Leptomerine | CAS:22048-97-1 | Manufacturer ChemFaces

Leptomerine

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Size /Price /Stock	10 mM * 1 mL in DMSO / $71.9 / In-stock
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Description:

Leptomerine (IC₅₀ = 2.5 mM) shows potent anticholinesterasic activity.

Targets:

AChR

In vitro:

Molecules. 2010 Dec 13;15(12):9205-13.

Alkaloids from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer disease.[Pubmed: 21160449]

Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guarantã, goiabeira, is a native tree from Brazil.
METHODS AND RESULTS:
Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, Leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid Leptomerine showed the highest activity (IC₅₀ = 2.5 mM), similar to that of the reference compound galanthamine (IC₅₀ = 1.7 mM).
CONCLUSIONS:
The results showed for the first time the presence of alkaloids Leptomerine and skimmianine in E. leiocarpa (Engl.) with potent anticholinesterasic activity.

Leptomerine Description

Source:	The herbs of Haplophyllum leptomerum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Leptomerine
Price:	$208 / 10mg
CAS No.:	22048-97-1
Catalog No.:	CFN90841
Molecular Formula:	C₁₃H₁₅NO
Molecular Weight:	201.3 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Haplophyllum leptomerum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticholinesterase Compound Library Alkaloids Compound Library AChR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.9677 mL	24.8385 mL	49.6771 mL	99.3542 mL	124.1927 mL
5 mM	0.9935 mL	4.9677 mL	9.9354 mL	19.8708 mL	24.8385 mL
10 mM	0.4968 mL	2.4839 mL	4.9677 mL	9.9354 mL	12.4193 mL
50 mM	0.0994 mL	0.4968 mL	0.9935 mL	1.9871 mL	2.4839 mL
100 mM	0.0497 mL	0.2484 mL	0.4968 mL	0.9935 mL	1.2419 mL

CFN98213	Antidesmone	222629-77-8	319.4	C₁₉H₂₉NO₃
CFN89240	1-Hydroxyacridone	65582-54-9	211.22	C₁₃H₉NO₂
CFN96973	1,7-Dihydroxyacridone	112649-95-3	227.21	C₁₃H₉NO₃
CFN89268	1-Hydroxy-N-methylacridone	16584-54-6	225.24	C₁₄H₁₁NO₂
CFN99297	1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one	1189362-86-4	271.3	C₁₅H₁₃NO₄
CFN89147	Arborinine	5489-57-6	285.29	C₁₆H₁₅NO₄
CFN89259	Rutacridone	17948-33-3	307.34	C₁₉H₁₇NO₃
CFN99672	Sambutoxin	160047-56-3	453.6	C₂₈H₃₉NO₄
CFN98094	1-Methyl-2-pentyl-4(1H)-quinolinone	22048-98-2	229.3	C₁₅H₁₉NO
CFN97283	Schinifoline	80554-58-1	257.4	C₁₇H₂₃NO