Isopimaric acid | CAS:5835-26-7 | Manufacturer ChemFaces

Isopimaric acid

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Description:

Isopimaric acid is active against MDR and MRSA strains of S. aureus which are becoming increasingly resistant to antibiotics, the minimum inhibitory concentrations (MIC) are 32-64 microg/mL . Isopimaric acid is also possible that an antagonistic interaction with reserpine may render the antibiotics inactive.

Targets:

Antifection

In vitro:

Phytother Res. 2005 Jun;19(6):538-42.

Isopimaric acid from Pinus nigra shows activity against multidrug-resistant and EMRSA strains of Staphylococcus aureus.[Pubmed: 16114093]

METHODS AND RESULTS:
The diterpene Isopimaric acid was extracted from the immature cones of Pinus nigra (Arnold) using bioassay-guided fractionation of a crude hexane extract. Isopimaric acid was assayed against multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MIC) were 32-64 microg/mL and compared with a commercially obtained resin acid, abietic acid, with MICs of 64 microg/mL. Resin acids are known to have antibacterial activity and are valued in traditional medicine for their antiseptic properties. These results show that Isopimaric acid is active against MDR and MRSA strains of S. aureus which are becoming increasingly resistant to antibiotics. Both compounds were evaluated for modulation activity in combination with antibiotics, but did not potentiate the activity of the antibiotics tested. However, the compounds were also assayed in combination with the efflux pump inhibitor reserpine, to see if inhibition of the TetK or NorA efflux pump increased their activity. Interestingly, rather than a potentiation of activity by a reduction in MIC, a two to four-fold increase in MIC was seen.
CONCLUSIONS:
It may be that Isopimaric acid and abietic acid are not substrates for these efflux pumps, but it is also possible that an antagonistic interaction with reserpine may render the antibiotics inactive. 1H-NMR of abietic acid and reserpine taken individually and in combination, revealed a shift in resonance of some peaks for both compounds when mixed together compared with the spectra of the compounds on their own. It is proposed that this may be due to complex formation between abietic acid and reserpine and that this complex formation is responsible for a reduction in activity and elevation of MIC.

Isopimaric acid Description

Source:	The herbs of Daemonorops draco Blume
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Isopimaric acid
Price:
CAS No.:	5835-26-7
Catalog No.:	CFN97723
Molecular Formula:	C₂₀H₃₀O₂
Molecular Weight:	302.46 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The herbs of Daemonorops draco Blume
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antibacterial Compound Library Diterpenoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.3062 mL	16.5311 mL	33.0622 mL	66.1244 mL	82.6556 mL
5 mM	0.6612 mL	3.3062 mL	6.6124 mL	13.2249 mL	16.5311 mL
10 mM	0.3306 mL	1.6531 mL	3.3062 mL	6.6124 mL	8.2656 mL
50 mM	0.0661 mL	0.3306 mL	0.6612 mL	1.3225 mL	1.6531 mL
100 mM	0.0331 mL	0.1653 mL	0.3306 mL	0.6612 mL	0.8266 mL

CFN98805	Rosenonolactone	508-71-4	316.4	C₂₀H₂₈O₃
CFN95442	Orthosiphol A	142741-25-1	676.8	C₃₈H₄₄O₁₁
CFN95447	Neoorthosiphol A	243448-72-8	692.8	C₃₈H₄₄O₁₂
CFN97214	15-Isopimarene-8,18-diol	73002-86-5	306.5	C₂₀H₃₄O₂
CFN92899	Toonaciliatin M	93930-04-2	320.47	C₂₀H₃₂O₃
CFN97003	8(14),15-Isopimaradiene-3,18-diol	59219-64-6	304.5	C₂₀H₃₂O₂
CFN92876	Hugorosenone	217096-49-6	302.4	C₂₀H₃₀O₂
CFN96300	Yucalexin P-17	119642-82-9	318.5	C₂₀H₃₀O₃
CFN90861	Continentalic acid	19889-23-7	302.5	C₂₀H₃₀O₂
CFN99382	Pimaric acid	127-27-5	302.5	C₂₀H₃₀O₂