Isomeranzin | CAS:1088-17-1 | Manufacturer ChemFaces

Isomeranzin

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Size /Price /Stock	10 mM * 1 mL in DMSO / $79.3 / In-stock
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Description:

Isomeranzin has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathway.

Targets:

NF-kB | ERK

In vivo:

Int Immunopharmacol. 2016 Sep;38:175-85.

Isomeranzin suppresses inflammation by inhibiting M1 macrophage polarization through the NF-κB and ERK pathway.[Pubmed: 27285671 ]

Macrophage polarization plays an important role in inflammation. Regulation of the polarization has been reported to be effective therapeutics for various kinds of inflammatory diseases. The aims of the present study were to investigate the anti-inflammatory property of Isomeranzin isolating from Murraya exotica as well as potential molecular mechanisms.
METHODS AND RESULTS:
Results showed that Isomeranzin specifically reduced the M1 macrophage-associated pro-inflammatory cytokines through down-regulation of NF-κB and ERK signals. Immunoprecipitation and RNA silencing indicated suppression of Isomeranzin in NF-κB activation was relying on the decreasing of TRAF6 ubiquitination. In vivo studies showed Isomeranzin evidently inhibited LPS-induced sepsis for rising survival rate, improving tissue damage and lessening inflammatory cytokines. In accordance with in vitro studies, Isomeranzin significantly blocked expression of p-p65 and p-ERK in lung and liver tissues. Moreover, Isomeranzin ameliorated DSS and TNBS-induced colitis due to its anti-inflammatory effects.
CONCLUSIONS:
Taken together, Isomeranzin suppressed inflammatory diseases by controlling M1 macrophage polarization through the NF-κB and ERK pathway.

Isomeranzin Description

Source:	The peels of Citrus maxima
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Isomeranzin
Price:	$298 / 20mg
CAS No.:	1088-17-1
Catalog No.:	CFN99090
Molecular Formula:	C₁₅H₁₆O₄
Molecular Weight:	260.3 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Source:	The peels of Citrus maxima
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Coumarins Compound Library NF-kB Inhibitor Library ERK Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.8417 mL	19.2086 mL	38.4172 mL	76.8344 mL	96.043 mL
5 mM	0.7683 mL	3.8417 mL	7.6834 mL	15.3669 mL	19.2086 mL
10 mM	0.3842 mL	1.9209 mL	3.8417 mL	7.6834 mL	9.6043 mL
50 mM	0.0768 mL	0.3842 mL	0.7683 mL	1.5367 mL	1.9209 mL
100 mM	0.0384 mL	0.1921 mL	0.3842 mL	0.7683 mL	0.9604 mL

CFN99090	Isomeranzin	1088-17-1	260.3	C₁₅H₁₆O₄
CFN98994	Meranzin hydrate	5875-49-0	278.3	C₁₅H₁₈O₅
CFN99362	8-(3-Ethoxy-2-hydroxy-3-methylbutyl)-7-methoxycoumarin	125072-68-6	306.4	C₁₇H₂₂O₅
CFN89410	Cedrelopsin	19397-28-5	260.28	C₁₅H₁₆O₄
CFN92731	O-Methylcedrelopsin	72916-61-1	274.3	C₁₆H₁₈O₄
CFN99811	Coumurrayin	17245-25-9	274.3	C₁₆H₁₈O₄
CFN97531	Sibiricin	95188-34-4	290.3	C₁₆H₁₈O₅
CFN97454	Isomexoticin	88585-86-8	308.3	C₁₆H₂₀O₆
CFN99097	Murraol	109741-38-0	260.3	C₁₅H₁₆O₄
CFN97693	Casegravol	74474-76-3	276.29	C₁₅H₁₆O₅