Kazinol U | CAS:1238116-48-7 | Manufacturer ChemFaces

Kazinol U

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Gentisic acid

Catalog No: CFN92451
CAS No: 490-79-9
Price: $40/20mg

Luteollin 5-glucoside

Catalog No: CFN98568
CAS No: 20344-46-1
Price: $ / mg

(+)-Lyoniresinol 9'-O-glucoside

Catalog No: CFN97964
CAS No: 87585-32-8
Price: $318/10mg

Vanillin

Catalog No: CFN90463
CAS No: 121-33-5
Price: $30/20mg

Epicatechin

Catalog No: CFN98781
CAS No: 490-46-0
Price: $40/20mg

Isorhamnetin

Catalog No: CFN98735
CAS No: 480-19-3
Price: $60/20mg

Astrasieversianin VII

Catalog No: CFN90648
CAS No: 86764-11-6
Price: $238/10mg

Methyl caffeate acid

Catalog No: CFN95561
CAS No: 3843-74-1
Price: $ / mg

1-Deoxynojirimycin

Catalog No: CFN99933
CAS No: 19130-96-2
Price: $30/20mg

Ginkgolic acid C15:1

Catalog No: CFN90161
CAS No: 22910-60-7
Price: $118/20mg

Description:

Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-activity of estrogen receptor, transcriptional activity of estrogen -responsive element-reporter genes, it may have beneficial effects in the treatment of menopausal symptoms.

Targets:

Estrogen receptor | NF-kB | IkB | NO | NOS | IFN-γ | IL Receptor | IKK | Progestogen receptor

In vitro:

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3764-7.

New estrogenic compounds isolated from Broussonetia kazinoki.[Pubmed: 20493686 ]

METHODS AND RESULTS:
Two new and two known compounds were identified as estrogenic constituents from Broussonetia kazinoki. Their structures were elucidated as broussonin A (1), tupichinol C (2), Kazinol U (3), and (+)-(2R) kazinol I (4). They showed estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. They also control the cellular gene expression levels of estrogen-responsive genes.
CONCLUSIONS:
Phytoestrogens from B. kazinoki may have beneficial effects in the treatment of menopausal symptoms.

Kazinol U Description

Source:	The barks of Broussonetia papyrifera.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Biol Pharm Bull. 2011;34(7):1026-31.

A prenylated flavan from Broussonetia kazinoki prevents cytokine-induced β-cell death through suppression of nuclear factor-κB activity.[Pubmed: 21720008]

The generation of nitric oxide (NO) via inducible NO synthase (iNOS) and reactive oxygen species plays a key role in cytokine-mediated pancreatic β-cell damage. Oxidative stress due to reactive oxygen species activates the nuclear factor-κB (NF-κB) transcription factor, which regulates iNOS expression. In this regard, suppression of the NF-κB pathway is a novel strategy for protecting β-cells from damage.
METHODS AND RESULTS:
This study was performed to explore the effects of Kazinol U, a prenylated flavan from Broussonetia kazinoki, on the NF-κB activation pathway in interleukin-1β (IL-1β)- and interferon-γ (IFN-γ)-treated β-cells. The cytotoxic effects of cytokines were completely abolished when RINm5F cells or islets were pretreated with Kazinol U. Kazinol U inhibited the nuclear translocation and DNA binding of NF-κB subunits, which correlated with the inhibitory effects on IκB kinase (IKK) phosphorylation and IκBα degradation. In addition, Kazinol U suppressed NO and hydrogen peroxide production and apoptotic cell death by cytokines in RINm5F cells. The protective effects of Kazinol U were further demonstrated by normal insulin secretion of cytokine-treated islets in response to glucose.
CONCLUSIONS:
Taken together, these results suggest that using Kazinol U to block the NF-κB pathway in pancreatic β-cells reduces cell damage. Therefore, Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes.

Product Name	Kazinol U
Price:
CAS No.:	1238116-48-7
Catalog No.:	CFN97839
Molecular Formula:	C₂₀H₂₂O₄
Molecular Weight:	326.39 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The barks of Broussonetia papyrifera.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-diabetic Compound Library Estrogenic effect Compound Library Flavonoids Compound Library Progestogen receptor Inhibitor Library NOS Inhibitor Library NO Inhibitor Library NF-kB Inhibitor Library IL Receptor Inhibitor Library IKK Inhibitor Library IkB Inhibitor Library IFN-γ Inhibitor Library Estrogen receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0638 mL	15.3191 mL	30.6382 mL	61.2764 mL	76.5955 mL
5 mM	0.6128 mL	3.0638 mL	6.1276 mL	12.2553 mL	15.3191 mL
10 mM	0.3064 mL	1.5319 mL	3.0638 mL	6.1276 mL	7.6595 mL
50 mM	0.0613 mL	0.3064 mL	0.6128 mL	1.2255 mL	1.5319 mL
100 mM	0.0306 mL	0.1532 mL	0.3064 mL	0.6128 mL	0.766 mL

CFN92674	2H-1-Benzopyran-5-ol	770729-34-5	286.3	C₁₇H₁₈O₄
CFN96531	2',4'-Dihydroxy-7-methoxy-8-prenylflavan	331954-16-6	340.42	C₂₁H₂₄O₄
CFN98606	7,4'-Dihydroxy-3'-prenylflavan	376361-96-5	310.4	C₂₀H₂₂O₃
CFN97839	Kazinol U	1238116-48-7	326.39	C₂₀H₂₂O₄
CFN92431	Kazinol A	99624-28-9	394.5	C₂₅H₃₀O₄
CFN97569	Kazinol B	99624-27-8	392.5	C₂₅H₂₈O₄
CFN97811	7,3'-Dihydroxy-4'-methoxyflavan	162290-05-3	272.30	C₁₆H₁₆O₄
CFN96480	Trilepisflavan	1443218-16-3	286.32	C₁₇H₁₈O₄
CFN99264	3',4',7-Trimethoxyflavan	116384-26-0	300.4	C₁₈H₂₀O₄
CFN96528	7,4'-Dihydroxy-8-methylflavan	82925-55-1	256.30	C₁₆H₁₆O₃