Lauterine | CAS:28200-65-9 | Manufacturer ChemFaces

Lauterine

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Lauterine is a DNA topoisomerase inhibitor.

Targets:

Topoisomerase

In vitro:

J Nat Prod. 1994 Jan;57(1):68-73.

Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea.[Pubmed: 8158166]

METHODS AND RESULTS:
The oxoaporphine alkaloids oxophoebine [1] and liriodenine [2] have been isolated from Xylopia aethiopica (Annonaceae). Both showed selective toxicity against DNA repair and recombination deficient mutants of the yeast Saccharomyces cerevisae. Three related but inactive compounds, oxoglaucine [3], O-methylmoschatoline [4], and lysicamine [5], were also isolated from this plant. Selective toxicity was also observed for 10-methoxyliriodenine (Lauterine) [6] and 10-hydroxyliriodenine [7], two oxoaporphine alkaloids isolated from Miliusa cf. banacea (Annonaceae). The structure of 10-hydroxyliriodenine [7], a novel oxoaporphine, was determined by spectroscopic methods and chemical conversion to compound 6.
CONCLUSIONS:
The role of the bioactive oxoaporphine alkaloids as DNA topoisomerase inhibitors is discussed.

Lauterine Description

Source:	The plants of Guatteria elata R. E. Fries.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Lauterine
Price:
CAS No.:	28200-65-9
Catalog No.:	CFN96757
Molecular Formula:	C₁₈H₁₁NO₄
Molecular Weight:	305.28 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The plants of Guatteria elata R. E. Fries.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Alkaloids Compound Library Topoisomerase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.2757 mL	16.3784 mL	32.7568 mL	65.5136 mL	81.892 mL
5 mM	0.6551 mL	3.2757 mL	6.5514 mL	13.1027 mL	16.3784 mL
10 mM	0.3276 mL	1.6378 mL	3.2757 mL	6.5514 mL	8.1892 mL
50 mM	0.0655 mL	0.3276 mL	0.6551 mL	1.3103 mL	1.6378 mL
100 mM	0.0328 mL	0.1638 mL	0.3276 mL	0.6551 mL	0.8189 mL

CFN89548	1,2,3,10-Tetramethoxy-9-(2-hydroxy-4,5-dimethoxybenzyloxy)oxoaporphine	872729-33-4	533.52	C₂₉H₂₇NO₉
CFN98975	Norcepharadione B	57576-41-7	307.3	C₁₈H₁₃NO₄
CFN91874	Aristoliukine B	217310-32-2	309.27	C₁₇H₁₁NO₅
CFN94151	Cepharadione B	55610-02-1	321.33	C₁₉H₁₅NO₄
CFN96041	Cepharadione A	55610-01-0	305.3	C₁₈H₁₁NO₄
CFN91018	(-)-Anonaine	1862-41-5	265.31	C₁₇H₁₅NO₂
CFN91019	Roemerine	548-08-3	279.33	C₁₈H₁₇NO₂
CFN91767	Fissistigine A	70420-58-5	311.33	C₁₈H₁₇NO₄
CFN93031	Laetanine	72361-67-2	313.35	C₁₈H₁₉NO₄
CFN90492	Laurolitsine	5890-18-6	313.34	C₁₈H₁₉NO₄