alpha-Carotene | CAS:7488-99-5 | Manufacturer ChemFaces

alpha-Carotene

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Mulberrin

Catalog No: CFN97085
CAS No: 62949-79-5
Price: $288/20mg

D-(+)-Glucose

Catalog No: CFN99769
CAS No: 50-99-7
Price: $30/20mg

Lutein

Catalog No: CFN99384
CAS No: 127-40-2
Price: $80/20mg

Senkirkine

Catalog No: CFN00424
CAS No: 2318-18-5
Price: $ /

Cucurbitacin A

Catalog No: CFN90324
CAS No: 6040-19-3
Price: $ /

Caffeoyl alcohol

Catalog No: CFN70348
CAS No: 3598-26-3
Price: $318/10mg

Procyanidin B1

Catalog No: CFN99557
CAS No: 20315-25-7
Price: $238/20mg

Ganoderic acid TR

Catalog No: CFN92235
CAS No: 862893-75-2
Price: $368/5mg

Cannabidivarin

Catalog No: CFN89253
CAS No: 24274-48-4
Price: $ / mg

Alantolactone

Catalog No: CFN99934
CAS No: 546-43-0
Price: $30/20mg

Description:

alpha-Carotene has anti-metastasis activity, it inhibits metastasis in Lewis lung carcinoma in vitro, and suppresses lung metastasis and tumor growth in combination with taxol in tumor xenografted C57BL/6 mice. alpha-Carotene has inhibitory effects on proliferation of the human neuroblastoma cell line GOTO.

Targets:

FAK | MMP(e.g.TIMP) | MAPK

In vitro:

J Nutr Biochem. 2015 Jun;26(6):607-15.

Alpha-carotene inhibits metastasis in Lewis lung carcinoma in vitro, and suppresses lung metastasis and tumor growth in combination with taxol in tumor xenografted C57BL/6 mice.[Pubmed: 25736483 ]

This study aimed to investigate the anti-metastatic activity of alpha-Carotene (AC) in Lewis lung carcinoma (LLC) and in combination with taxol in LLC-xenografted C57BL/6 mice.
METHODS AND RESULTS:
Cell culture studies reveal that AC significantly inhibited invasion, migration and activities of matrix metalloproteinase (MMP)-2, -9 and urokinase plasminogen activator but increased protein expression of tissue inhibitor of MMP (TIMP)-1, -2 and plasminogen activator inhibitor (PAI)-1. These effects of AC are similar to those of β-carotene at the same concentration (2.5 μM). AC (2.5 μM) also significantly inhibited integrin β1-mediated phosphorylation of focal adhesion kinase (FAK) which then decreased the phosphorylation of MAPK family. Findings from the animal model reveal that AC treatment (5m g/kg) alone significantly decreased lung metastasis without affecting primary tumor growth, whereas taxol treatment (6 mg/kg) alone exhibited significant inhibition on both actions, as compared to tumor control group. AC treatment alone significantly decreased protein expression of integrin β1 but increased protein expression of TIMP-1 and PAI-1 without affecting protein expression of TIMP-2 and phosphorylation of FAK in lung tissues, whereas taxol treatment alone significantly increased protein expression of TIMP-1, PAI-1 and TIMP-2 but decreased protein expression of integrin β1 and phosphorylation of FAK. The combined treatment produced stronger actions on lung metastasis and lung tissues protein expression of TIMP-1, TIMP-2 and PAI-1.
CONCLUSIONS:
Overall, we demonstrate that AC effectively inhibits LLC metastasis and suppresses lung metastasis in combination with taxol in LLC-bearing mice, suggesting that AC could be used as an anti-metastatic agent or as an adjuvant for anti-cancer drugs.

J Natl Cancer Inst. 1989 Nov 1;81(21):1649-52.

Inhibitory effects of alpha-carotene on proliferation of the human neuroblastoma cell line GOTO.[Pubmed: 2795693]

METHODS AND RESULTS:
alpha-Carotene inhibited the proliferation of the human neuroblastoma cell line GOTO in a dose- and time-dependent manner. In addition, it was about 10 times more inhibitory than beta-carotene. Northern blot analysis indicated that alpha-Carotene caused maximum suppression of the level of the N-myc messenger RNA of GOTO cells. This suppression occurred within 18 hours of alpha-Carotene treatment, after which the level of the N-myc messenger RNA gradually recovered to the basal level. Analysis by flow cytometry indicated that when GOTO cells were exposed to alpha-Carotene, they were arrested in the G0-G1 phase of their cell cycle. However, as the level of the N-myc messenger RNA was recovering, these cells resumed normal cycling.
CONCLUSIONS:
These results indicate that the reduction in the level of the N-myc messenger RNA caused by alpha-Carotene is closely linked with G0-G1 arrest.

In vivo:

J Nutr Biochem . 2015 Jun;26(6):607-15.

