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Kolavenol
Kolavenol
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Kolavenol
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CAS No.: 19941-83-4
Catalog No.: CFN97792
Molecular Formula: C20H34O
Molecular Weight: 290.49 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The herbs of Eupatorium adenophora
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Kolavenol shows a trypanocidal activity with an IC50 value of 2.5 microg/ml (8.6 microM) against Trypanosoma brucei rhodesiense, the causing agent of the acute form of human African trypanosomiasis.
Targets: Antifection
In vitro:
J Ethnopharmacol. 1998 Jul;61(3):179-83.
Bioassay-guided isolation of a diastereoisomer of kolavenol from Entada abyssinica active on Trypanosoma brucei rhodesiense.[Pubmed: 9705008 ]

METHODS AND RESULTS:
Bioassay-guided fractionation of the dichloromethane rootbark extract of Entada abyssinica (Leguminosae), a plant used by traditional healers in Uganda for the treatment of sleeping sickness, led to the isolation of a diastereoisomer of the clerodane type diterpene Kolavenol.
CONCLUSIONS:
This is the first report on this compound. It showed a trypanocidal activity with an IC50 value of 2.5 microg/ml (8.6 microM) against Trypanosoma brucei rhodesiense, the causing agent of the acute form of human African trypanosomiasis.
Kolavenol Description
Source: The herbs of Eupatorium adenophora
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4425 mL 17.2123 mL 34.4246 mL 68.8492 mL 86.0615 mL
5 mM 0.6885 mL 3.4425 mL 6.8849 mL 13.7698 mL 17.2123 mL
10 mM 0.3442 mL 1.7212 mL 3.4425 mL 6.8849 mL 8.6061 mL
50 mM 0.0688 mL 0.3442 mL 0.6885 mL 1.377 mL 1.7212 mL
100 mM 0.0344 mL 0.1721 mL 0.3442 mL 0.6885 mL 0.8606 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN97792Kolavenol19941-83-4290.49C20H34O
CFN978322-Oxokolavenol130395-82-3304.47C20H32O2
CFN9698416-Oxocleroda-3,13E-dien-15-oic acid117620-72-1318.45C20H30O3
CFN98262Monomethyl kolavate24513-41-5348.5 C21H32O4
CFN99325Scutebata E1207181-61-0520.6 C28H40O9
CFN99326Scutebata F1207181-62-1555.6 C30H37NO9
CFN99327Scutebata G1207181-63-2679.8 C40H41NO9
CFN969946-O-Nicotinoylscutebarbatine G1206805-30-2576.64C32H36N2O8
CFN96705Scutebarbatine W1312716-25-8575.65C33H37NO8
CFN977832-Oxokolavelool221466-41-7304.47C20H32O2
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