Kauran-16,17-diol (ent-Kauran-16beta,17-diol) | CAS:16836-31-0

Kauran-16,17-diol (ent-Kauran-16beta,17-diol)

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Description:

Kauran-16,17-diol (ent-Kauran-16β,17-diol),a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages

In vitro:

Apoptosis. 2011 Dec;16(12):1245-1252

The natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells[Pubmed: 21850486]

ent-Kauranes are diterpene-type compounds commonly found in most plant species, especially from the Euphorbiaceae family. These compounds have been studied due to their anti-inflammatory and anti-tumor properties. Regulation of apoptosis, or programmed cell death, is commonly bypassed by tumoral cells, giving rise to uncontrolled proliferating cells, which eventually become carcinogenic. In a previous work, we showed that both mRNA and protein expression levels of the antiapoptotic gene Bcl-2 are reduced in MCF-7 cancer cells by the effect of the natural diterpene ent-16β-17α-dihydroxykaurane (DHK). This effect was not directly associated with the inactivation of NF-κB, as has been shown with other diterpenes compounds. Herein, we report that DHK is dissociating the Ap2α-Rb activating complex, affecting its binding ability for the Bcl-2 gene promoter. These events down-regulate Bcl-2 and is temporally accompanied by the induction of E2F1 and its target pro-apoptotic gene Puma. Disruption of the Rb-Ap2α activation complex was corroborated by chromatin immunoprecipitation and protein immunolocalization, which also revealed that Ap2α sorts out from the nucleus and relocalizes in the cell periphery. Taken together, our study confirms the regulation of Bcl-2 gene transcription by the Ap2α-Rb complex and describes a singular protein relocalization for Ap2α induced by DHK, implicating a new potential therapeutic target to differentially onset apoptosis in tumor cells.

Kauran-16,17-diol (ent-Kauran-16beta,17-diol) Description

Source:	The herbs of Croton laevigatus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Kauran-16,17-diol (ent-Kauran-16beta,17-diol)
Price:	$288 / 10mg
CAS No.:	16836-31-0
Catalog No.:	CFN91681
Molecular Formula:	C₂₀H₃₄O₂
Molecular Weight:	306.5 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The herbs of Croton laevigatus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.2626 mL	16.3132 mL	32.6264 mL	65.2529 mL	81.5661 mL
5 mM	0.6525 mL	3.2626 mL	6.5253 mL	13.0506 mL	16.3132 mL
10 mM	0.3263 mL	1.6313 mL	3.2626 mL	6.5253 mL	8.1566 mL
50 mM	0.0653 mL	0.3263 mL	0.6525 mL	1.3051 mL	1.6313 mL
100 mM	0.0326 mL	0.1631 mL	0.3263 mL	0.6525 mL	0.8157 mL

CFN89423	Kanshone B	115370-61-1	266.33	C₁₅H₂₂O₄
CFN91851	Rheumone B	2095596-67-9	448.4	C₂₂H₂₄O₁₀
CFN92432	8-Hydroxypinoresinol	81426-17-7	374.4	C₂₀H₂₂O₇
CFN96287	Gopherenediol	916236-79-8	306.5	C₂₀H₃₄O₂