Isorhamnetin-3-O-neohespeidoside | CAS:55033-90-4

Isorhamnetin-3-O-neohespeidoside

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Size /Price /Stock	10 mM * 1 mL in DMSO / $30.8 / In-stock
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Description:

Isorhamnetin 3-O-neohesperoside is the major active substance of Puhuang, a traditional herb medicine widely used in clinical practice to tackle many chronic diseases. It has signiﬁcant biological and pharmacological activities, including antioxidant, antiatherogenic and antimicrobial effects.

In vitro:

J Sep Sci . 2019 Jul;42(14):2426-2434.

A rapid and efficient extraction method based on industrial MCM-41-miniaturized matrix solid-phase dispersion extraction with response surface methodology for simultaneous quantification of six flavonoids in Pollen typhae by ultra-high-performance liquid chromatography[Pubmed: 31077572]

Abstract An industrial MCM-41-miniaturized matrix solid-phase dispersion extraction coupled with response surface methodology was explored to determine L-epicatechin, typhaneoside, Isorhamnetin-3-O-neohespeidoside, naringenin, kaempferol, and isorhamnetin in Pollen typhae by ultra-high performance liquid chromatography connected to a photodiode array detection. Several variables were optimized in detail, including mesh number of sieve, type of adsorbent, mass ratio of sample to adsorbent, grinding time, methanol concentration, and elution volume. Central composite design was applied to optimize the best conditions for the maximum yields of the total flavonoids. The results displayed a good linear relationship (R > 0.9992) and the recoveries ranged from 92.9 to 103% (RSD < 4.53%) of the six flavonoids. The optimal method with high efficiency and low consumption was obviously better than heating reflux and ultrasonic extraction. It was proven that the developed industrial MCM-41-miniaturized matrix solid-phase dispersion extraction coupled with simple ultra-high performance liquid chromatography method could be a rapid and efficient tool for extraction and determination of flavonoids in natural products. Keywords: MCM-41; miniaturized matrix solid-phase dispersion extraction; response surface methodology; traditional Chinese medicine; ultra-high-performance liquid chromatography.

Isorhamnetin-3-O-neohespeidoside Description

Source:	The barks of Rhamnus purshiana
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jan 1;974:131-7.

Measurement of hydroxysafflor yellow A in human urine by liquid chromatography-tandem mass spectrometry.[Pubmed: 25463208]

METHODS AND RESULTS:
A rapid and specific high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed for the quantification of hydroxysafflor yellow A (HSYA) in human urine with Isorhamnetin-3-O-neohespeidoside as internal standard (IS). HSYA and IS were extracted from urine samples by simple solid-phase extraction and separated on an Agilent Zorbax SB C18 column (4.6 mm × 150 mm, 5 μm) with the mobile phase of 0.2 mM ammonium acetate: methanol (30/70, v/v) at a flow rate of 0.4 mL/min. Polar endogenous interferences eluted in 0.1-2.5 min were switched into waste channel by the Valve Valco, to reduce the possible matrix effect for MS detection in each run. The MS detection of analytes was performed on a tandem mass spectrometer equipped with an electrospray ionization source in negative mode using multiple-reaction monitoring. The MS/MS ion transitions monitored were m/z 611.3→491.2 for HSYA and m/z 623.2→299.2 for IS. The method was fully validated for selectivity, sensitivity, linearity, precision, accuracy, recovery, matrix effect and stability, and then was applied to the urinary excretion study of injectable powder of pure HSYA in healthy Chinese volunteers for the first time.
CONCLUSIONS:
The results suggested that urine was the main excretion way of HSYA in healthy volunteers, further demonstrating the feasibility and necessity of our current method.

Product Name	Isorhamnetin-3-O-neohespeidoside
Price:	$60 / 20mg
CAS No.:	55033-90-4
Catalog No.:	CFN99744
Molecular Formula:	C₂₈H₃₂O₁₆
Molecular Weight:	624.54 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Source:	The barks of Rhamnus purshiana
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6012 mL	8.0059 mL	16.0118 mL	32.0236 mL	40.0295 mL
5 mM	0.3202 mL	1.6012 mL	3.2024 mL	6.4047 mL	8.0059 mL
10 mM	0.1601 mL	0.8006 mL	1.6012 mL	3.2024 mL	4.0029 mL
50 mM	0.032 mL	0.1601 mL	0.3202 mL	0.6405 mL	0.8006 mL
100 mM	0.016 mL	0.0801 mL	0.1601 mL	0.3202 mL	0.4003 mL

CFN95494	Isorhamnetin-3-O-rutinoside-7-O-glucoside	55481-91-9	786.7	C₃₄H₄₂O₂₁
CFN91845	Isorhamnetin 3-O-beta-D-glucose-7-O-beta-D-gentiobioside	60778-00-9	802.7	C₃₄H₄₂O₂₂
CFN90735	Isorhamnetin 3-sophoroside-7-rhamnoside	41328-75-0	786.68	C₃₄H₄₂O₂₁
CFN91697	Limocitrin 3-O-beta-D-glucopyranoside	38836-51-0	508.4	C₂₃H₂₄O₁₃
CFN91693	Limocitrin-3-O-rutinoside	79384-27-3	654.6	C₂₉H₃₄O₁₇
CFN91459	Limocitrin-3-O-beta-D-sophoroside	114882-19-8	670.6	C₂₉H₃₄O₁₈
CFN99757	Isorhamnetin-3-O-beta-D-Glucoside	5041-82-7	478.40	C₂₂H₂₂O₁₂
CFN93036	Isorhamnetin 3-O-galactoside	6743-92-6	478.40	C₂₂H₂₂O₁₂
CFN95116	Rhamnetin 3-galactoside	62858-07-5	478.4	C₂₂H₂₂O₁₂
CFN90568	Isorhamnetin 3-glucuronide	36687-76-0	492.39	C₂₂H₂₀O₁₃