Isotaxiresinol | CAS:26194-57-0 | Manufacturer ChemFaces

Isotaxiresinol

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Description:

Isotaxiresinol prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis induced by TNF-alpha. Isotaxiresinol may be useful for treatment of postmenopausal osteoporosis, especially for prevention of bone fracture induced by estrogen deficiency.

Targets:

IFN-γ | TNF-α

In vivo:

Phytomedicine. 2006 Jan;13(1-2):37-42.

In vivo anti-osteoporotic activity of isotaxiresinol, a lignan from wood of Taxus yunnanensis.[Pubmed: 16360931]

METHODS AND RESULTS:
Isotaxiresinol, the main lignan isolated from the water extract of wood of Taxus yunnanensis, was investigated for its effect on bone loss, on serum biochemical markers for bone remodeling and on uterine tissue, using ovariectomized (OVX) rats as the model of postmenopausal osteoporosis. After oral administration of Isotaxiresinol (50 and 100mg/kg/d) for 6 weeks, bone mineral content (BMC) and bone mineral density (BMD) in total and cortical bones were increased as compared to those of OVX control rats, and decreases of three bone strength indexes induced by OVX surgery were prevented. Serum biochemical markers for bone remodeling revealed that Isotaxiresinol slightly increased bone formation and significantly inhibited bone resorption without side effect on uterine tissue.
CONCLUSIONS:
These results suggest that Isotaxiresinol may be useful for treatment of postmenopausal osteoporosis, especially for prevention of bone fracture induced by estrogen deficiency.

Isotaxiresinol Description

Source:	The branches of Taxus wallichiana
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Life Sci. 2004 Apr 16;74(22):2781-92.

Secoisolariciresinol and isotaxiresinol inhibit tumor necrosis factor-alpha-dependent hepatic apoptosis in mice.[Pubmed: 15043992]

METHODS AND RESULTS:
The effects of secoisolariciresinol (1) and Isotaxiresinol (2), two major lignans isolated from the wood of Taxus yunnanensis, on tumor necrosis factor-alpha (TNF-alpha)-dependent hepatic apoptosis induced by D-galactosamine (d-GalN)/lipopolysaccharide (LPS) were investigated in mice.Pre-administration of 1 or Isotaxiresinol (50, 10 mg/kg, i.p.) 12 and 1 h before d-GalN/LPS significantly reduced DNA fragmentation and prevented chromatin condensation, apoptotic body formation and hepatitis. Pre-treatment with 1 or Isotaxiresinol significantly inhibited the elevation of serum TNF-alpha and IFN-gamma levels.
CONCLUSIONS:
These results indicated that 1 and Isotaxiresinol prevent d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis induced by TNF-alpha.

Product Name	Isotaxiresinol
Price:
CAS No.:	26194-57-0
Catalog No.:	CFN97771
Molecular Formula:	C₁₉H₂₂O₆
Molecular Weight:	346.38 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The branches of Taxus wallichiana
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Hepatoprotective Compound Library Anti-osteoporosis Compound Library Lignans Compound Library TNF-α Inhibitor Library IFN-γ Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.887 mL	14.435 mL	28.87 mL	57.7401 mL	72.1751 mL
5 mM	0.5774 mL	2.887 mL	5.774 mL	11.548 mL	14.435 mL
10 mM	0.2887 mL	1.4435 mL	2.887 mL	5.774 mL	7.2175 mL
50 mM	0.0577 mL	0.2887 mL	0.5774 mL	1.1548 mL	1.4435 mL
100 mM	0.0289 mL	0.1444 mL	0.2887 mL	0.5774 mL	0.7218 mL

CFN99605	7,8,9,9-Tetradehydroisolariciresinol	145918-59-8	356.4	C₂₀H₂₀O₆
CFN96448	Vitedoin A	819861-40-0	356.37	C₂₀H₂₀O₆
CFN95403	(-)-5'-Methoxyisolariciresinol 3alpha-O-beta-glucopyranoside	143236-03-7	552.6	C₂₇H₃₆O₁₂
CFN99488	(+)-Lyoniresinol	14464-90-5	420.5	C₂₂H₂₈O₈
CFN98451	Lyoniside	34425-25-7	552.6	C₂₇H₃₆O₁₂
CFN97964	(+)-Lyoniresinol 9'-O-glucoside	87585-32-8	582.6	C₂₈H₃₈O₁₃
CFN96732	(-)-Lyoniresinol 9'-O-glucoside	143236-02-6	582.59	C₂₈H₃₈O₁₃
CFN89146	Nudiposide	62058-46-2	552.57	C₂₇H₃₆O₁₂
CFN97774	Isotaxiresinol 9,9'-acetonide	252333-72-5	386.44	C₂₂H₂₆O₆
CFN96185	Cycloolivil	3064-05-9	376.4	C₂₀H₂₄O₇