Science | Nature | Cell | View More
Natural Products
Kushenol C
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Kushenol C
Price: $468 / 10mg
CAS No.: 99119-73-0
Catalog No.: CFN92391
Molecular Formula: C25H26O7
Molecular Weight: 438.5 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Source: The roots of Sophora flavescens Ait.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $304.2 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Cincinnati (USA)
  • Donald Danforth Plant Science C... (USA)
  • University of Medicine and Phar... (Romania)
  • University of Padjajaran (Indonesia)
  • University of Hull (United Kingdom)
  • University of Melbourne (Australia)
  • Florida A&M University (USA)
  • Center for protein Engineering ... (Belgium)
  • Leibniz-Institut für Pflanzenb... (Germany)
  • Chungnam National University (Korea)
  • University of Parma (Italy)
  • More...
Package
Featured Products
Cucurbitacin B

Catalog No: CFN99129
CAS No: 6199-67-3
Price: $70/20mg
Panaxadiol

Catalog No: CFN99981
CAS No: 19666-76-3
Price: $40/20mg
Kobophenol A

Catalog No: CFN92530
CAS No: 124027-58-3
Price: $318/10mg
Elemicin

Catalog No: CFN90685
CAS No: 487-11-6
Price: $30/20mg
Ginkgolide C

Catalog No: CFN99639
CAS No: 15291-76-6
Price: $30/20mg
Ganoderic acid H

Catalog No: CFN92056
CAS No: 98665-19-1
Price: $318/10mg
Dehydropachymic acid

Catalog No: CFN92742
CAS No: 77012-31-8
Price: $268/10mg
Vomifoliol

Catalog No: CFN98245
CAS No: 23526-45-6
Price: $ /
Demethylzeylasteral

Catalog No: CFN90136
CAS No: 107316-88-1
Price: $40/20mg
Isosilybin

Catalog No: CFN90260
CAS No: 72581-71-6
Price: $138/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). Kushenol C shows antimicrobial activity against Staphylococcus aureus and Streptococcus mutans. Kushenol C may be potent preventive and therapeutic candidates for Alzheimer's disease, it (IC(50) 5.45 microM) can inhibit beta-site APP cleaving enzyme 1 (BACE1) activities.
Targets: ROS | BACE1 | Antifection | SGLT2 | NF-κB
In vitro:
Biol. Pharm. Bull., 2008, 31(5):908-15.
Re-evaluation of the antioxidant prenylated flavonoids from the roots of Sophora flavescens.[Pubmed: 18451517]

METHODS AND RESULTS:
The objective of this research was to re-evaluate the antioxidant effects of the prenylated flavonoids from Sophora flavescens via in vitro 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), peroxynitrite (ONOO(-)), and total reactive oxygen species (ROS) assays. In addition, a further examination of kuraridinol, kurarinol, and kurarinone, also isolated from S. flavescens, was carried out by the inhibition of tert-butylhydroperoxide (t-BHP)-induced intracellular ROS generation and t-BHP-induced activation of nuclear factor-kappaB (NF-kappaB). Upon re-examination of the ethyl acetate (EtOAc) soluble fraction of S. flavescens, two major prenylated chalcones, including kuraridin and kuraridinol, along with a minor prenylated flavonol, Kushenol C, were isolated as good DPPH scavengers. This was in contrast to the prenylated flavanones, sophoraflavanone G and kurarinone, which were isolated from the methylene chloride (CH(2)Cl(2)) fraction of the same source. Five flavanones consisting of kushenol E, leachianone G, kurarinol, sophoraflavanone G, and kurarinone exhibited significant antioxidant potentials in the ABTS, ONOO(-), and total ROS assays; however, the prenylated chalcones and prenylated flavonol showed more potent scavenging/inhibitory activities than the prenylated flavanones. Therefore, the prenylated chalcones and prenylated flavonol, rather than the prenylated flavanones, may make important contributions toward the marked antioxidant capacities of S. flavescens. Furthermore, kuraridinol, kurarinol, and kurarinone showed significant inhibitory activities against intracellular ROS levels as well as NF-kappaB activation by t-BHP.
CONCLUSIONS:
Overall, the results indicate that S. flavescens and its prenylated flavonoids may possess good anti-inflammatory activity, which is implicated in their significant antioxidant activity.
Molecules . 2020 Apr 12;25(8):1768.
In vitro Anti-Inflammatory and Anti-Oxidative Stress Activities of Kushenol C Isolated from the Roots of Sophora flavescens[Pubmed: 32290603]
Abstract Kushenol C (KC) is a prenylated flavonoid isolated from the roots of Sophora flavescens aiton. Little is known about its anti-inflammatory and anti-oxidative stress activities. Here, we investigated the anti-inflammatory and anti-oxidative stress effects of KC in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, and tert-butyl hydroperoxide (tBHP)-induced oxidative stress in HaCaT cells. The results demonstrated that KC dose-dependently suppressed the production of inflammatory mediators, including NO, PGE2, IL-6, IL1β, MCP-1, and IFN-β in LPS-stimulated RAW264.7 macrophages. The study demonstrated that the inhibition of STAT1, STAT6, and NF-κB activations by KC might have been responsible for the inhibition of NO, PGE2, IL-6, IL1β, MCP-1, and IFN-β in the LPS-stimulated RAW264.7 macrophages. KC also upregulated the expression of HO-1 and its activities in the LPS-stimulated RAW264.7 macrophages. The upregulation of Nrf2 transcription activities by KC in the LPS-stimulated RAW264.7 macrophages was demonstrated to be responsible for the upregulation of HO-1 expression and its activity in LPS-stimulated RAW264.7 macrophages. In HaCaT cells, KC prevented DNA damage and cell death by upregulating the endogenous antioxidant defense system involving glutathione, superoxide dismutase, and catalase, which prevented reactive oxygen species production from tert-butyl hydroperoxide (tBHP)-induced oxidative stress in HaCaT cells. The upregulated activation of Nrf2 and Akt in the PI3K-Akt signaling pathway by KC was demonstrated to be responsible for the anti-oxidative stress activity of KC in HaCaT cells. Collectively, the study suggests that KC can be further investigated as a potential anti-inflammatory candidate for the treatment of inflammatory diseases. Keywords: Sophora flavescens; anti-inflammation; anti-oxidative stress; Kushenol C.
Kushenol C Description
Source: The roots of Sophora flavescens Ait.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
4'-Hydroxy-5,7,3'-trimethoxyflavon...