Alpha-carotene inhibits metastasis in Lewis lung carcinoma in vitro, and suppresses lung metastasis and tumor growth in combination with taxol in tumor xenografted C57BL/6 mice[Pubmed: 25736483]

Abstract This study aimed to investigate the anti-metastatic activity of α-carotene (AC) in Lewis lung carcinoma (LLC) and in combination with taxol in LLC-xenografted C57BL/6 mice. Cell culture studies reveal that AC significantly inhibited invasion, migration and activities of matrix metalloproteinase (MMP)-2, -9 and urokinase plasminogen activator but increased protein expression of tissue inhibitor of MMP (TIMP)-1, -2 and plasminogen activator inhibitor (PAI)-1. These effects of AC are similar to those of β-carotene at the same concentration (2.5 μM). AC (2.5 μM) also significantly inhibited integrin β1-mediated phosphorylation of focal adhesion kinase (FAK) which then decreased the phosphorylation of MAPK family. Findings from the animal model reveal that AC treatment (5m g/kg) alone significantly decreased lung metastasis without affecting primary tumor growth, whereas taxol treatment (6 mg/kg) alone exhibited significant inhibition on both actions, as compared to tumor control group. AC treatment alone significantly decreased protein expression of integrin β1 but increased protein expression of TIMP-1 and PAI-1 without affecting protein expression of TIMP-2 and phosphorylation of FAK in lung tissues, whereas taxol treatment alone significantly increased protein expression of TIMP-1, PAI-1 and TIMP-2 but decreased protein expression of integrin β1 and phosphorylation of FAK. The combined treatment produced stronger actions on lung metastasis and lung tissues protein expression of TIMP-1, TIMP-2 and PAI-1. Overall, we demonstrate that AC effectively inhibits LLC metastasis and suppresses lung metastasis in combination with taxol in LLC-bearing mice, suggesting that AC could be used as an anti-metastatic agent or as an adjuvant for anti-cancer drugs. Keywords: Lewis lung carcinoma; Metastasis; Taxol; α-Carotene; β-Carotene.

alpha-Carotene Description

Source:	The roots of Daucus carota
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Cancer Res. 1992 Dec 1;52(23):6583-7.

Potent preventive action of alpha-carotene against carcinogenesis: spontaneous liver carcinogenesis and promoting stage of lung and skin carcinogenesis in mice are suppressed more effectively by alpha-carotene than by beta-carotene.[Pubmed: 1423303]

Although beta-carotene has been considered to be a key cancer preventive agent in green and yellow vegetables, other types of carotenoids, such as alpha-Carotene, may also contribute to anticarcinogenic action, since these carotenoids usually coexist with beta-carotene and are detectable in human blood and tissues.
METHODS AND RESULTS:
In this study, we compared the inhibitory effect of natural alpha-Carotene, obtained from palm oil, with that of beta-carotene on spontaneous liver carcinogenesis in C3H/He male mice. The mean number of hepatomas per mouse was significantly decreased by alpha-Carotene supplementation (per os administration in drinking water at a concentration of 0.05%, ad libitum) as compared with that in the control group (P < 0.001, Student's t test). On the other hand, beta-carotene, at the same dose as alpha-Carotene, did not show any such significant difference from the control group. Furthermore, we also compared the antitumor-promoting activity of alpha-Carotene with that of beta-carotene against two-stage mouse lung carcinogenesis (initiator, 4-nitroquinoline 1-oxide; promoter, glycerol). alpha-Carotene, but not beta-carotene, reduced the number of lung tumors per mouse to about 30% of that in the control group (P < 0.001, Student's t test). The higher potency of the antitumor-promoting action of alpha-Carotene compared to beta-carotene was confirmed in other experimental systems; e.g., alpha-Carotene was also found to have a stronger effect than beta-carotene in suppressing the promoting activity of 12-O-tetradecanoylphorbol-13-acetate on skin carcinogenesis in 7,12-dimethylbenz[a]anthracene-initiated mice.
CONCLUSIONS:
These results suggest that not only beta-carotene, but also other types of carotenoids, such as alpha-Carotene, may play an important role in cancer prevention.

Product Name	alpha-Carotene
Price:
CAS No.:	7488-99-5
Catalog No.:	CFN93610
Molecular Formula:	C₄₀H₅₆
Molecular Weight:	536.87 g/mol
Purity:	>=98%
Type of Compound:	Miscellaneous
Physical Desc.:	Powder
Source:	The roots of Daucus carota
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-proliferation Compound Library Anti-metastatic Compound Library Anti-tumor promoting activity Compound Library Miscellaneous Compound Library MMP(e.g.TIMP) Inhibitor Library MAPK Inhibitor Library FAK Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8626 mL	9.3132 mL	18.6265 mL	37.253 mL	46.5662 mL
5 mM	0.3725 mL	1.8626 mL	3.7253 mL	7.4506 mL	9.3132 mL
10 mM	0.1863 mL	0.9313 mL	1.8626 mL	3.7253 mL	4.6566 mL
50 mM	0.0373 mL	0.1863 mL	0.3725 mL	0.7451 mL	0.9313 mL
100 mM	0.0186 mL	0.0931 mL	0.1863 mL	0.3725 mL	0.4657 mL

CFN70370	beta-Cryptoxanthin	472-70-8	552.9	C₄₀H₅₆O
CFN70366	Capsanthin	465-42-9	584.9	C₄₀H₅₆O₃
CFN90096	Astaxanthin	472-61-7	596.85	C₄₀H₅₂O₄
CFN99384	Lutein	127-40-2	568.9	C₄₀H₅₆O₂
CFN70406	Helenien	547-17-1	1045.7	C₇₂H₁₁₆O₄
CFN90234	Zeaxanthin	144-68-3	568.88	C₄₀H₅₆O₂
CFN70273	Physalien	144-67-2	1045.7	C₇₂H₁₁₆O₄
CFN93610	alpha-Carotene	7488-99-5	536.87	C₄₀H₅₆
CFN98117	Beta-Carotene	7235-40-7	536.88	C₄₀H₅₆
CFN90852	Fucoxanthin	3351-86-8	658.9	C₄₂H₅₈O₆