(-)-Licarin B | CAS:51020-87-2 | Manufacturer ChemFaces

(-)-Licarin B

ChemFaces products have been cited in many studies from excellent and top scientific journals

Product Name	(-)-Licarin B
Price:	$318 / 3mg
CAS No.:	51020-87-2
Catalog No.:	CFN99751
Molecular Formula:	C₂₀H₂₀O₄
Molecular Weight:	324.37 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	White powder
Source:	The seeds of Myristica fragrans Houtt.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $270.3 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Licarin B can improve insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway in 3T3-L1 adipocytes, it as a promising bioactive for insulin resistance and associated complications through its partial PPARγ activity.

Targets:

PPAR | GLUT | PI3K | Akt | IRS-1

In vitro:

Rsc Adv., 2016, 6(83):79859-70.

Licarin B from Myristica fragrans improves insulin sensitivity via PPARγ and activation of GLUT4 in IRS-1/PI3K/AKT pathway in 3T3- L1 adipocytes[Reference: WebLink]

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors regulating lipid and glucose metabolism.
METHODS AND RESULTS:
The objective of the present study is to characterize the cellular effect of Licarin B (LB), a neolignan isolated from Myristica fragrans on the PPARγ and insulin signaling pathways in 3T3-L1 preadipocytes. The molecular mechanism of action of LB on PPARγ and insulin signaling pathways were studied using in vitro and in silico methods. Functional activation of PPARγ in vitro was confirmed by 3T3-L1 preadipocyte differentiation, regulation of target genes and protein expression. LB caused triglyceride accumulation during adipogenesis but significantly less compared to rosiglitazone (RG), a PPARγ full agonist. In in vitro time-resolved fluorescence resonance energy transfer-based competitive binding assay, LB showed an IC50 value of 2.4 μM whereas for RG and GW9662 it was 57.96 nM and 18.68 nM respectively. Virtual screening of LB with PPARγ showed hydrophobic interactions with a binding energy of -9.36 kcal mol⁻1. Interestingly enough LB improved insulin sensitivity by up regulating the GLUT4 expression and translocation via IRS-1/PI3K/AKT pathway, enhanced adiponectin secretion and modulated mRNA expression profile of PPARγ target genes C/EBPα, IRS-2, and LPL significantly compared to RG.
CONCLUSIONS:
This scientifically validate LB as a promising bioactive for insulin resistance and associated complications through its partial PPARγ activity.

(-)-Licarin B Description

Source:	The seeds of Myristica fragrans Houtt.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Insulin-stimulated action Compound Library Anti-diabetic complications Compound Library Anti-insulin resistance Compound Library Lignans Compound Library PPAR Inhibitor Library PI3K Inhibitor Library GLUT Inhibitor Library Akt Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0829 mL	15.4145 mL	30.829 mL	61.658 mL	77.0725 mL
5 mM	0.6166 mL	3.0829 mL	6.1658 mL	12.3316 mL	15.4145 mL
10 mM	0.3083 mL	1.5414 mL	3.0829 mL	6.1658 mL	7.7072 mL
50 mM	0.0617 mL	0.3083 mL	0.6166 mL	1.2332 mL	1.5414 mL
100 mM	0.0308 mL	0.1541 mL	0.3083 mL	0.6166 mL	0.7707 mL

CFN99751	(-)-Licarin B	51020-87-2	324.37	C₂₀H₂₀O₄
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CFN99373	Icariside E5	126176-79-2	522.6	C₂₆H₃₄O₁₁
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CFN97599	Denudatin B	87402-88-8	356.42	C₂₁H₂₄O₅
CFN98208	Conocarpan	221666-27-9	266.3	C₁₈H₁₈O₂
CFN89302	Conocarpan acetate	56319-04-1	308.37	C₂₀H₂₀O₃
CFN98244	Licarin A	23518-30-1	326.4	C₂₀H₂₂O₄
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