Catalog No: CFN95398
CAS No: 1239-68-5
Price: $318/5mg
(1E)-3-methoxy-8,12-epoxygermacra-...

Catalog No: CFN95219
CAS No: 1393342-06-7
Price: $413/5mg
Fortunellin-6''-beta-D-glucopyrano...

Catalog No: CFN95315
CAS No: 1218774-64-1
Price: $318/5mg
Polygalin C

Catalog No: CFN95118
CAS No: 934768-05-5
Price: $288/5mg
Lonicerin

Catalog No: CFN95055
CAS No: 25694-72-8
Price: $168/10mg
Stevioside D

Catalog No: CFN95230
CAS No: 1310055-59-4
Price: $463/5mg
N-Methylcorydalmine

Catalog No: CFN95204
CAS No: 81010-29-9
Price: $398/5mg
(-)-5'-Methoxyisolariciresinol 3al...

Catalog No: CFN95403
CAS No: 143236-03-7
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2805 mL 11.4025 mL 22.805 mL 45.61 mL 57.0125 mL
5 mM 0.4561 mL 2.2805 mL 4.561 mL 9.122 mL 11.4025 mL
10 mM 0.2281 mL 1.1403 mL 2.2805 mL 4.561 mL 5.7013 mL
50 mM 0.0456 mL 0.2281 mL 0.4561 mL 0.9122 mL 1.1403 mL
100 mM 0.0228 mL 0.114 mL 0.2281 mL 0.4561 mL 0.5701 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Am. J. Chinese Med., 2012, 38(2):415-29.
Selective inhibition of prenylated flavonoids from Sophora flavescens against BACE1 and cholinesterases.[Pubmed: 20387235 ]
It was previously reported that certain lavandulylated flavanones from Sophora flavescens are beta-site APP cleaving enzyme 1 (BACE1) inhibitors; however, based upon their levels within the extract, their inhibitory effects should be higher than expected. Moreover, chalcones and flavonols were reported to exert higher bioactivities than flavanones. These findings have led to a further search for other possible constituents potentially contributing to the strong inhibitory activity of the S. flavescens extract.
METHODS AND RESULTS:
In this study, BACE1 activities were significantly inhibited by 8-lavandulylkaempferol (IC(50) 7.29 microM), kuraridinol (IC(50) 7.10 microM), kuraridin (IC(50) 6.03 microM), and Kushenol C (IC(50) 5.45 microM) from the ethyl acetate fraction, along with desmethylanhydroicaritin (IC(50) 1.86 microM), xanthohumol (IC(50) 7.19 microM), and leachianone G (IC(50) 8.56 microM) from the dichloromethane fraction of the extract. The results indicate that the prenyl group, rather than the lavandulyl group, and the flavonols and chalcones, rather than flavanones, might make predominant contributions to BACE1 inhibition. In particular, 8-lavandulylkaempferol exhibited significant inhibitory effects with IC(50) values of 7.10 and 8.11 microM for butyrylcholinesterase and acetylcholinesterase, respectively, when compared to its counterpart, desmethylanhydroicaritin. This indicates that the lavandulyl group might play a predominant role in both cholinesterase inhibitions.
CONCLUSIONS:
This is the first study indicating that prenylated flavonoids exert varying degrees of inhibition primarily through their skeleton (flavonols, chalcones, flavanones), as well as their lipophilic chain length (prenyl and lavandulyl groups). Therefore, S. flavescens and its prenylated flavonoids, possessing low molecular weights and lipophilic moieties may be potent preventive and therapeutic candidates for Alzheimer's disease.
Cucurbitacin B

Catalog No: CFN99129
CAS No: 6199-67-3
Price: $70/20mg
Panaxadiol

Catalog No: CFN99981
CAS No: 19666-76-3
Price: $40/20mg
Kobophenol A

Catalog No: CFN92530
CAS No: 124027-58-3
Price: $318/10mg
Elemicin

Catalog No: CFN90685
CAS No: 487-11-6
Price: $30/20mg
Ginkgolide C

Catalog No: CFN99639
CAS No: 15291-76-6
Price: $30/20mg
Ganoderic acid H

Catalog No: CFN92056
CAS No: 98665-19-1
Price: $318/10mg
Dehydropachymic acid

Catalog No: CFN92742
CAS No: 77012-31-8
Price: $268/10mg
Vomifoliol

Catalog No: CFN98245
CAS No: 23526-45-6
Price: $ /
Demethylzeylasteral

Catalog No: CFN90136
CAS No: 107316-88-1
Price: $40/20mg
Isosilybin

Catalog No: CFN90260
CAS No: 72581-71-6
Price: $138/20mg
Tags: buy Kushenol C | Kushenol C supplier | purchase Kushenol C | Kushenol C cost | Kushenol C manufacturer | order Kushenol C | Kushenol C distributor