+/-9.3 microg/ml, 423+/-18.8 microg/ml, 524+/-28.1 microg/ml, 376+/-15.6 microg/ml, 505+/-26.7 microg/ml, respectively.
CONCLUSIONS:
These results suggest that the antihypertensive effect of Clerodendron trichotomum may be, at least in part, due to ACE inhibitory effect of phenylpropanoid glycosides. |
|
| In vivo: |
| Chinese Traditional & Herbal Drugs, 2014, 45(9):1223-7. | | Phenylpropanoids constituents of Pedicularis dichotoma.[Reference: WebLink] | To study the phenylpropanoid constituents from the whole plants of Pedicularis dichotoma and the anti-fatigue activities in vivo.
METHODS AND RESULTS:
The n-BuOH fraction of 95% ethanol extract from P. dichotoma was separated and purified by silica gel, re-phase and Sephadex LH-20 column chromatography. The structures of the compounds were identified by physicochemical properties and various spectroscopic methods. The compounds were tested on anti-fatigue activity using mice in swimming model. Twelve phenylpropanoid compounds were isolated and purified. Their structures were identified as verbascoside (1), isoverbascoside (2), leucoseptoside A (3), jionoside D (4), martynoside (5), Isomartynoside (6), cis-martynoside (7), citrusin C (8), robustaside B (9), darendoside B (10), zizybeoside I (11), and salidroside (12). Verbascoside could obviously prolong the swimming time of mice.
CONCLUSIONS:
Compounds 1-12 are obtained from the plant for the first time, and compound 11 is reported from the plants of Pedicularis Linn. for the first time. Phenylpropanoids show obvious anti-fatigue activities. |
|
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