(-)-Lariciresinol | CAS:83327-19-9 | Manufacturer ChemFaces

(-)-Lariciresinol

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Description:

Lariciresinol administration can inhibit the tumor growth and tumor angiogenesis, conceivable importance of dietary lignan lariciresinol in inhibition of breast cancer development.

Targets:

VEGFR

In vivo:

Int J Cancer. 2008 Sep 1;123(5):1196-204.

Dietary lariciresinol attenuates mammary tumor growth and reduces blood vessel density in human MCF-7 breast cancer xenografts and carcinogen-induced mammary tumors in rats.[Pubmed: 18528864 ]

Lariciresinol is a dietary lignan that accounts for a significant portion of the total phytoestrogen intake from Western foods. Recent epidemiological studies suggest that high dietary intake of lignans and lariciresinol is associated with reduced breast cancer risk. However, no causal relationship between lariciresinol intake and breast cancer development has been established.
METHODS AND RESULTS:
In this study, we investigated for the first time the effects and possible mechanisms of action of lariciresinol on hormone responsive mammary cancer in vivo in dimethylbenz[a]anthracene induced mammary cancer in rats, and in human MCF-7 breast cancer xenografts in athymic mice. For tumor bearing rats, lariciresinol (3 or 15 mg/kg of body weight) or vehicle was administered p.o. daily for 9 weeks. For E2-maintained ovariectomized athymic mice bearing orthotopic MCF-7 tumors, control diet (AIN-93G) or lariciresinol containing diet (AIN-93G supplemented with 20 or 100 mg of lariciresinol/kg of diet) was administered for 5 weeks. In both models, lariciresinol administration inhibited the tumor growth and tumor angiogenesis. In MCF-7 cells, enterolactone significantly inhibited the E2-stimulated VEGF secretion. Moreover, in MCF-7 xenografts, lariciresinol administration enhanced tumor cell apoptosis and increased estrogen receptor beta expression. Lariciresinol and its further metabolites secoisolariciresinol, enterodiol and enterolactone were found in serum of both rats and athymic mice confirming a similar lignan metabolism pattern as in humans.
CONCLUSIONS:
These findings indicate conceivable importance of dietary lignan lariciresinol in inhibition of breast cancer development.

(-)-Lariciresinol Description

Source:	The roots of Syringa oblata Lindl.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

FEBS Lett. 2007 Feb 20;581(4):603-10.

(+)-Pinoresinol/(-)-lariciresinol reductase from Linum perenne Himmelszelt involved in the biosynthesis of justicidin B.[Pubmed: 17257599]

METHODS AND RESULTS:
A cDNA encoding a pinoresinol-lariciresinol reductase PLR (PLR-Lp1) was isolated from a cell culture of Linum perenne Himmelszelt accumulating the arylnaphthalene lignan justicidin B. The recombinant PLR-Lp1 prefers (+)-pinoresinol in the first reaction step, but (-)-Lariciresinol in the second step.
CONCLUSIONS:
Therefore, it is the first PLR described with opposite enantiospecificity within the two reaction steps catalysed by PLRs. Hairy root lines transformed with an ihpRNAi construct to suppress plr gene expression show less mRNA accumulation for the plr-Lp1 gene and PLR enzyme activity. Justicidin B accumulation was reduced down to 24% in comparison to control lines showing the involvement of PLR-Lp1 in the biosynthesis of justicidin B.

Product Name	(-)-Lariciresinol
Price:
CAS No.:	83327-19-9
Catalog No.:	CFN92501
Molecular Formula:	C₂₀H₂₄O₆
Molecular Weight:	360.4 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The roots of Syringa oblata Lindl.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Antiangiogenic Compound Library Lignans Compound Library VEGFR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7747 mL	13.8735 mL	27.7469 mL	55.4939 mL	69.3674 mL
5 mM	0.5549 mL	2.7747 mL	5.5494 mL	11.0988 mL	13.8735 mL
10 mM	0.2775 mL	1.3873 mL	2.7747 mL	5.5494 mL	6.9367 mL
50 mM	0.0555 mL	0.2775 mL	0.5549 mL	1.1099 mL	1.3873 mL
100 mM	0.0277 mL	0.1387 mL	0.2775 mL	0.5549 mL	0.6937 mL

CFN95283	(+)-Lariciresinol 4'-O-beta-D-Glucopyranosyl-(1->3)-beta-D-glucopyranoside	639857-95-7	684.7	C₃₂H₄₄O₁₆
CFN98365	Olivil	2955-23-9	376.4	C₂₀H₂₄O₇
CFN89274	Olivil 4'-O-glucoside	76880-93-8	538.54	C₂₆H₃₄O₁₂
CFN97541	Massoniresinol	96087-10-4	392.4	C₂₀H₂₄O₈
CFN97860	Olivil monoacetate	1016974-78-9	418.44	C₂₂H₂₆O₈
CFN95027	Fargesol	128855-64-1	404.5	C₂₂H₂₈O₇
CFN95031	9-O-Acetyl-fargesol	449172-61-6	446.5	C₂₄H₃₀O₈
CFN96706	5'-Methoxylariciresinol	105256-12-0	390.43	C₂₁H₂₆O₇
CFN92502	Justiciresinol	136051-41-7	390.4	C₂₁H₂₆O₇
CFN89318	Ciwujiatone	218901-26-9	434.44	C₂₂H₂₆O₉