Science | Nature | Cell | View More
Natural Products
Kushenol E
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Kushenol E
Price:
CAS No.: 99119-72-9
Catalog No.: CFN92388
Molecular Formula: C25H28O6
Molecular Weight: 424.5 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The roots of Sophora flavescens Ait.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • CSIRO - Agriculture Flagship (Australia)
  • Imperial College London (United Kingdom)
  • Sanford Burnham Prebys Medical ... (USA)
  • The Australian National University (Australia)
  • University of Perugia (Italy)
  • Leibniz-Institut für Pflanzenb... (Germany)
  • Heinrich-Heine-University Düss... (Germany)
  • University of Eastern Finland (Finland)
  • Kyushu University (Japan)
  • Kamphaengphet Rajabhat University (Thailand)
  • University of Sao Paulo (Brazil)
  • More...
Package
Featured Products
Arctigenin 4'-O-beta-gentiobioside

Catalog No: CFN90714
CAS No: 41682-24-0
Price: $268/5mg
Isorhyncophylline

Catalog No: CFN92553
CAS No: 6859-01-4
Price: $158/20mg
Calceolarioside B

Catalog No: CFN90647
CAS No: 105471-98-5
Price: $238/20mg
Oxoglaucine

Catalog No: CFN90508
CAS No: 5574-24-3
Price: $318/5mg
Dehydrotrametenolic acid

Catalog No: CFN90577
CAS No: 29220-16-4
Price: $188/20mg
Procyanidin A2

Catalog No: CFN96491
CAS No: 41743-41-3
Price: $238/10mg
Senkirkine

Catalog No: CFN00424
CAS No: 2318-18-5
Price: $ /
Genkwanin

Catalog No: CFN98670
CAS No: 437-64-9
Price: $60/20mg
Ginsenoside Rd2 (Quinquenoside L10)

Catalog No: CFN95231
CAS No: 83480-64-2
Price: $318/10mg
Bergapten

Catalog No: CFN98766
CAS No: 484-20-8
Price: $40/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Kushenol E exhibits significant antioxidant potentials in the ABTS, ONOO(-), and total ROS assays.
Targets: NF-kB | ROS
In vitro:
Biol Pharm Bull. 2008 May;31(5):908-15.
Re-evaluation of the antioxidant prenylated flavonoids from the roots of Sophora flavescens.[Pubmed: 18451517]
This was in contrast to the prenylated flavanones, sophoraflavanone G and kurarinone, which were isolated from the methylene chloride (CH(2)Cl(2)) fraction of the same source.
METHODS AND RESULTS:
Five flavanones consisting of Kushenol E, leachianone G, kurarinol, sophoraflavanone G, and kurarinone exhibited significant antioxidant potentials in the ABTS, ONOO(-), and total ROS assays; however, the prenylated chalcones and prenylated flavonol showed more potent scavenging/inhibitory activities than the prenylated flavanones. Therefore, the prenylated chalcones and prenylated flavonol, rather than the prenylated flavanones, may make important contributions toward the marked antioxidant capacities of S. flavescens. Furthermore, kuraridinol, kurarinol, and kurarinone showed significant inhibitory activities against intracellular ROS levels as well as NF-kappaB activation by t-BHP.
CONCLUSIONS:
Overall, the results indicate that S. flavescens and its prenylated flavonoids may possess good anti-inflammatory activity, which is implicated in their significant antioxidant activity.
Kushenol E Description
Source: The roots of Sophora flavescens Ait.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Hydroxytyrosol 1-O-glucoside

Catalog No: CFN95367
CAS No: 76873-99-9
Price: $318/10mg
Umbelliferone 7-O-rutinoside

Catalog No: CFN95431
CAS No: 135064-04-9
Price: $318/10mg
Hosenkoside D

Catalog No: CFN95521
CAS No: 156823-94-8
Price: $318/5mg
New compound 23

Catalog No: CFN95587
CAS No: N/A
Price: $318/5mg
Safflospermidine B

Catalog No: CFN95254
CAS No: N/A
Price: $413/5mg
Ephedrannin D1

Catalog No: CFN95547
CAS No: 1592431-55-4
Price: $318/5mg
Mahuannin B

Catalog No: CFN95554
CAS No: 82796-37-0
Price: $318/5mg
8'-O-(3-hydroxy-3-methylglutaryl)-...

Catalog No: CFN95308
CAS No: 69790-31-4
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3557 mL 11.7786 mL 23.5571 mL 47.1143 mL 58.8928 mL
5 mM 0.4711 mL 2.3557 mL 4.7114 mL 9.4229 mL 11.7786 mL
10 mM 0.2356 mL 1.1779 mL 2.3557 mL 4.7114 mL 5.8893 mL
50 mM 0.0471 mL 0.2356 mL 0.4711 mL 0.9423 mL 1.1779 mL
100 mM 0.0236 mL 0.1178 mL 0.2356 mL 0.4711 mL 0.5889 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
World Journal of Pharmaceutical Research, 2016 , 5990 (2) :274-83.
IN SILICO PASS PREDICTION AND MOLECULAR DOCKING OF ISOLATED COMPOUNDS FROM FLEMINGIA MACROPHYLLA FOR THROMBOLYTIC EFFECT[Reference: WebLink]

METHODS AND RESULTS:
A wide range of docking score found during molecular docking by CPI server. Beta-sitosterol, cajanin, flemichin E, flemiflavanone A, genistein, genistin, Kushenol E, neoraufurane and prunetin showed the docking score -7.9, -8.4, -8.8, -8.6, -8.0, -8.6, -8.7, -8.3 and -7.9, respectively.
CONCLUSIONS:
Data from the both in silico models showed similar values for the same compound, because flemichin E showed high value and beta-sitosterol, prunetin showed low value in both in silico models.
Arctigenin 4'-O-beta-gentiobioside

Catalog No: CFN90714
CAS No: 41682-24-0
Price: $268/5mg
Isorhyncophylline

Catalog No: CFN92553
CAS No: 6859-01-4
Price: $158/20mg
Calceolarioside B

Catalog No: CFN90647
CAS No: 105471-98-5
Price: $238/20mg
Oxoglaucine

Catalog No: CFN90508
CAS No: 5574-24-3
Price: $318/5mg
Dehydrotrametenolic acid

Catalog No: CFN90577
CAS No: 29220-16-4
Price: $188/20mg
Procyanidin A2

Catalog No: CFN96491
CAS No: 41743-41-3
Price: $238/10mg
Senkirkine

Catalog No: CFN00424
CAS No: 2318-18-5
Price: $ /
Genkwanin

Catalog No: CFN98670
CAS No: 437-64-9
Price: $60/20mg
Ginsenoside Rd2 (Quinquenoside L10)

Catalog No: CFN95231
CAS No: 83480-64-2
Price: $318/10mg
Bergapten

Catalog No: CFN98766
CAS No: 484-20-8
Price: $40/20mg
Tags: buy Kushenol E | Kushenol E supplier | purchase Kushenol E | Kushenol E cost | Kushenol E manufacturer | order Kushenol E | Kushenol E distributor